n****r 发帖数: 246 | 1 Karel Svoboda在Winfried Denk那里做的博士后,物理出生,在neural circuits领域也
算个牛人吧。
以下转自他实验室主页:
Karel Svoboda is a Group Leader at HHMI's Janelia Farm Research Campus. His
lab is working on the structure, function and plasticity of neocortical circ
uits, mostly in the context of somatosensation. He is also interested in the
development of optical, physiological and molecular methods for neuroscienc
e. Svoboda received a BA in physics from Cornell University and a PhD in Bio
physics from Harvard University. For h... 阅读全帖 |
|
m**e 发帖数: 857 | 2 恩,he is a neuroscience editor for Nature and co-curator of several groups
at Nature Network.
University of Notre Dame
B.S., B.A.
Double-major in biology and Art History
Mayo Clinic and Graduate School
Ph.D.
Molecular Neuroscience emphasis in the laboratory of Mark McNiven.
Postdoctoral Fellow
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
03/04 to 09/06
Conducted circuit and plasticity research in the laboratory of Karel Svoboda.
Postdoctoral Fellow
Janelia Farm Research Campus
Ashburn, VA... 阅读全帖 |
|
a********0 发帖数: 5 | 3 不,他2002-2010直在mit
http://bme.med.tsinghua.edu.cn/index.php?option=com_content&tas
Sen Song received his B.A degree in Physics and Chemistry from University of
Mississippi in 1996, and Ph.D. degree in Neuroscience from Brandeis
University under Professor Larry Abbott, Waltham, USA, in 2002. For his PhD
thesis, he worked on computational models of spike-timing dependent
plasticity (STDP). During the year 2001 to 2002, he worked as a
computational biologist at GPC Biotech in Waltham, USA, working o... 阅读全帖 |
|
b********n 发帖数: 38600 | 4 More Than 400 Writers Sign Petition Protesting Donald Trump
http://www.nytimes.com/2016/05/25/us/politics/stephen-king-writ
Here is a complete list of ‘writers’ to studiously avoid:
Mark Slouka – Brewster, NY
Andrew Altschul – Fort Collins, CO
Jennifer Egan – Brooklyn, NY
Gregory Pardlo – New York, NY
Geraldine Brooks – West Tisbury, MA
Junot Díaz – Cambridge, MA
Tobias Wolff – Stanford, CA
Stephen King – Bangor, ME
Richard Russo – Portland, ME
Amy Tan – San Francisco, CA
ZZ Packer – San Francis... 阅读全帖 |
|
l****z 发帖数: 29846 | 5 乌克兰基辅——周二,在议会进行不信任投票决定是否剥夺乌克兰总理米克拉·阿扎罗
夫(Mykola Azarov)权力前的几个小时,阿扎罗夫宣布辞职。
支持政府的地区党(Party of Regions)在周二也和反对派议员站在了一起,废除了最近
颁布的一系列限制言论自由和集会的法律中的大部分。
阿扎罗夫的辞职和法律的废除是陷入困境的乌克兰总统维克多·F·亚努科维奇(Viktor
F.Yanukovich)做出的重大让步,同时也明显表明反对亚努科维奇的力量在积聚。
亚努科维奇在一份声明中表示,他已经接受阿扎罗夫的辞职申请,并签署政令,解雇内
阁的其他人员。但他表示,阿扎罗夫和各个部长将继续留任,直到议会通过一个新的内
阁。
亚努科维奇还承诺作出其他让步,包括赦免被逮捕的抗议者,成立委员会,修改宪法,
削弱总统权力。议员们将于周三开始处理这些事务。
在抗议活动席卷乌克兰的两个月期间,阿扎罗夫一直是亚努科维奇的坚定盟友。但无论
是他的辞职还是限制性法律——反对派称之为“独裁法律”——的废除都被视作旨在安
抚抗议者的举措。
但这些让步会迫使和抗议活动有关联的议会反对派领导人采取行动缓和局... 阅读全帖 |
|
b********n 发帖数: 38600 | 6 【 以下文字转载自 Military 讨论区 】
发信人: beijingren (to thine own self be true), 信区: Military
标 题: 美国文科生造反了
发信站: BBS 未名空间站 (Thu May 26 09:42:03 2016, 美东)
More Than 400 Writers Sign Petition Protesting Donald Trump
http://www.nytimes.com/2016/05/25/us/politics/stephen-king-writ
Here is a complete list of ‘writers’ to studiously avoid:
Mark Slouka – Brewster, NY
Andrew Altschul – Fort Collins, CO
Jennifer Egan – Brooklyn, NY
Gregory Pardlo – New York, NY
Geraldine Brooks – West Tisbury, MA
Junot Díaz – Camb... 阅读全帖 |
|
d*****r 发帖数: 2583 | 7 Sabatini和Svoboda师徒同时获奖,真是可喜可贺。
2002-2003
Liqun Luo, Ph.D., Stanford University
Single Neuron Labeling and Genetic Manipulation in Mice
Luo is working on a genetic method to manipulate and trace single neurons in
mice to learn how neural networks are assembled during development and late
r modified by experience.
A. David Redish, Ph.D.; Babak Ziaie, Ph.D.; and Arthur G. Erdman, Ph.D., Uni
versity of Minnesota
Wireless Recording of Neural Ensembles in Awake, Behaving Rats
The collaborators-a neuro |
|
p*******r 发帖数: 4048 | 8 BTW, our lab (Karel Svoboda at CSHL) find spine turnover in both young and
adult animals. So I think synapse turnover is pretty established but not much
research has been done on it.
Interestingly, the average density of synapse doesn't change.
It will be published in Nature this month.
Silent synapse is a bit controvesial, there are reports of presynaptic
mediated silent synapse due to pulse length/ amount of glutamate release.
But there is recent evidence from Malinow lab showing delivery of G |
|
p*****n 发帖数: 981 | 9 ☆─────────────────────────────────────☆
nniu (F5) 于 (Sun Jan 14 20:18:55 2007) 提到:
美国也搞科研统筹,这不,由于那个NIH的头就是搞Imaging的,所以他一上台就疯狂强
调imaging的重要性。这些年
做跟imaging有关的专业就很热门,做的人也算赶上了好时候。比如做晶体结构,受体
模拟重建,突触
communication,单分子跟踪等等,都是在这种统筹规划下的产物。那个位于Virginia
的Janelia Farm就是最大的最
明显的产物。前两天听了那个做synapse imaging的Svoboda的talk,他据说是该领域的
绝对明星,听完感觉这个
synapse imaging还太初级,而且结果大都是建立在shaky的观测结果之上的,打一个形
象的比喻,就象以前从火星上
拍下来的人脸地形,从各个角度看怎么看怎么象人脸,可后来机器人被送到火星并用高
清数码相机拍照,才发现根本不
是人脸而是地表形状形成的视觉假象。在生物学领域影像学非常重要,但如果人为的把
影像学炒成热门学科,不遗 |
|
p*****n 发帖数: 981 | 10 谢谢大家的关心,我戒网两周原因见听svoboda的talk的帖子,跟myresearch没有关系。
i won't comment on anything myresearch talked about me.
Today, when i was washing my coverslips for immunostaining (imaging :))
experiments. i suddenly understand, damn! so stupid was I . why immunost
aining couldn't be called imaging???
yes, of course, it can! my arguments with nniu, peoplem and peepal were
pointless and stupid. i did some retrospective thoughts on myself.
i did make a stupid mistake about this discuss about imaging.
太钻牛角尖了。以致于不 |
|
n**u 发帖数: 16 | 11 不会吧,俺发了那两篇关于imaging的帖子后就没再看了,因为俺不是做neuroscience
的,心里没底,也争不过你们:-))。今天看了一下,没想到后面引发大伙对imaging的
讨论,还导致云彩戒网2周,哎,道歉就言过了,大伙都是瞎聊聊,消消气。
讲老实话,我在看Axel在karolinska给的那个talk之前还真不知道嗅觉怎么研究,我想
从鼻腔研究起,再到神经,再到大脑皮层,这怎么搞啊,这得杀多少老鼠才行啊。可没
想到人家就用荧光标记蛋白,然后把老鼠放到一个密封的罐子里,给老鼠闻不同的气味
,5-30分钟后取出来,切片,看荧光蛋白的分布,那些跟不同气味有关联的神经元,
竟然就被他们给整出来了。真是开眼,我心说幸亏这个通路比较简单,否则搞一辈子都
没个头绪。
河马和Kendell说的好,搞神经,就要one cell at a time。Svoboda现在风头很健,但
是他那个玩艺能玩多久就很难讲了,因为那个系统本身就不是很干净。
大伙接着玩! |
|
p*****m 发帖数: 7030 | 12 你是要circuit+behavior是吧 那纯发育的就不说了 偏计算得也不说了Dulac/Zuke
r/Tank/Jessell/Axel/Svoboda/Anderson/Heintz/Palmiter 感觉都还reasonable吧
应该没有明显的坏人 |
|
a******e 发帖数: 247 | 13 领导的朋友要找POSTDOC,版上有人熟悉这些LAB的情况吗,工作环境是否良好?
======
Karl Deisseroth
Associate Professor of Bioengineering
Associate Professor of Psychiatry and Behavioral Sciences
Department of Bioengineering
Stanford University
======
Karel Svoboda
HHMI's Janelia Farm Research Campus
========
Thomas C. Südhof
Institute for Neuro-Innovation & Translational Neurosciences
Stanford School of Medicine |
|
|
|
i******u 发帖数: 937 | 16 这也太夸张了吧,看了一下此人的文章。也没什么了不起阿。假如他的实验室需要3个
neuron。 或是Nature。那么Lily Jan实验室需要什么?还有roger Nicoll, Malanka
RC, Richard Hunganir, solomon syder, David clapham实验室。。。。太多了,哪有
这么多有neuron, nature的人阿. |
|
w***t 发帖数: 303 | 17 热门实验室嘛
你说的那些实验室哪有ks热门
Malanka |
|
p*******r 发帖数: 4048 | 18 KS还好啦,基本一年2-3篇CNS,算高产了。
Malanka |
|
|
w****8 发帖数: 36 | 20 主要是他做的东西代表这systems neuroscience的主流方向,很多技术和软件都室他实
验室开发出来的,所以如果进去能做出东西来得话,基本上很容易找到位子,所以很难
进啊,不知道大家是不是这么认为的。 |
|
w***t 发帖数: 303 | 21 唉,ks做的哪能叫做systems neuroscience
也就是这几年想往上靠而已 |
|
a********k 发帖数: 2273 | 22 关键那些实验室做出东西来了肯定不比KS出来的难找工作啊 |
|
p*******r 发帖数: 4048 | 23 难进主要是因为他在janelia, 只能有6个博后。
所以一年基本一个机会。想去的人光我知道的每年都不下10个吧。 |
|
w****8 发帖数: 36 | 24 啊? 只能有六个? 那自己带fellowship的算不算? |
|
l******i 发帖数: 14 | 25 应该不算吧。 之前有个日本人之前在liqun luo实验室的,刚发了篇nature,在ucsd找
到了个位置。那个人好像去sk实验室
之前,有两篇cell,一篇nature,全是一作啊,真是猛。 |
|
z**a 发帖数: 36 | 26 他成名时可不做system,现在倒是在慢慢转向那边。
他们大部分技术都不是original自己发展的,不过很快就从别人手上学会了,做得又快
,把风头都抢走了。
能进他实验室当然就基本保证job了,就是要一心一意多多工作了。 |
|
w***t 发帖数: 303 | 27 cynical一把吧
就从最近这片nature来看
这日本哥们也就是摸个系统的皮毛而已
ks实验室这种搞法,也就是往外输送三脚猫faculty
技术fancy,内容空洞 |
|
w****8 发帖数: 36 | 28 很多人去的目的就是学这些技术啊,等自己有lab了,就不会有技术上的障碍了。 |
|
|
|
N*S 发帖数: 783 | 31 还有Axel实验室的,Svoboda实验室的,今年上market的真恐怖。。。 |
|
s**********y 发帖数: 23 | 32 小弟看了他的洋文简介,看了两遍也云里雾里的。哪位熟知的前辈能用讲解一下吗?我
看neurotree里他弟子很多独立了,是不是他做的内容蛮热门的? |
|
j*****d 发帖数: 787 | 33 synaptogenesis?
I think it is indeed very sexy. |
|
s**********y 发帖数: 23 | 34
感觉他不怎么做分子层面的东西啊. 其实他要觉得神经-行为方面的哪个具体问题? |
|
p*******r 发帖数: 4048 | 35 He applies two-photon microscopy to many problems.
Currently he is interested in how circuits in barrel cortex work. |
|
p*******r 发帖数: 4048 | 36 He used to work on that. But he gave that field to his former postdocs now. |
|
E********8 发帖数: 22 | 37 possible publication list for people graduated since 2010
118 伊成器
1. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-
associated FTO.
Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG
, He C.
Nat Chem Biol. 2011 Oct 16;7(12):885-7. doi: 10.1038/nchembio.687.
2.Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Sun F, Zhou L, Zhao BC, Deng X, Cho H, Yi C, Jian X, Song CX, Luan CH, Bae T
, Li Z, He C.
Chem Biol. 2011 Aug 26;18(8)... 阅读全帖 |
|
m*****l 发帖数: 28 | 38 Publication 惨不忍睹, Pubmed: Gray NW
3篇first-author文章。2005年的文章Figure 5还是错的,2003年的文章Figure 3 ps
的不行。
不是这个领域的,看不出来造假没有。
谁要是找出来我给谁发包子。
奇怪了,这样的人怎么能当上Nature的editor去把握这个领域的最前沿。
A dynamin-3 spliced variant modulates the actin/cortactin-dependent
morphogenesis of dendritic spines.
Gray NW, Kruchten AE, Chen J, McNiven MA.
J Cell Sci. 2005 Mar 15;118(Pt 6):1279-90. Epub 2005 Mar 1.
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5
and Homer.
Gray NW, Fourgeaud L, Huang B, Chen J, C... 阅读全帖 |
|
p*******r 发帖数: 4048 | 39 我这个悲观主义是向我以前老板Karel Svoboda学的。
他当年拿着HHMI,爽得很,他居然给我们说,经济不好呀,我很担心,于是申请了个
NIH R01. 然后两年后HHMI宣布across board 20% cut。人家哀嚎,他偷偷笑。
又过两年,他说我担心美国财政,于是跑Janelia Farm去了,后来的故事,我就不用说
了吧。。。 |
|
发帖数: 1 | 40 Tumour Biol. 2016 Jul 27. [Epub ahead of print]
Overexpression of long non-coding RNA TUG1 predicts poor prognosis and
promotes cancer cell proliferation and migration in high-grade muscle-
invasive bladder cancer.
Iliev R1, Kleinova R1, Juracek J1,2, Dolezel J3, Ozanova Z1, Fedorko M4,
Pacik D4, Svoboda M1,2, Stanik M5, Slaby O6,7.
my Email: [email protected]/* */
Thank you very much. |
|
f**d 发帖数: 768 | 41 老大,能否写详细点
你这样的写法,除了知道KAREL的,还是不了解他干了什么、牛在哪里、为啥牛。
域也
His
circ
the
neuroscienc
Bio
and
ki
postd
syn
Pr |
|
|
h******e 发帖数: 1385 | 43 参观过Janelia Farm Research Campus,感觉傻有钱,整得跟艺术博物馆似的 |
|
m***f 发帖数: 1622 | 44 其实对于愿意终生投身于科研的、又有优秀才能的人
那里是个世外桃源 |
|
|
|
n***w 发帖数: 2405 | 47 我一开始想,以后还是想研究AD/PD的,farm里好多都是neural circuit的,我搞不定。
现在不知道以后会做什么方向,现在做的是retina的neuroprotection,想做得基础一
些。
但是以后不想搞retina了。 |
|
m***f 发帖数: 1622 | 48 要做就做和疾病临床或工业应用相关吧
基础的很难存活
FARM的目标也是以应用为前景
定。 |
|
|
|