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全部话题 - 话题: synergism
1 (共1页)
M*****e
发帖数: 279
1
Putting bedbugs to bed forever
Link:
http://www.sciencedaily.com/releases/2014/12/141224103113.htm
On the right side of the this webpage, there are more links about how to
kill bedbugs.
Link to the original paper:
http://onlinelibrary.wiley.com/doi/10.1002/anie.201409890/abstr
Recipe:
Sleep tight! Bed bugs rely on chemical
cues to locate and arrest in safe shelters.
This aggregation pheromone comprises
five volatile components (dimethyl disulfide
and dimethyl trisulfide, (E)-2-hexenal,
(E)-2-oct... 阅读全帖
a****q
发帖数: 100
2
那叫Synergism,呵呵。
所谓亚民念派,卫斯理派都是Synergism旗下的宗派。
R******d
发帖数: 168
3
来自主题: TrustInJesus版 - 神恩独作(monergism)是什么意思?
神恩独作是什么意思?
What does monergism mean?
诚之获授权翻译。
原文载于:http://www.monergism.com/thethreshold/articles/onsite/qna/monergis
m.html
神恩独作(Monergism):在重生时,不是依靠我们未重生的人性与神有任何的合作,而
是圣灵使我们与基督联合。祂藉著外在的呼召,即神的道的宣讲,解除我们内在敌意的
武装,除去我们的瞎眼,照亮我们的心智,使我们明白,把我们的石心变成肉心——使
我们喜爱神的话——以我们被更新的情感,竭尽全力、心甘情愿地拥抱基督。被圣灵所
默示的先知以西结断言:“我要使他们有合一的心,也要将新灵放在他们里面,又从他
们肉体中除掉石心,赐给他们肉心,使他们顺从我的律例,谨守遵行我的典章。他们要
作我的子民,我要作他们的神。”(结11:19-20;另参36:26)。使徒保罗说,“被神
所爱的弟兄啊,我知道你们是蒙拣选的;因为我们的福音传到你们那里,不独在乎言语
,也在乎权能和圣灵,并充足的信心”。(帖前1:4-5)这就是说,在重生时,神的道
不是单独做工的,必须伴... 阅读全帖
g********0
发帖数: 6201
4
来自主题: Biology版 - 造假,这回是老中
Cancer Postdoc on Probation for Falsifying Data
06/05/2012 Jesse Jenkins
A former postdoc at Brigham and Women’s Hospital and Harvard Medical School
who confessed to splicing together Western blots has been put on probation
by the federal government.
A former postdoc at Brigham and Women’s Hospital (BWH) and Harvard Medical
School who deliberately fabricated data in federally funded lung cancer
research has been put on probation by the government.
The postdoc, Jian Ma, fabricated images in a man... 阅读全帖
l***y
发帖数: 4671
5
比如说,有这样一个 hypothesis:两种药的 targets 越不相干,那么这两种药的
synergism 就越好。手头有一两百种药的某几个癌症的 cell line 上的 microarray
数据以及 IC50,那么就要先用图论的工具和几种备选的图模型来两两计算药的相干性
,得出基准分布,进一步算出每对药的组合的大家深恶痛绝的 p-values,然后根据要
使用的统计模型设计抽样方式来保证正交性的同时尽量减少样本量。然后上 384 孔板
,测数据,用事先选的统计模型分析来看哪种图模型最好地符合 hypothesis,同时看
这时 hypothesis 是否靠谱。然后用这种图模型预测最佳和最差的药的组合,重新上
384 板验证。在图上找到最佳组合的关键节点,k/d 或者 inhibit 之,再上 384 板验
证。最后根据经费和信心,要么 in vitro 上病人的细胞,要么 in vivo 在老鼠上种
cell line,再重复一下最佳和最差的药的组合。
做完这个 project 后,把数据给数学家们来做 classification,找出能最好预测
synergism 的图... 阅读全帖
l***y
发帖数: 4671
6
比如说,有这样一个 hypothesis:两种药的 targets 越不相干,那么这两种药的
synergism 就越好。手头有一两百种药的某几个癌症的 cell line 上的 microarray
数据以及 IC50,那么就要先用图论的工具和几种备选的图模型来两两计算药的相干性
,得出基准分布,进一步算出每对药的组合的大家深恶痛绝的 p-values,然后根据要
使用的统计模型设计抽样方式来保证正交性的同时尽量减少样本量。然后上 384 孔板
,测数据,用事先选的统计模型分析来看哪种图模型最好地符合 hypothesis,同时看
这时 hypothesis 是否靠谱。然后用这种图模型预测最佳和最差的药的组合,重新上
384 板验证。在图上找到最佳组合的关键节点,k/d 或者 inhibit 之,再上 384 板验
证。最后根据经费和信心,要么 in vitro 上病人的细胞,要么 in vivo 在老鼠上种
cell line,再重复一下最佳和最差的药的组合。
做完这个 project 后,把数据给数学家们来做 classification,找出能最好预测
synergism 的图... 阅读全帖
C*********y
发帖数: 1424
7
来自主题: _time_management版 - the famous one
The Seven Habits - An Overview
Our character is a collection of our habits, and habits have a powerful role
in our lives. Habits consist of knowledge, skill, and desire. Knowledge
allows us to know what to do, skill gives us the ability to know how to do
it, and desire is the motivation to do it.
The Seven Habits move us through the following stages:
1. Dependence: the paradigm under which we are born, relying upon others
to take care of us.
2. Independence: the paradigm under which we can... 阅读全帖
v*****s
发帖数: 20290
8
http://thediplomat.com/2014/01/chinas-deceptively-weak-and-dang
In April 2003, the Chinese Navy decided to put a large group of its best
submarine talent on the same boat as part of an experiment to synergize its
naval elite. The result? Within hours of leaving port, the Type 035 Ming III
class submarine sank with all hands lost. Never having fully recovered from
this maritime disaster, the People’s Republic of China (PRC) is still the
only permanent member of the United Nations Security Council... 阅读全帖
w****f
发帖数: 5
9
刚从一个大牛的blog上看到的,想存在哪儿备用,觉得存这儿不错,大家可以一起用。
1. Accelerated 35. Empowered 69. Motivated
2. Accomplished 36. Enabled 70. Negotiated
3. Achieved 37. Encouraged 71. Obtained
4. Acted 38. Engineered 72. Operated
5. Adapted 39. Enhanced 73. Orchestrated
6. Administered 40. Enlisted 74. Organized
7. Allocated 41. Established 75. Originated
8. Analyzed 42. Evaluated 76. Overhauled
9. Approved 43. Examined 77. Oversaw
10. Assembled 44. Executed 78. Perfo... 阅读全帖
m**********t
发帖数: 385
10
Organization Description:
Philips Research is the source of many advanced developments in Healthcare,
Lifestyle and Technology. Building on 90 years’ experience in industrial
research and our world-leading patent position, we’re dedicated to
meaningful innovations. In the healthcare domain, we are enhancing imaging
and monitoring systems, as well as exploring innovative personal healthcare.
In lifestyle, we’re helping people see, hear, remember and share content,
anywhere and anytime. Our vision... 阅读全帖
m**********t
发帖数: 385
11
Organization Description:
Philips Research is the source of many advanced developments in Healthcare,
Lifestyle and Technology. Building on 90 years’ experience in industrial
research and our world-leading patent position, we’re dedicated to
meaningful innovations. In the healthcare domain, we are enhancing imaging
and monitoring systems, as well as exploring innovative personal healthcare.
In lifestyle, we’re helping people see, hear, remember and share content,
anywhere and anytime. Our vision... 阅读全帖

发帖数: 1
12
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖
w****l
发帖数: 6122
13
来自主题: Stock版 - 各位大牛,XOM适合long吗?
cvx or bp is better than XOM,b/c they have better exposure in natural gas
than xom. Although xom bought xto, the synerge need some time to show up.
but cvx warn its profit today, we might see some downard of energy stocks t/
w.
w****g
发帖数: 634
14
明天XOM的业绩报告可能会推高股价,因为XOM去年or前年收购了XTO
XTO是美国当时最大的天然气提供商,本身市值都很高,
XOM收购XTO之后,这个synerge应该是蛮大的,看好XOM会涨不少。
v*******n
发帖数: 8995
15
来自主题: Immigration版 - 转让个审稿,tumor biology
好像非常合适我的背景,请考虑一下我, 谢谢
ying wang
[email protected]
/* */
背景是molecular biology,cancer(ovarian cancer, tumor metastasis)/stem cell
biology
文章有molecular cell 和cancer research
1. Wang Y, Arribas-Layton M, Chen Y, Lykke-Andersen J, and Sen GL.DDX6
Orchestrates Mammalian Progenitor Functionthrough the mRNA Degradation and
Translation Pathways. Mol Cell. doi:10.1016/j.molcel.2015.08.014
2. Mistry DS, Chen Y, Wang Y, Sen GL. Transcriptional profiling of SNAI2
regulated genes in primary human kerat... 阅读全帖
n****r
发帖数: 246
16
来自主题: Immigration版 - 攒人品,推荐审稿
title:"No synergism between bis(propyl)-cognitin and rasagiline on
protecting dopaminergic neurons and alleviating motor defects in MPTP-
induced Parkinsonism"
有意者站内联系,只推荐不保证
n****r
发帖数: 246
17
来自主题: Immigration版 - 攒人品,推荐审稿
a paper entitled "No synergism between bis(propyl)-cognitin and rasagiline
on protecting dopaminergic neurons and alleviating motor defects in MPTP-
induced Parkinsonism" for Neural Regeneration Research
i********n
发帖数: 171
18
来自主题: Immigration版 - 审稿
Please send your CV to [email protected]/* */ with selected MS#. 请务必认真审稿并及
时提交意见,谢谢
1. Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat
pulmonary arterial smooth muscle cells
2. Fyn-related kinase expression predicts favorable prognosis in patients
with cervical cancer and suppresses malignant progression by regulating
migration and invasion
3. The Protective effect of Citrus limon essential oil on Hepatotoxicity
and nephrotoxicity induced by aspirin in rats
4. ... 阅读全帖
B********e
发帖数: 19317
19
【 以下文字转载自 WaterWorld 讨论区 】
发信人: ruomu (ruomu), 信区: WaterWorld
标 题: 一个学长天天玩dota 结果GRE接近满分 让你见识下。。。
发信站: BBS 未名空间站 (Fri Apr 1 10:58:57 2011, 美东)
总的来说,DoTA是一个文化包容性很强的游戏,而且DOTA中文版翻译的还是非常非常好
的~~~
(既然这么多人看。。lz顺征人交流魔兽对战,是1v1对战喔)
后文会出现的一些常用缩写:
War3:warcraft 3 魔兽争霸3
RA:red alert 红色警戒系列
SC: star craft 星际争霸
CoD:call of duty 使命召唤
还有一些游戏的名称在文中会有注释。
好了,正文:
关于Dota和一些游戏中的GRE词汇
A字头
Abaddon :DOTA中地狱领主的名字。本意为地狱,恶魔。是圣经里的亚玻伦 (地狱的
使者)。
abomination:war3中的憎恶。abominate痛恨,憎恶。
aegis:immortal aeg... 阅读全帖
x******4
发帖数: 266
20
来自主题: LeisureTime版 - 推荐《高效能人士的七个习惯》
http://www.amazon.com/exec/obidos/ASIN/1451639619/ebookworld02-
史蒂夫柯维的这本《高效能人士的七个习惯》注重讲了在很长的一段时间内作者根据
自身生活工作遇到的各种挫折和收获进而研究出在职场、在生活当中作为一位高效能人
士如何利用自身的优秀习惯进而成为家庭里受子女欢迎老婆(公)疼爱职场里发展步步
向前所向披靡的。
此书很多人都在讲,从商界大佬、精英阶层到秋叶大叔、微信读书推荐,拿到该书
后看到扉页上面各种牛人的推荐语言顿时觉得犹如尚方宝剑在手,随便一出手那也是狠
角色哈。这种管理类封为经典的书,已经走过了20多年,我看的这本属于20年经典版,
前言和后序都添加了作者在上一个版本之后对于该书面世后收到世人的反馈以及自己从
中得到的收获。
开篇明义言简意赅的讲述了高效能人士的七个习惯分别是:
1.积极主动(Be Proactive)
2.以终为始(Begin with the end in mind)
3. 要事第一(Put First thing first)
4. 双赢思维(Think Win/Win)
5. 知彼解己(Se... 阅读全帖
l******a
发帖数: 2273
21
来自主题: LeisureTime版 - 二月读了3本书
1 - Be Proactive
2 - Begin with the End in Mind
3 - Put First Things First
4 - Think Win-Win
5 - Seek First to Understand, Then to be Understood
6 - Synergize
7 - Sharpen the Saw
r***u
发帖数: 1272
22
总的来说,DoTA是一个文化包容性很强的游戏,而且DOTA中文版翻译的还是非常非常好
的~~~
(既然这么多人看。。lz顺征人交流魔兽对战,是1v1对战喔)
后文会出现的一些常用缩写:
War3:warcraft 3 魔兽争霸3
RA:red alert 红色警戒系列
SC: star craft 星际争霸
CoD:call of duty 使命召唤
还有一些游戏的名称在文中会有注释。
好了,正文:
关于Dota和一些游戏中的GRE词汇
A字头
Abaddon :DOTA中地狱领主的名字。本意为地狱,恶魔。是圣经里的亚玻伦 (地狱的
使者)。
abomination:war3中的憎恶。abominate痛恨,憎恶。
aegis:immortal aegis 不朽盾,同时aegis是汉化版的作者。在RA2中也有神盾巡洋
舰 AEGIS Cruiser。
acolyte:侍僧,教士的助手。war3中Undead的农民。
alacrity:blade of alacrity 欢欣之刃。alacrity还有敏捷之意,所以它加敏捷属
性就... 阅读全帖
y***v
发帖数: 270
23
来自主题: WaterWorld版 - 肖传国和肖式反射弧科普文
你们看看: 比较长,
转一篇文章。让事实为肖传国说话
转自:虹桥科教论坛 http://www.rainbowplan.org/bbs/topic.php?topic=114563&select=&forum=1
有人在散仙谷转了一篇文章。应该把这篇文章广为转发。让当局和国内不明真相的人民
都知道肖传国的医学探索的价值。方舟子夹私打假必然会被钉在科学的耻辱柱上。
“肖氏反射弧”真相解析
肖传国教授在世界上第一个提出并证实 “人工建立体神经-内脏神经反射弧” 用于治
疗各种脊髓损伤导致的排尿障碍。这一发现在肖传国与方舟子之间挑起了一场科学与反
科学长达五年的论战。为帮助公众了解这场论战的事实真相,本文首先从学术角度根据
科学文献和科学事实对“肖氏反射弧”作一番解析。
反射是神经支配机体生理机能的基本方式。反射弧一般由感受器,传入神经,反射中枢
,传出神经和效应器组成。正常的排尿反射由位于脑干和大脑皮层的高级排尿中枢控制
达骶髓的排尿反射初级中枢完成。膀胱充盈时,膀胱壁的牵张感受器受到刺激而兴奋。
冲动传入高级中枢产生排尿欲。中枢经过判断认为可以排尿,于是发出神经冲动沿下行
传导束到脊髓初... 阅读全帖
R*o
发帖数: 3781
24
来自主题: TrustInJesus版 - What Love Is This? (6) call upon evangelicals
Under "The Question of Truth,"
We therefore call upon evangelicals to return to the once-held biblical view
. .. that to lay claim to a particular doctrine [Calvinism] as true is not s
piritual arrogance but a biblical duty.
Under ` A Vision for Reformation,"
We therefore call upon evangelicals to affirm a vision for reformation which
is in accordance with the witness of Scripture and in continuity with the h
istoric testimony of the [Calvinist] church. Such a vision is of a church wh
ich is bot... 阅读全帖
C****i
发帖数: 1776
25
第二章 加尔文的神学
此次演讲的题目是加尔文约翰的神学。我要从广义方面来讨论此题,那就是说我不打算
多论到加尔文为第二章神学家的个人特性,乃述说加尔文所教导之神学的决定性格。换
言之,我要说到加尔文主义,就是具有加尔文之名的伟大宗教思想系统(当然加尔文并
非是该思想系统的鼻祖,只不过是其主要阐述者),并其构成的手腕与组织天才所加给
该思想系统之不可磨灭的印象。自从那伟大的宗教改革发轫以来,在所有将心思与意志
贡献给这伟大运动的教师中间,此思想系统是有负于加尔文的,所以从那时到如今,此
思想系统具有加氏之名是当之无愧的。在加氏所有的工作中给于人类的最大贡献,无疑
就是复兴这宗教思想系统,藉其天才之力使之复苏为新的生命,因此他是值得广被纪念
的。当吾人考察加尔文主义之核心时,我们也是探寻加尔文的思想。加尔文主义是他最
伟大与最有意义的纪念碑,只有正当了解加尔文主义的人,才能最理解加尔文。
大约在一百年前,高贝尔(Max Gobel)首先敦请当时学者,把加尔文主义的构成原则作
有系统的研究。虽有很多著名学者会在此项工作上竭尽精力,但吾人敢说,并未收到一
致的效果。因为加尔文主义的原则已被混... 阅读全帖
m****a
发帖数: 9485
26
Is it true that because Latter-day Saints reject the doctrine of salvation
by grace alone, they are not Christians?
Perhaps the most famous statement of the Latter-day Saint understanding of
the relation between grace and works is in 2 Nephi 25:23: “It is by grace
that we are saved, after all we can do.” [2 Ne. 25:23] This idea is
sometimes called synergism—a term Van A. Harvey has used to describe Roman
Catholicism. 23
The doctrine that salvation depends both on God’s grace and man’s good
works... 阅读全帖
l**********t
发帖数: 5754
27
来自主题: TrustInJesus版 - 神恩独作(monergism)是什么意思?
is monergism vs. synergism the main differences between Calvinism and
Arminianism?

,而
G*******s
发帖数: 4956
28
再看看早期教父们的正确和错误的观点
林慈信:早期教会信仰真伪辨——上帝,圣父,圣子﹕我们的信仰
http://blog.sina.com.cn/s/blog_622134fd01013i7w.html
早期教会信仰真伪辨 THE FAITH OF THE EARLY CHURCH
上帝,圣父,圣子:我们的信仰
GOD, THE FATHER, AND THE SON: WHAT WE BELIEVE
1.上帝:一位格,三位格
GOD: ONE, PERSON, PERSONAL, THREE PERSONS
只有一位真神。宇宙并没有两位神(创造主 + 至高至善神:诺斯底主义)。
There is only one God. There aren’t two gods (creator-demiurge, plus the h
ighest God: Gnosticism).
上帝是位格。上帝不只是祂的属性的总和。
God is a person. God is not just a bunch of attributes.
上帝是有位格的。祂在永恒里计划要创造人,与人建立(约的)关... 阅读全帖
n********n
发帖数: 8336
29
来自主题: TrustInJesus版 - 亚米纽斯神学
拣选与预定
亚米纽斯将预定的教义(神指定一些人得救),解释为神的预知。因为神知道谁会
拣选他,而这些人就是神所预定的。他也将预定的教义解释为神知道那些人不单会相信
,而且会坚守信仰。亚米纽斯论到个别信徒所蒙的拣选,他说:「神的旨意是根据神的
预知,即是说神从亘古以前已经知道谁会相信,这是根据他借先前思典,所赐予人的悔
改和信心;神也知道谁会倚靠后来的恩典而坚守信心;谁不会相信,谁不会坚守。」
亚米纽斯的预定论,包括了所有人类;定义如下:「神的旨意是拯救人类脱离全然
败坏的境况。神不是武断和滥纵地,只将救恩赐给一些人。预定的范围包括所有人,但
预定的条件单单就是相信耶稣基督的人。」
亚米纽斯说,人蒙拣选得永生是基于相信基督。这不是出于神武断的抉择,反之,
这是根据人对福音的回应。
先前恩典(Prevenient Grace)
先前思典就是神赐给所有人的一种「预备的」恩典,让人能回应并接受福音。先前
思典可以定义为:「人的灵魂进入救恩大门之前的第一步,或预备的恩典(
preparatory grace)。这是圣灵向在罪中无助的人所施的恩典。对有罪的人,这... 阅读全帖
n********n
发帖数: 8336
30
来自主题: TrustInJesus版 - 亚米纽斯神学
拣选与预定
亚米纽斯将预定的教义(神指定一些人得救),解释为神的预知。因为神知道谁会
拣选他,而这些人就是神所预定的。他也将预定的教义解释为神知道那些人不单会相信
,而且会坚守信仰。亚米纽斯论到个别信徒所蒙的拣选,他说:「神的旨意是根据神的
预知,即是说神从亘古以前已经知道谁会相信,这是根据他借先前思典,所赐予人的悔
改和信心;神也知道谁会倚靠后来的恩典而坚守信心;谁不会相信,谁不会坚守。」
亚米纽斯的预定论,包括了所有人类;定义如下:「神的旨意是拯救人类脱离全然
败坏的境况。神不是武断和滥纵地,只将救恩赐给一些人。预定的范围包括所有人,但
预定的条件单单就是相信耶稣基督的人。」
亚米纽斯说,人蒙拣选得永生是基于相信基督。这不是出于神武断的抉择,反之,
这是根据人对福音的回应。
先前恩典(Prevenient Grace)
先前思典就是神赐给所有人的一种「预备的」恩典,让人能回应并接受福音。先前
思典可以定义为:「人的灵魂进入救恩大门之前的第一步,或预备的恩典(
preparatory grace)。这是圣灵向在罪中无助的人所施的恩典。对有罪的人,这... 阅读全帖
s**u
发帖数: 9035
31
来自主题: Biology版 - 谢博士去miami了啊
He has 12 papers, 3 of which are first-author papers. see below
Differential regulation of androgen receptor by PIM-1 kinases via
phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Linn DE, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li
W, Xu K, Chen M, Qiu Y.
J Biol Chem. 2012 Jun 29;287(27):22959-68. Epub 2012 May 14.
PMID:
22584579
[PubMed - indexed for MEDLINE]
Related citations
2.
A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostat... 阅读全帖
s**u
发帖数: 9035
32
Dr.Xie has 12 papers, 3 of which are first-author papers. see below
Differential regulation of androgen receptor by PIM-1 kinases via
phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Linn DE, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li
W, Xu K, Chen M, Qiu Y.
J Biol Chem. 2012 Jun 29;287(27):22959-68. Epub 2012 May 14.
PMID:
22584579
[PubMed - indexed for MEDLINE]
Related citations
2.
A Role for OCT4 in Tumor Initiation of Drug-Resistant Pro... 阅读全帖
S**********e
发帖数: 1789
33
来自主题: Biology版 - 【想海归求建议】
给你看看我们系刚进来的助理教授
Vanderbilt University School of Medicine
Fingleton, Barbara Mary , Ph.D. Assistant Professor of Cancer Biology
Publications

Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK
, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required
for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Cancer Res, 71(4), 1302-12, 2011.
Koon, HB, Fingleton, B, Lee, JY, Geyer, JT, Cesarman, E, Parise, RA, Egorin,
MJ, Dezube, BJ... 阅读全帖
s****9
发帖数: 932
34
1. 你是synergic,还是allogenic?
2. 你可以适当的减少irradiation 的dosage或者separate成2次irradiation
3. 我做过很多用rag1KO的recipient,没觉得和普通的recipient有太大差异。
s******c
发帖数: 331
35
来自主题: Biology版 - antagonist dose-response curve 求解读
schild regression plot是比较老的方法了,这两个图里做的competition binding
curves是比较现代的用来发表的东西,你为什么要转化?
就这个图来说,B很可能是negative allosteric modulator,因为competition curve
达到的plateau跟你用的agonist有关,说明B不是competitive binding。如果B是
competitive binding,理论上当B达到足够的浓度应该会完全compete掉agonists从而
最后的plateau完全是B的效果,如同A一样,agonist-independent,现在B的
competition curves plateau是agonist-dependent,说明B是non-competitive
binding。
当然,证明一个compound是allosteric ligand是复杂的,一个实验不够,往往需要多
个实验去从各个方面证明。就你贴的这个结果,很多问题,首先agonists应该不是
radioactive的,可能是fluorescen... 阅读全帖
w***r
发帖数: 709
36
来自主题: Biology版 - Immunotherapy from U Penn
挺牛但是长期效果,尤其是复发情况有待观察(个人不太看好,为啥肿瘤一定要有免疫
原性??)
谁知道相关文章推荐一下。
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
(NEJM 2012)
Background: A major implication of the clinical activity of immune
checkpoint blockade is that significant endogenous immune responses to tumor
antigens are generated, and these responses may be harnessed
therapeutically to mediate clinical tumor regression on checkpoint
inhibition. An emerging concept in cancer immunology is that inhibitory
ligands su... 阅读全帖

发帖数: 1
37
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖

发帖数: 1
38
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖

发帖数: 1
39
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖

发帖数: 1
40
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖

发帖数: 1
41
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖

发帖数: 1
42
The Laboratory for Micro-Nano Scale Bio-manipulation, Imaging and Sensing at
Thayer School of Engineering at Dartmouth College, an Ivy League
institution, warmly invites applications for one Research Associate position
. We are looking for rising scholars with great research potential who are
desirous of independent academic or industrial R&D careers.
Our mission is to create knowledge, new concepts, and innovative
technologies at the interfaces of life science and engineering, and to
advance th... 阅读全帖
o******g
发帖数: 133
43
来自主题: _Les_Forum123版 - 灌水只灌纯净水 01
7 Habits of Highly Effective People (by Stephen Covey)
• Habit 1: Be Proactive: Principles of Personal Choice
• Habit 2: Begin with the End in Mind: Principles of Personal
Vision
• Habit 3: Put First Things First: Principles of Integrity &
Execution
• Habit 4: Think Win/Win: Principles of Mutual Benefit
• Habit 5: Seek First to Understand, Then to be Understood:
Principles of Mutual Understanding
• Habit 6: Synergize: Principles of Creative C
l***h
发帖数: 9308
44
来自主题: _voip版 - 今天sipsorcery有问题吗?
http://blog.sipsorcery.com/
Server Migration – 17th June 2012 at 0200 PST
The SIPSorcery server will be moving to a new host in one week on Sunday the
17th of June 2012 at 0200 PST. The move is to take advantage of some synerg
ies with another SIP service, there will be more information on that further
down the track. The consequence of the server move will be that the IP addr
ess of the service will change from 69.59.142.213 to 67.222.131.147. Ideally
all users should be using sipsorcery.com an... 阅读全帖
g****n
发帖数: 3370
45
来自主题: _voip版 - 今天sipsorcery有问题吗?
多谢!上次因为我网络问题换了IP地址,改成域名就行了。;)

the
synerg
further
addr
Ideally
anyone
addre
1 (共1页)