T**7
发帖数: 264 | 1 "Treatment response in Kawasaki disease correlates with sialylation levels
of endogenous but not therapeutic intravenous immunoglobulin G"
背静：
川崎氏病的病因依旧未明，但许多科学家怀疑这可能是一种特殊的病毒感染导致。目前
倾向于把它当成是一种与免疫系统有关的疾病。
是属于幼儿期的一种急性疾病。此病是由日本小儿科医师川崎富作于西元1967年首先提
出报告，故名之为川崎氏病。来自维基百科。
IVIG就不用介绍了吧，搞免疫，血液的人都很熟悉，属于强大治疗效果的蛋白质药物，
尤其是多种自身免疫病，作用机理似乎还不是很清楚。
这篇文章的新颖之处在于探索了治疗性静注球蛋白和内源性球蛋白对于治疗效果的影响。
尤其是针对治疗产生“抵抗”的病人，为什么静注球蛋白没有治疗效果。
文章的主要方法是RT-PCR, ELISA
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1，你的名字
2，你的email
3，你的2－3篇文章的题目 |
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B***v
发帖数: 113 | 2 在一教科书上找到
“In addition to glycosylation of the two canonical Asn297 residues in the
Fc region, N-linked glycans are present in some 20 % of the Fab regions in
human IgG. These glycans include bi-antennary structures that are hyper-
galactosylated, ucosylated, and extensively sialylated.” |
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S*******e
发帖数: 17 | 3 Methods Mol Biol. 2015;1295:275-92. doi: 10.1007/978-1-4939-2550-6_21.
Comprehensive protocol to simultaneously study protein phosphorylation,
acetylation, and N-linked sialylated glycosylation.
Melo-Braga MN1, Ibáñez-Vea M, Larsen MR, Kulej K.
Thanks in advance! |
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b*******g
发帖数: 1309 | 4 Carbohydrate-based vaccines are widely used to prevent infectious diseases,
but their use to fight cancer has so far proved problematic. To increase the
chance of success, researchers are pursuing a number of avenues that have a
common goal: enhance carbohydrates’ ability to induce the human immune
system to mount an effective fight against cancer.
Carbohydrates are studded all over the surfaces of human cells, where they
help with essential functions ranging from protein transport and cell-cell... 阅读全帖 |
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