m****g
发帖数: 530 | 1 德国默克公司已开始进行其在研疫苗Stimuvax的后期临床实验，该疫苗由默克和美国
Oncothyreon制药公司共同研发，
用于治疗不宜进行手术的晚期乳腺癌患者。
这项Ⅲ期临床名为STRIDE，将检测疫苗用于那些采用过激素疗法的患者之后是否能
延长其病情无恶化生存期。此次将招
募900名晚期乳腺癌患者参加实验，实验点数量达180个，遍及30多个国家。
实验相关人员表示，晚期乳腺癌有极大的破坏性，治疗起来难度很大，因此对新型
药物的需求较为迫切。若Stimuvax疫
苗在STRIDE实验中表现良好，这对荷尔蒙受体呈阳性的转移性乳腺癌患者来说无疑是个
好消息。
目前，研究人员也正在通过另一项III期临床检测Stimuvax用于治疗非小细胞肺癌
的疗效。这种疫苗可以激活人体免疫系
统，使之确定并靶向作用于表达MUC1的癌细胞，而MUC1则是一种通常在乳腺癌、非小细
胞肺癌、多发性骨髓瘤、结肠
癌、前列腺癌和卵巢癌患者身上出现的抗原。 |
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m****g
发帖数: 530 | 2 SEATTLE, March 23 /PRNewswire-FirstCall/ -- Oncothyreon Inc. (NASDAQ:ONTY)
today announced that
Merck Serono, a division of Merck KGaA of Darmstadt, Germany, and its U.S.
affiliate, EMD Serono, Inc.,
have temporarily suspended the worldwide clinical development program for
Stimuvax(R) (BLP25 liposomal
vaccine). The suspension is the result of a suspected unexpected serious
adverse reaction in a patient with
multiple myeloma participating in an exploratory clinical trial. This
decision was taken |
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S*P
发帖数: 7575 | 3 Stimuvax, which Merck licensed from U.S. biotech firm Oncothyreon, failed to
increase overall survival in the Phase III clinical trial, the German
chemicals and pharmaceuticals group said on Wednesday.
The trial's coordinating investigator, Frances Shepherd of the University of
Toronto, said the result was disappointing, although she said "notable
treatment effects were observed in certain subgroups of patients".
While this could mean that Merck might conduct more studies to try and find
particu... 阅读全帖 |
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h****6
发帖数: 229 | 4 My comments: Vaccine is more of a maintenance therapy, try it if can to
have a better outcome. It won't any harm.
More quote:
I do realize that I'm not the smartest kid on the block when it comes to
fighting lung cancer but I am the only American, in fact the only English
speaking person to ever take CemaVax so I thought it important to share my
experience. With only a 15% survival rate from the use of chemical treatment
these new developments are very important.
The only reason I searched out ... 阅读全帖 |
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g****e
发帖数: 1426 | 5 Nsclc stands for non-small cell lung cancer, the potential market is huge.
Onty is also in my watch list, Stimuvax p3 result due early next year too. |
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h****6
发帖数: 229 | 6 You may take a look at another vaccine in clinical trial called Stimuvax.
Based on current situation, it was predicted to have 90% of chance of
success. I think there is 95% chance. And it appears to be remarkably
effective for stage IIIB. Not effective for more advanced patients
There is a trial in Asia called "Inspire" probably in Hong kong and
Singapore. Don't know if it is in China. In Japan, it is in phase I. If she
can get in, it is of course free. 1/3 of patients are on placebo. You can
t... 阅读全帖 |
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m******h
发帖数: 32 | 7 非常感谢，我看到了这个stimuvax在中国招人试药，我要我叔叔联系一下看。
就是怕万一抽到安慰剂的话，希望能够通过炎症反应判断出来。
看您的意思是说对晚期的癌症患者估计够呛有效是吧？
she |
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n****e
发帖数: 4990 | 8 I guess here is the reason it jumps, but it is over
Oncothyreon Inc (ONTY) plunged 6.17 percent to $3.65 in the pre-market
trading. Merck Serono, a division of Merck KGaA of Darmstadt, Germany,
informed Oncothyreon on Dec. 22 that the Independent Data Monitoring
Committee (DMC) for the Phase 3 START trial of Stimuvax in non-small cell
lung cancer met and the DMC recommendation is to continue the study.
in |
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d******8
发帖数: 1972 | 9 http://www.thestreet.com/story/11351242/1/10-biotech-stock-pred
BOSTON (TheStreet) -- Ten biotech predictions for 2012:
1. The Amgen(AMGN_) strategy of returning cash to shareholders in form of
share buybacks, Dutch tender offers and dividends is abandoned in favor of
ramped up acquisitions i.e. Gilead Sciences(GILD_) buying Pharmasset(VRUS_).
Large-cap biotech firms start acting like Big Pharma -- choosing to buy
growth instead of seeking it from internal drug development.
2. After much wrangli... 阅读全帖 |
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D******9
发帖数: 2665 | 10 Stimuvax data would not be released until early 2013.
要是不急，等到下半年肯定有一波。我打算开始买入了， 呵呵。 这个体内的免疫治疗
应该比DNDN强多了， 要是最后证明有效果的话。 |
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