q**j
发帖数: 10612 | 1 我的是ubuntu intrepid ibex and R 2.7. 打算通过StatET plug-in 来用eclipse写和
运行R。
恕我愚昧，我没有办法找到r-base这么一个file。在synaptic package manager 里面
明明是有的。好像在usr/share里面。但是根本找不到。请问这个东西在哪里？（我运
行R挺好的，没有问题。）
另外还有一个小问题。我给eclipse做了一个launcher。一切顺利。但是ubuntu给这个
launcher的icon很不爽。打算换成eclipse 3.4的菱形的icon。可是找到的都是eclipse
3.2这样的圆形的icon。不太甘心。请问eclipse 3.4这样的菱形的icon应该是一个单
独的image吧？然后eclipse 吧这个Image和executable file连在一起。我也打算这样
。可是居然找不到这个菱形的image！请教一下怎么个搞法？多谢。 |
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I*******e
发帖数: 1879 | 2 ☆─────────────────────────────────────☆
qqzj (小车车) 于 (Fri Feb 20 18:51:14 2009) 提到:
我自己安装了一个3。4。把java, c++和其他乱七八糟的东西都搞好了。但是突然发现
ubuntu鬼鬼祟祟地给我安装了一个3.2。这个3.2不好用，update and install plug-in
都不方便，所以我想去了它。但是ubuntu认这个，在synaptics package manager里面
有户口，如果要去掉还挺麻烦。反而是我自己高的好好的3.4像是一个黑户口的。（
eclipse本来就应该这样吧？）请问这种情况下怎么作好？
☆─────────────────────────────────────☆
yangcheng (牛魔王) 于 (Fri Feb 20 19:28:55 2009) 提到:
如果workspace不一样不影响吧
装4个5个也没关系.
in
☆─────────────────────────────────────☆
blueivan (bl.ue |
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y***n
发帖数: 99 | 3 Eric Kandel, Center for Neurobiology and Behavior, Columbia University,
New York, is rewarded for his discoveries of how the efficiency of
synapses can be modified, and which molecular mechanisms that take
part. With the nervous system of a sea slug as experimental model
he has demonstrated how changes of synaptic function are central
for learning and memory. Protein phosphorylation in synapses plays
an important role for the generation of a form of short term memory.
For the development of a lo |
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y***n
发帖数: 99 | 4 ERIC KANDEL
Sea slug, a model system for learning
A phosphorylation of proteins has great importance also for the
discoveries for which Eric Kandel is rewarded, that is for
revealing molecular mechanisms, important for the formation of
memories. Eric Kandel started to study learning and memory in
mammals, but realized that the conditions were too complex to
provide an understanding of basic memory processes. He therefore
decided to investigate a simpler experimental model, the nervous
system of |
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M*****n
发帖数: 16729 | 5 i think in terms of synaptogenesis the neuro-muscular junction is well studied
in mice. so if one wants to study fish, he should definitely go for the
synaptogenesis in CNS.
Retino-tectal projection is a good system to study axon guidance. so is it for
the study of synaptic plasticity too. If i am gonna do that, probably I will
avoid those hot spots. In fact, our lab is gonna study the reticulo-spinal
curcuits in zebrafish. So I guess the synapsis formation in spinal cord may be
worth studying. |
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p*******r
发帖数: 4048 | 6 I don't know much about pharmacology but I study neuroscience. I think
Synaptic Transmission is far from being figured out. So there is still a lot
to do there and it is certainly the forefront. There is also a lot to do about
how certain channels are expressed in certain cells. How do the neuron know
how to choose a certian combination of channels to express, how are channels
targeted. Also a lot to do about how channels are modified during plasticity.
I think the hot thing is to combine with m |
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O******e
发帖数: 4845 | 7 ☆─────────────────────────────────────☆
lanceandfei (La Jolla的云彩) 于 (Wed May 23 18:58:37 2007) 提到:
Journal Club 挽救老年痴呆症的希望 1
Recovery of learning and memory is associated with chromatin remodelling.
Nature. 2007 May 10;447(7141):178-82.
前期工作： Opposing roles of transient and prolonged expression of p25 in
synaptic plasticity and
hippocampus-dependent memory.
Neuron. 2005 Dec 8;48(5):825-38.
Aberrant Cdk5 activation by p25 triggers pathological events leading to
neurodegeneration and
neurofib |
|
l******i
发帖数: 14 | 8 查了下，原来tonegawa在90s就跟钱卓在cell上这么搞了一次。
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic
plasticity in spatial memory.
Tsien JZ, Huerta PT, Tonegawa S.
Cell. 1996 Dec 27;87(7):1327-38.
PMID: 8980238 [PubMed - indexed for MEDLINE]
Related articles
Subregion- and cell type-restricted gene knockout in mouse brain.
Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, Mayford M,
Kandel ER, Tonegawa S.
Cell. 1996 Dec 27;87(7):1317-26.
PMID: 8980237 [PubMed - indexed for MEDLIN |
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p*****m
发帖数: 7030 | 9 这个我知道 我的意思是说 最接近市场的还是小分子药 这样那些繁琐的mechanism用处
很值得怀疑 比如说吧 depression这东西 现在paper里扯得上的东西太多了 从neural
stem cell, neurogenesis到synaptogenesis 到synaptic plasticity，到n种neurotra
nsmitter system和brain region blabla。。这些七七八八的东西我看来都很可疑 |
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a**p
发帖数: 49 | 10 Neural bases for addictive properties of benzodiazepines p769
Benzodiazepines, such as valium, are used both in clinics and for
recreational purposes, but lead to addiction in some individuals. Addictive
drugs increase the levels of dopamine and trigger synaptic adaptations in
the mesolimbic reward system, but the neural basis for the addictive nature
of benzodiazepines remains elusive. Here, they are shown to increase firing
of dopamine neurons in the ventral tegmental area through GABAA recept |
|
j*******8
发帖数: 933 | 11 Dear DaNiu in Neuroscience, help me please!!!!
I'm testing protein interaction in the post-synaptic density (PSD) fraction
of brain tissue. Usually, we use 1% SDS to dissolve the PSD pellet. However,
we're now planning to test protein interaction with IP. So, my questions
are: does 1% SDS interupt protein interaction? if does, what should I use to
dissolve PSD? Many thanks (and baozi if I have any). |
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j*******8
发帖数: 933 | 12 Ru-Ti.
I'm testing protein interaction in the post-synaptic density (PSD) fraction
of brain tissue. Usually, we use 1% SDS to dissolve the PSD pellet. However,
we're now planning to test protein interaction with IP. Can anyone tell if
1% SDS interupt protein interaction? what about 0.1%?
Thanks! |
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d*****r
发帖数: 2583 | 13 希望生物里面多一些说No的文章，不要搞得什么东西都跟什么东西相关。
Science 5 March 2010:
Vol. 327. no. 5970, pp. 1250 - 1254
Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte
Ca2+ Signaling
Cendra Agulhon,1,* Todd A. Fiacco,2 Ken D. McCarthy1
The concept that astrocytes release neuroactive molecules (gliotransmitters)
to affect synaptic transmission has been a paradigm shift in neuroscience
research over the past decade. This concept suggests that astrocytes,
together with pre- and postsynaptic neuronal |
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w******n
发帖数: 168 | 14 不过wnt主要的component基本都发现了 就像Nusse同学今年NAS了一样
剩下的像PCP好像主要component也发现的差不多了
像wnt在传统发育学 在果蝇 线虫 斑马鱼 fogg的role基本都比较清楚了
但是关键是“老药新用”比如当时Zou yimin做出来在axon guidance中的作用
或者在synaptic genesis的作用
或者除了体轴发育这种粗调作用外 在local environment中niche的微调作用
我觉得还是很有搞头
beta |
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p*******r
发帖数: 4048 | 15 I think soon, with trans-synaptic tracing and calcium imaging tools. |
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h****i
发帖数: 204 | 16 偶尔听人说他还不错，好像NIDCD就他做synaptic physiology吧，他自己觉得没人讨论。我不是很熟悉他，只是见过两面聊了几句。 |
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h******e
发帖数: 354 | 17 【 以下文字转载自 Overseas 讨论区 】
发信人: hudapple (apple), 信区: Overseas
标 题: Postdoctoral/Predoctoral Research Associate available
关键字: Postdoc,SUNY-Buffalo,Biology
发信站: BBS 未名空间站 (Thu Oct 21 15:54:50 2010, 美东)
Postdoctoral/Predoctoral Research Associate Positions are available in the
laboratory of Dr. Zhen Yan in Department of Physiology and Biophysics, State
University of New York at Buffalo.
Our research goal is to understand the synaptic action of various neuromodulators that are linked to mental heal... 阅读全帖 |
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n***w
发帖数: 2405 | 18 Title:Synaptic rewiring for topographic mapping and receptive field
development.
PMID:20176460
please send to n***[email protected]
Thank you. |
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s********6
发帖数: 89 | 19 Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions
Using trans-Synaptic Enzymatic Biotinylation p456
Amar Thyagarajan, Alice Y. Ting |
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s******y
发帖数: 28562 | 20 http://www.sciencemag.org/cgi/content/abstract/science.1195298
Published Online October 28, 2010
Science DOI: 10.1126/science.1195298
Science Express Index
Reports
Calcium-Permeable AMPA Receptor Dynamics Mediate Fear Memory Erasure
Roger L. Clem and Richard L. Huganir*
Traumatic fear memories can be inhibited by behavioral therapy or extinction
training in rodent models, but are prone to relapse. Under some conditions,
however, these treatments generate a permanent effect on behavior
sugges... 阅读全帖 |
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l***n
发帖数: 42 | 21 or any lab is doing this? I mean both pre and post-synaptic recording in
interneurons? |
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p*****m
发帖数: 7030 | 22 不知道有没有上Mitbbs的哥们 hoho 看来至少北大不会把门槛提高哈
# Yuhui Whitney Yin，Ph.D 主讲 The mitochondria connection: from human
diseases to drug design
11:30 - 12:30, Dec. 15, 2010, Wed. 生命科学学院411会议室
# Wei Lu ，Ph.D 主讲 single-cell genetic analysis of synaptic glutamate
receptors
09:30 - 10:30, Dec. 15, 2010, Wed. 生命科学学院411会议室
# ZhuchengChen，Ph.D 主讲 Structure and Control of the ActinRegulatory WAVE
Complex
08:30 - 09:30, Dec. 15, 2010, Wed. 生命科学学院411会议室
# Dongyi Xu，Ph.D 主讲 Bloom’s Syndrome, genomic instability and cance... 阅读全帖 |
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d*****r
发帖数: 2583 | 23 大家不要吵了，读读这篇老帖子，娱乐一下。。
我第一次读到是刚来美国不久，今天偶然又翻到，觉得peoplem的这个校友
(Alyce Su)还是很有趣的，虽然里面很多东西跟今天的世界已经差别很大了。
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
jsj 贴于2004/07/25 12:12
《从加州理工到高盛银行》 -- 粟耀莹
Why -- California Institute of Technology to Goldman Sachs
Adventure of Alyce Su
CalTech，PIMCO，McKinsey，Goldman Sachs
so that I get to see Larry Ellison !!!!!
[1] 前言
[2] 19 岁走出台湾赴美
[3] 进入加州理工
[4] 从物理转生物科技
[5] 得到芯片之父 Carver Mead及诺贝尔奖得主 Rudi Marcus的鼓励
[6] 到生物系找指导教授
[7] 我做出了一个经典生物物理模型
[8] 我用... 阅读全帖 |
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b******k
发帖数: 2321 | 24 谢谢哈 请问你说Ed在science上没有帮助是啥意思呢？我感觉他还挺聪明的人 最近做
那个rabies的trans synaptic tracer看着还挺靠谱的呀
. |
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a********k
发帖数: 2273 | 25 Glanzman DL, Kandel ER, Schacher S (1990) Target-dependent structural
changes accompanying long-term synaptic facilitation in Aplysia neurons.
Science 249:799–802.
Montarolo PG, Goelet P, Castellucci VF, Morgan J, Kandel ER, Schacher S (
1986) A critical time window for macromolecular synthesis in long term
heterosynaptic facilitation in Aplysia. Science 234:1249 –1254. |
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j*****d
发帖数: 787 | 26 哈哈。乐死了。人家要动物模型吧
自己补充性地再了解了一些，很多独立性工作哦
https://sfari.org/current-grant-recipients/-/asset_publisher/Qv9z/content/
the-role-of-shank3-in-autism-spectrum-disorders?redirect=%2Fcurrent-grant-
recipients
The role of SHANK3 in autism spectrum disorders
Mount Sinai School of Medicine
The relationship between genetics and autism is not always straightforward,
but some autism spectrum disorders are known to be caused by defects in a
single gene. These simpler cases give researchers the opportunity to cre... 阅读全帖 |
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s******y
发帖数: 28562 | 27 呵呵，我就不去趟这种浑水了。
我就是查文献的时候看到有的实验室已经在做PTEN在autism里面的功能，
觉得挺纳闷的。
就像你说的那样，大部分功能特别重要的基因（那些很多都是oncogene)，
在neuron 里面都肯定有功能的。
比方说我要是发个神经在纹状区把tubulin KO了，几乎也肯定能够产生
autism 症状吧？可是这么做有意义么？
SHANK3, 和Neuroligin 的意义在于他们是非常组织特异性的蛋白，
在基因上搞乱这两个蛋白后产生的形状主要集中在神经和行为上，
这个和autism 病人的特点一致。因为autism 病人主要是行为异常，
其他发育大致都还正常。
而PTEN这种蛋白，在自然情况下不管是以什么方式被搞乱（比方说基因
突变，或者mis-regulation)，其表型不太可能集中在脑部，所以不太可能是
autism 的致病原因。
在这个意义上来说，我觉得对SHANK3, Neurologin等几个post-synaptic
scaffold protein 的调控，才是最有可能的autism 的致病原因。 |
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h*******v
发帖数: 27 | 28 I read that paper sometime ago. It's a little odd that they examined
striatum instead of cortex. They tried to make a story that cortico-striatal
synapses were sick and other regions were spared (they examined synaptic
plasticity in hippocampus and found it is alright, if I remember correctly).
If so, they should at least rescue the striatum region with virus-delivered
shank3. Without the rescue experiment, no causality is established and the
autistic phenotype could simply be the combined secon... 阅读全帖 |
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d*****r
发帖数: 2583 | 29 http://www.hhmi.org/news/popups/isrf_pop.html
2011 International Student Research Fellows
Institution Student Advisor Discipline
Boston University Wei Guo
China Barbara Shinn-Cunningham Systems and computational
neuroscience
Brandeis University Marcus Long
United Kingdom Lizbeth Hedstrom Protein degradation using chemical
biology
California Institute of Technology Andreas Hoenselaar
Germany Thanos Siapas Spatial mapping in the hippocampus using
virtual
reality... 阅读全帖 |
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g****y
发帖数: 26 | 30 【 以下文字转载自 Postdoc 讨论区 】
发信人: galupy (Galoppogos-horse), 信区: Postdoc
标 题: postdoc opening@Sloan-Kettering Institute
关键字: postdoc opening,sloan kettering
发信站: BBS 未名空间站 (Sun Aug 14 14:28:02 2011, 美东)
We are seeking highly motivated individuals for postdoctoral positions in
the Structural Biology Program of the Sloan-Kettering Institute, Memorial
Sloan-Kettering Cancer Center, NYC, USA.
The lab develops cutting-edge techniques (Nature,doi:10.1038/ nature09163 (
2010)) aimed at gaining a mechanisti... 阅读全帖 |
|
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W*****o
发帖数: 1780 | 32 去查了一下，张旭总共发表了90多篇英文文章（不算中文）。回国之后作为联系作者也
有快20篇了。其中有cell, neuron, Journal of neuroscience, PNAS 好多篇。而且他
1995年就回国了，那个时候国内的环境有多差不用说了吧。这也快20年了。比饶益2007
年才全职回去多了12年。比起培养的中国学生也多多了，算国内贡献肯定不会小。如果
他一直留在国外，成就未必就比饶差。谁把饶益的文章列一列。国内多少篇，总共多少
篇，培养了多少中国学生？
1. Li KC, Wang F, Zhong YQ, Lu YJ, Wang Q, Zhang FX, Xiao HS, Bao L, Zhang X
. (2011) Reduction of follistatin-like 1 in primary afferent neurons
contributes to neuropathic pain hypersensitivity. Cell Res, 21: 697-699.
2. Li KC, Zhang FX, Li CL, Wang F, Yu MY, Z... 阅读全帖 |
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s*********t
发帖数: 600 | 33 没人转这个咩？老Poo的2012年新年报告
版主给m下，再给一个包子吧：）
——————————————————————
科学追求的事实和谬论——2011中科院神经所年会蒲慕明所长报告
方琪
今年的神经所年会蒲慕明所长的报告继续由我根据录音整理，不知是不是独家，在年末
愿与有志于科学的同学们共勉~^^
科学追求的事实和谬论
Facts and Fallacies in Science
Mu-ming Poo
2011.12.29 16:30-17:15
好，我们今年年会非常热烈，大家都看到了，我们年年有进展，今年很多进展的报告大
家都觉得很兴奋，我想先讲今年所里几件大事吧，第一件大事是现在所里的领导增加了
鲜血，大家可能还不知道，王燕老师是我们所里正式的学术副所长，舒友生老师是我们
的党委副书记[在座一同学说道：“舒老师今天实验室来了新样品，估计在做实验今天
……”]，还有王佐仁老师是所长助理，我们最近又来了几个新的师长，最新的是昨天
到的张翼凤老师，Harvard博士后，UCSD的PhD，有些同学听过她的报告，有些同学没有
听过，可以给她安排一场，晚上的seminar.
下面为大家讲... 阅读全帖 |
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p*****m
发帖数: 7030 | 34 不喜欢
没人转这个咩？老Poo的2012年新年报告
版主给m下，再给一个包子吧：）
——————————————————————
科学追求的事实和谬论——2011中科院神经所年会蒲慕明所长报告
方琪
今年的神经所年会蒲慕明所长的报告继续由我根据录音整理，不知是不是独家，在年末
愿与有志于科学的同学们共勉~^^
科学追求的事实和谬论
Facts and Fallacies in Science
Mu-ming Poo
2011.12.29 16:30-17:15
好，我们今年年会非常热烈，大家都看到了，我们年年有进展，今年很多进展的报告大
家都觉得很兴奋，我想先讲今年所里几件大事吧，第一件大事是现在所里的领导增加了
鲜血，大家可能还不知道，王燕老师是我们所里正式的学术副所长，舒友生老师是我们
的党委副书记[在座一同学说道：“舒老师今天实验室来了新样品，估计在做实验今天
……”]，还有王佐仁老师是所长助理，我们最近又来了几个新的师长，最新的是昨天
到的张翼凤老师，Harvard博士后，UCSD的PhD，有些同学听过她的报告，有些同学没有
听过，可以给她安排一场，晚上的seminar.
下... 阅读全帖 |
|
e***o
发帖数: 344 | 35 I thought for FRET, it is 10 nm. How about split gfp/BiFC? Thanks！
People are using split GFP (called GRASP) to reconstruct pre/post synaptic
split GFP and get good signal. The distance of synapse is around 20-40nm.
The extracellular part of XFG isnt big. I am wondering 10nm is good for split gfp/BiFC?
low |
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g***y
发帖数: 201 | 36 Brain Cell Biol. 2006 Jun;35(2-3):137-56. Epub 2007 Oct 4.
Synaptic destabilization by neuronal Nogo-A.
please send it to: p*****[email protected] |
|
