l**********1 发帖数: 5204 | 1 check his/her peer review papers CNS record except N sub and Cell sub only
CNS
especially the authorship position:
i mean from NCS only 1st author to last/corresponding author that PI
for example:
//www.lsi.umich.edu/facultyresearch/labs/xz-xu/publications
Publications
Articles
Piggott, B.J.*, Liu, J.*, Feng, Z.*, Wescott, S.A., and Xu, X.Z.S. (2011)
The neural circuits and synaptic mechanisms underlying motor initiation in C
. elegans. Cell 147, 922-933. PubMed
ignored
Feng, Z.*, Li, W.*, Wa... 阅读全帖 |
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R***k 发帖数: 20 | 2 The University of Massachusetts Amherst is seeking a highly motivated and
creative neuroscientist to join the laboratory of Dr. Geng-Lin Li in the
Department of Biology to study synaptic transmission at hair cell ribbon
synapses. This is a full-time Postdoctoral Research Associate position with
health insurance provided. Ph.D. in neurobiology or a related field and
three years experience with patch-clamp recording are required. Recent
graduates, within a year or two of receiving doctoral degree,... 阅读全帖 |
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l**********1 发帖数: 5204 | 3 3-4 Y
pls refer:
last/corresponding author of CNS and last CNS last author Sternberg then as
3rd author
Li, W., Feng, Z., Sternberg, P.W., and Xu, X.Z.S. (2006) A C. elegans
stretch receptor neuron revealed by a mechanosensitive TRP channel homologue
. Nature 440, 684-687. PubMed Link
Fist author of CNS
Xu, X.Z.S., & Sternberg, P.W. (2003) A C. elegans sperm TRP protein required
for sperm-egg interactions during fertilization. Cell 114, 285-297. PubMed
link:
//www.lsi.umich.edu/facultyresearch/l... 阅读全帖 |
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m*****l 发帖数: 28 | 4 Publication 惨不忍睹, Pubmed: Gray NW
3篇first-author文章。2005年的文章Figure 5还是错的,2003年的文章Figure 3 ps
的不行。
不是这个领域的,看不出来造假没有。
谁要是找出来我给谁发包子。
奇怪了,这样的人怎么能当上Nature的editor去把握这个领域的最前沿。
A dynamin-3 spliced variant modulates the actin/cortactin-dependent
morphogenesis of dendritic spines.
Gray NW, Kruchten AE, Chen J, McNiven MA.
J Cell Sci. 2005 Mar 15;118(Pt 6):1279-90. Epub 2005 Mar 1.
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5
and Homer.
Gray NW, Fourgeaud L, Huang B, Chen J, C... 阅读全帖 |
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A*******e 发帖数: 13 | 6 :转一个,听说还有些比较激进的言论没有收在文字稿里。
中科院神经科学研究所2012 年年会蒲慕明所长的讲话
谈灰色地带的科研诚信
2012 年12 月28 日
(根据录音整理)
一、前言
我今天想讲的主题是过去主题的延续。几年前我曾经谈过诚信的问题。科学
研究的诚信问题现在越来越重要。媒体上常有关于科学不端行为的报导,但事实
上明目张胆的科学不端行为(scientific misconducts),所谓伪造、篡改和剽窃
(Fabrication,Falsification,Plagiarism,简称FFP),是极少见的。现在最严重
的问题不是明显的FFP,而是灰色地带的诚信问题,就是那些不容易被发现、标
准不容易确定的问题。我们每一个从事科学研究的人都会遇到这些问题,都应该
认真考虑,当遇到这些问题时,怎么做才符合诚信的要求。
二、数据分析和表述时的灰色地带行为
今天我首先想讲的就是数据分析和表述时的不当行为。首先,较严重的就是
选择数据。只选择自己喜欢的结果,不喜欢的就不要。忽略不计对自己的结论有
威胁性的数据。第二,在发表文章或口头表述结果时不当地夸大表述。前者比较
容易判断是非,... 阅读全帖 |
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d*****n 发帖数: 433 | 7 The 2013 Gordon Research Conference on OXIDATIVE STRESS AND DISEASE that
expands on the theme The Metabolic – Inflammatory Axis in Brain Aging and
Alzheimer’s Disease will be held April 14-19th, 2013 at the Les Diablerets
Conference Center, Les Diablerets, Switzerland.
The conference is designed from an interdisciplinary perspective to provide
discovery, translational, and clinical scientists with the latest findings
on bioenergetic deficits and activation of inflammatory responses, their
redox ... 阅读全帖 |
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p*****c 发帖数: 20445 | 8 A-D E-K L-P R-Z
Peter Baumann, Ph.D.
HHMI Early Career Scientist
Stowers Institute for Medical Research
Peter Baumann’s research focuses on beginnings and endings: beginnings in
the form of reproduction in unisexual lizards and endings in the form of the
telomeres that protect chromosome tips.
Each time chromosomes are copied, telomeres—specialized stretches of DNA
that extend from the ends of each chromosome—become progressively shorter.
With each cell division, they ero... 阅读全帖 |
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s**i 发帖数: 4448 | 9 Language and human intelligence, in my opinion, is resulted from increased
neuroplasticity (capability of neurons to make new synaptic connections,
weed out weak connections, strengthen repeatedly activated connections) due
to several key gene mutations.
It's not that huge a leap biologically as you might think. A couple of
mutations would suffice. Human intelligence is simply a result of reaching a
critical threshold of brain wiring capability by evolution.
Neurons are like transistors, they fu... 阅读全帖 |
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i*****o 发帖数: 480 | 12 用western确认immunostaining的结果,看是不是表达量有差别。现在用的是tubulin,
但结果不consistent,而且看了相关的文献用的是actin比较多,所以想知道这里有没
有什么说法。 |
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m******5 发帖数: 1383 | 13 其实我觉得非特异带才是最靠谱的
大多数时候上样量差一点beta actin也是平的,反而非特异带如实反映了趋势差别 |
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l*****e 发帖数: 227 | 14 【 以下文字转载自 USTC 讨论区 】
发信人: sunnyday (胖头鱼。按斤卖就赚了), 信区: USTC
标 题: 陈路的最高水平的文章与她前夫毫无关系
发信站: BBS 未名空间站 (Wed Oct 16 00:49:15 2013, 美东)
这篇文章建立了她在领域里的地位,并直接导致了她后来拿到的天才奖。这篇文章以及
后来她围绕这个题材继续发的另外几篇文章都和她的前夫毫无关系(因为她前夫当时根
本就不在她那个实验室里)。
Stargazin regulates synaptic targeting of AMPA receptors by two distinct
mechanisms.
Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ,
Bredt DS, Nicoll RA.
Nature. 2000 Dec 21-28;408(6815):936-43.
他们的私人事情我不知道,但是麻烦那些wsn不要反复的就她的学术水平进行造谣。 |
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m******g 发帖数: 467 | 15 最近打算新开一个项目,正在集中阅读那方面文献,哈哈。
所以感觉很少看这些general的paper.
Science 14.07.18
推荐:
1. (recommended Elife paper) Genome rearrangements and pervasive meiotic
drive cause hybrid infertility in fission yeast
稍微了解一下:
1. Human tRNA synthetase catalytic nulls with diverse functions
2. Putting the genetic breaks on breeding
小知识:
1. How the worm changes its tastes
Synaptic PI3K is crucial for the behavioral switch caused by learning
2. Organogenesis in a dish: Modeling development and disease using organoid
techno... 阅读全帖 |
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g****z 发帖数: 822 | 16 Neuroscience, mental disorders, patch clamp, ion channels, glutamate
receptors, trafficking, synaptic transmission, biochemistry, molecular
biology, cell biology相关领域都行。有一些审稿经历 (自己有审,也经常帮老板审)
,但数量不够,现在申请EB1就审稿这一项比较弱,希望版上的朋友帮帮忙,万分感谢
!!
如有需要可提供简历和详细信息。
联系邮箱: j****[email protected]
非常感谢!! |
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d********r 发帖数: 3279 | 17 My thoughts so far:
I think the "uniqueness" of using optogenetics in invertebrates, worms in
particular, is still essentially related to the general advantages of using
this model organism in the first place: transparent, small size, simple
nervous system and genetic screens.
For ephys analysis of synaptic function in dissected preps using
optogenetics, there is no big difference between worms and mice. For whole
animal behavioral studies under light stimulation, worms under a LED is a
lot eas... 阅读全帖 |
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n***w 发帖数: 2405 | 18 aging领域一直很活跃的好吧。。。你不能说因为发了nature才说它活跃吧。。
我读了那个young blood的那篇,整体给我的感觉就是太jumpy了,也许是字数限制,好
多东西没交代清楚。有几个关键实验,可以再深挖一下,包括fractionation plasma,
看能不能identify是什么东西,另外就是plasma和synaptic plasticity的联系还没有
建立起来。。。 |
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s***5 发帖数: 453 | 19 email:a******[email protected]
Nutr Neurosci. 2014 Mar 28. [Epub ahead of print]
Postnatal nutritional iron deficiency impairs dopaminergic-mediated synaptic
plasticityin the CA1 area of the hippocampus.
Breton AB, Fox JA, Brownson MP, McEchron MD.
谢谢 |
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N******K 发帖数: 10202 | 20 可以把单个神经细胞当做一个单片机比如C8051
突触连接 changes in synaptic connections 是计算机总线 而不是 内存结构
can |
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m*********7 发帖数: 606 | 21 帮人发一下广告,若是大家有朋友熟人对此有兴趣的话,还请帮忙互相转告。
职位:博士后一名
机构:M.D.Anderson Cancer Center, 德州休士顿 (Houston, TX)
要求:博士学位;一作文章;Confocal microscopy 及/或 electrophysiology经验;
神经科学背 景为佳;鼓励新近毕业博士申请。
联系方式:The interested candidates should send a CV, 3-4 reference letters
and a research statement describing research interest and career goals to Dr
. David Grosshans at [email protected]
(function(){try{var s,a,i,j,r,c,l,b=document.getElementsByTagName("script");l=b[b.length-1].previousSibling;a=l.getAttribute('data-cfemail... 阅读全帖 |
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x********a 发帖数: 230 | 22 已拷贝复制整理以增加其可读性.欢迎大家不定期更新,帖子变长,但可通过查找方式找
一下自己感兴趣的老板在不在其中。
[转载]美国部分变态导师列表 按学校整理
此贴包含在美PHD STUDENT 和POSTDOC的各种杯具,转自MITBBS,原帖链接如下,
http://www.mitbbs.com/article_t/Biology/31350357.html
有人总结,四种PI不能碰,AP(assistant professor),F(female),C/T(Chinese/
Taiwanese), Unmarried.
当然这些都是一家之言,个人对这些说法持保留态度,细节需要继续探究。有一个标准
可以用于大家加入某lab之前的预先判断,就是PI的变态程度和lab里中国大陆人加上印
度人占总人数的比例成正比,因为大陆人和印度人都是典型的吃苦耐劳又老实(聪明与
否另说),所以要不是对这方面有特殊需求的PI,是不会故意招很多中国人和印度人的
,具体来说,这个比例在三分之一以内的,正常;三分之一到三分之二的,仍属正常,
只是人比较tough,可能订立了一些关于工作时间、进度的严格的规定;三分... 阅读全帖 |
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T*****e 发帖数: 247 | 23 说不了下一个热点,莫若说说现在的方向有哪些。
1. 开发工具
A. 监测神经活性
GCaMP到6是不是已经差不多了?但是Ca2+究竟能代表多少neuronal activity?
cAMP的sensor能代表多少?
传统的IEG能代表多少?缺点是什么?记得有人用MAPK磷酸化水平来估计neuronal
activity
几种非电生理的voltage sensor 好用吗?
B. 改变神经活性
大名鼎鼎的optogenetics
恒温动物不能用的温控通道TrpA1
最近热炒的磁感应,还有超声控制的
C. 更高解析度观察突触
几种突触活性区的marker
证明物理联系的比如split GFP
能不能不通过电镜观察synaptic cleft?
D. 各种活体成像 高端显微镜 通过影像(包括电镜)重建神经网络
高解析度
实时成像
快速扫描
高穿透性
2. 具体的问题(水平有限,说说自己熟一点的)
具体的行为模型:学习记忆,生物节律,睡眠,aggressive,mating,social
interaction,decision making, pain, fear, navigation,... 阅读全帖 |
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T*****e 发帖数: 247 | 24 说不了下一个热点,莫若说说现在的方向有哪些。
1. 开发工具
A. 监测神经活性
GCaMP到6是不是已经差不多了?但是Ca2+究竟能代表多少neuronal activity?
cAMP的sensor能代表多少?
传统的IEG能代表多少?缺点是什么?记得有人用MAPK磷酸化水平来估计neuronal
activity
几种非电生理的voltage sensor 好用吗?
B. 改变神经活性
大名鼎鼎的optogenetics
恒温动物不能用的温控通道TrpA1
最近热炒的磁感应,还有超声控制的
C. 更高解析度观察突触
几种突触活性区的marker
证明物理联系的比如split GFP
能不能不通过电镜观察synaptic cleft?
D. 各种活体成像 高端显微镜 通过影像(包括电镜)重建神经网络
高解析度
实时成像
快速扫描
高穿透性
2. 具体的问题(水平有限,说说自己熟一点的)
具体的行为模型:学习记忆,生物节律,睡眠,aggressive,mating,social
interaction,decision making, pain, fear, navigation,... 阅读全帖 |
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k*****d 发帖数: 177 | 25 诚心求各位同行前辈推荐审稿机会,万分感谢(有审稿经验)
研究方向:Neuroscience, Molecular and developmental biology
1: ion channel properties, neural circuits, drug discovery
2: synaptic plasticity, learning and memory, aging, alzheimer’s, parkinson
’s disease
3: protein-protein interactions during the development of brain and neurons
研究方式主要包括:
molecular biology,
electrophysiology patch-clamp recordings,
rodent surgeries and behavioral tests…
恳请各位前辈不吝赐教,已发表的文章IF从3-15不等,如果需要简历,可以单独奉上。
可通过email联系我:kk.ephys (AT) gmail.com
感激不尽。 |
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p******n 发帖数: 55 | 26 http://www.grc.org/amc.aspx
熟悉的名字不少啊
2016 Lecturers
◾Nieng Yan, Membrane Transport Proteins
◾Xiaowei Zhuang, Synaptic Transmission
◾Christopher J. Chang, Metals in Medicine
◾Mikhail Lukin, Quantum Science
2015 Lecturers
◾Karl Deisseroth, Amygdala in Health & Disease
◾David M. Sabatini, Lysosomal Diseases
◾Laura Kiessling, Carbohydrates
◾Gerbrand Ceder, Physical Metallurgy
◾Liang Fu, Superconductivity
2014 Lecturers
◾Kristi S. Anseth, Si... 阅读全帖 |
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发帖数: 1 | 27 Postdoctoral Positions Available
Two postdoctoral positions are immediately available for studies in
neurophysiology focusing on the role of voltage-gated potassium channels in
regulating hippocampal circuit development and function. The candidate will
be working with a team of highly interactive electrophysiologists and
molecular biologists at the Eunice Kennedy Shriver National Institutes of
Child Health and Human Development (NICHD), National Institues of Health (
NIH).
Skills and Qualifica... 阅读全帖 |
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发帖数: 1 | 28 审稿经验太少,诚心求各位前辈推荐审稿机会,不胜感激!
研究方向:Neuroscience and Molecular biology, glutamate receptors
trafficking, synaptic development.
如有需要可提供简历和详细信息。
联系邮箱: yuanqiuyuedui(AT)gmail.com
万分感谢! |
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v*******e 发帖数: 11604 | 29
long term synaptic plasticity可以存储记忆。 |
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l****y 发帖数: 398 | 30 not a high hand.
Even the macromolecule analysis is likely to be dominated by ESI now. MALDI
is more straightforward, but it
can't be coupled to LC. Years ago, our lab used MALDI most of the time. But
now, with orbitrap and synapt,
many people are switching to the electrospray. |
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s*****0 发帖数: 244 | 31 版上也没有人用waters Synapt traveling wave ion mobility的? |
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g****y 发帖数: 26 | 32 【 以下文字转载自 Postdoc 讨论区 】
发信人: galupy (Galoppogos-horse), 信区: Postdoc
标 题: postdoc opening@Sloan-Kettering Institute
关键字: postdoc opening,sloan kettering
发信站: BBS 未名空间站 (Sun Aug 14 14:28:02 2011, 美东)
We are seeking highly motivated individuals for postdoctoral positions in
the Structural Biology Program of the Sloan-Kettering Institute, Memorial
Sloan-Kettering Cancer Center, NYC, USA.
The lab develops cutting-edge techniques (Nature,doi:10.1038/ nature09163 (
2010)) aimed at gaining a mechanisti... 阅读全帖 |
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L****r 发帖数: 333 | 33 I am using XEVO and SYNAPT G2, please list your questions. |
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a*****e 发帖数: 97 | 34 Nice.
Tried on Synapts HRMS gives 222.0999 and search database did not give the
compounds have 406nm and 264nm maxim.
We even search the database called AntiBase and came with no success. Now
understand the untargeted analysis is no easy. |
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a*****e 发帖数: 97 | 35 Nice.
Tried on Synapts HRMS gives 222.0999 and search database did not give the
compounds have 406nm and 264nm maxim.
We even search the database called AntiBase and came with no success. Now
understand the untargeted analysis is no easy. |
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W***n 发帖数: 11530 | 36 You have a bright future, just gain some experience and return home to kick
off a long lasting rewarding career.
Here are a list of semi companies involved in mixed-sginal IC:
ACCO Semiconductor, Inc. Actions Semiconductor Co., Ltd. Adapteva, Inc.
Advanced Micro Devices, Inc. (AMD) Aeroflex Colorado Springs Altera
Corporation
Ambarella, Inc. Ambiq Micro Inc. AMIMON Ltd.
ams AG Analog Devices, Inc. (ADI) Analogix Semiconductor, Inc.
Apexone Microelectronics Applied Micro Circuits Corporation (App... 阅读全帖 |
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s***d 发帖数: 15421 | 37 ceo说已经基本谈妥了 110 一股 现在才75一股 尼玛 50% 溢价
★ 发自iPhone App: ChineseWeb 1.0.6
★ 发自iPhone App: ChineseWeb 1.0.6 |
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m*****t 发帖数: 3477 | 38 东芝把除NAND外的所有semi业务挂牌出售,我兔应该能收不少。
FCS看来也是准备弃暗投明了。 |
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g********7 发帖数: 1145 | 39 溢价现在还这样多 看来市场暂时不相信110的价格 |
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g********7 发帖数: 1145 | 40 溢价现在还这样多 看来市场暂时不相信110的价格 |
|
s***d 发帖数: 15421 | 41 美国政府批不批是个大问题
★ 发自iPhone App: ChineseWeb 1.0.6 |
|
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s***d 发帖数: 15421 | 43 别嘲笑天朝校企 搞不好 A股ipo 翻个几番都有可能。说不定 synaptics 也成了校企。
★ 发自iPhone App: ChineseWeb 1.0.6
★ 发自iPhone App: ChineseWeb 1.0.6 |
|
c*****v 发帖数: 839 | 44 Valuation很低了,就是不知道OLED果子会不会用自己的Display Driver. |
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s***d 发帖数: 15421 | 45 我觉得 不一定
★ 发自iPhone App: ChineseWeb 11 |
|
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s***d 发帖数: 15421 | 47 追nvda都比买垃圾好
★ 发自iPhone App: ChineseWeb 11 |
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g****y 发帖数: 26 | 48 【 以下文字转载自 Postdoc 讨论区 】
发信人: galupy (Galoppogos-horse), 信区: Postdoc
标 题: postdoc opening@Sloan-Kettering Institute
关键字: postdoc opening,sloan kettering
发信站: BBS 未名空间站 (Sun Aug 14 14:28:02 2011, 美东)
We are seeking highly motivated individuals for postdoctoral positions in
the Structural Biology Program of the Sloan-Kettering Institute, Memorial
Sloan-Kettering Cancer Center, NYC, USA.
The lab develops cutting-edge techniques (Nature,doi:10.1038/ nature09163 (
2010)) aimed at gaining a mechanisti... 阅读全帖 |
|
a*****t 发帖数: 81 | 49 K离子怎么调节神经传导 ? 你说的是synaptic 还是 axonal 传导 ?
我认为注射KCL 能引起心肌细胞去极化失去自动收缩能力, 或者
通过blood brain barrier 使大脑神经元去极化导致中枢紊乱.
消化系统吸收无机盐是用的被动运输方式, 就是说, 当吸收细胞
(主要位于小肠绒毛内的enterocyte)内K浓度过高时它会自动停止
吸收K. K仍旧能渗透只有一种可能性就是吸收细胞破裂, K直接进
入到循环系统, 但是消化系统的血液是先通过kidney 然后才进入
心脏的, kidney里也有 Na, K 离子感受器能排出多余的Na, K.
只有当 kidney 也被破坏以后, K 才能使人致死原因如上. |
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o******6 发帖数: 538 | 50 ☆─────────────────────────────────────☆
qqzj (小车车) 于 (Sat Feb 21 16:40:12 2009) 提到:
发信人: qqzj (小车车), 信区: Programming
标 题: 在ubuntu (linux) 给eclipse下连接R碰到问题。
发信站: BBS 未名空间站 (Sat Feb 21 16:26:32 2009)
我的是ubuntu intrepid ibex and R 2.7. 打算通过StatET plug-in 来用eclipse写和
运行R。
恕我愚昧,我没有办法找到r-base这么一个file。在synaptic package manager 里面
明明是有的。好像在usr/share里面。但是根本找不到。请问这个东西在哪里?(我运
行R挺好的,没有问题。)
另外还有一个小问题。我给eclipse做了一个launcher。一切顺利。但是ubuntu给这个
launcher的icon很不爽。打算换成eclipse 3.4的菱形的icon。可是找到的都是eclipse
3.2这样的圆形 |
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