b******y
发帖数: 627 | 1 yes. By convention, your institute(s) and your boss take the majority of it
and you will have a smaller slice, if it eventually goes anywhere. On the
other hand, your institute will patent it on your behave, too. The
application process is tedious and expensive. |
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T****i
发帖数: 15191 | 2 很多苦逼型老板，自己也是刻苦出来的，认为勤奋是科研成功的必要条件。我讨厌的那
个女AP，有一次跟我聊起来，我说创造性是最重要的，她说”No，你不懂的，我最需要
的就是好好用pipette 的人”。其实，她说的是奴工，不是科学家。如果只是要勤奋的
话，科研就成了自虐，还会有意思吗？
到底勤奋重要吗？重要，也不重要。科研就像练葵花宝典，勤奋就像自宫。当有人告诉
你，欲练神功，必先自宫。那你得好好想想。因为的确有不少例子，说明即使自宫，未
必成功；甚至不用自宫也能成功。当你听老板的话，无比勤奋地投入，最后只能换来心
酸血泪时，你会后悔的。我不相信什么“至少自己拼了全力，不后悔”之类的crap。如
果一个人总是很勤奋，又总是不成功，那得好好反思以下自己的方法甚至自己的
philosophy是否正确。同样，一个老板，整天盯着手下的人，要求勤奋工作，但手下的
人就是不怎么出好结果，那她是不是也得反思以下？可悲的是，很多老板在这个时候，
却不是坐下来好好想想，而是变本加厉push，进入恶性循环。
我以为，科研最重要的是选题（眼光），其次是创造性（方法），再次才是勤奋。没有
前两项，勤奋没有意义，因为... 阅读全帖 |
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s******y
发帖数: 220 | 3 我管的line很多，老板也没经验，（我们lab以前做大型动物model的）我phd做生化的
，老鼠对我来说也是新的，我一开始genotyping都是自己做的，我们triple mutant做
起来也很tedious的。而且还有别的line等着我。估计有些一直做老鼠的lab都有专门的
technician来干这些吧，而且人家更有经验知道这些隐患。
后来反正也发现了现象，就一直拖着：（，因为我要做很多别的实验来characterize啊
，一忙又忘了。
再说吧，我要back cross回去，就算5代，一代三个月，那也要15个月后开始
characterize了，觉得耗时太久了。
什么叫每代跟每代老鼠不一样？ 我的确发现有variation，我平行设了几个breeder，
来自于各个breeder的老鼠，on average 没有明显不同，但是 littermate的确有
variation， 有的发病快，有的发病慢。 |
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e*******o
发帖数: 4654 | 4 In theory, it is not.
In practice, as you said, most people's life is wasted on tedious bench work.
So, love yourself and stay away from it.
the |
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g******r
发帖数: 139 | 5 OK,what you mean is the cDNA concentration used should be in the linear
region of the reaction.
This concentration would vary for each of the genes, dependent on the
abundance. I did not perform such cDNA dilution pilot experiment for each
gene. I just used 2-4 ng cDNA in the real-time PCR. One would assume the
gene with Ct of 25-31 is within the linear range, if the Ct is >33, it is
possible the cDNA conc is kind of out the range.
And it is true as Isaid that I got no outlier replicates for gen... 阅读全帖 |
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f*******e
发帖数: 628 | 6 Apparently work/life balance is more important to some people than money.
I would rather live a minimal lifestyle than hold on to a tedious job just
for money. |
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m***T
发帖数: 11058 | 7 这个现在看来很有可能。ilmn的技术最成熟，市场做得也最好，而且它也在发展自己的
nanopore。除了ont以外，还有多家在用nanopore发展的。pacbio因为成本问题机器很
难用于一线临床，只能在研究领域拼一拼。现在据说也在发展便携式的，具体到什么地
步了还不知道。solid已经停止发展了，所以基本上已经退出这块市场了，ion虽然
homopolymer的问题不大可能从现有技术上得到根本上的改善，但随着chemistry和更有
针对性的algorithm，现在的准确度还算不错。它的优势一是sample需要很低的起始量
，二是cancer hotspot panel等其它及个panel的效果在临床实验的观察来看feedback
比较positive，所以在临床论断市场还有些竞争力。如果它能彻底把tedious的epcr给
弃掉，会更有竞争力的。roche刚买了另一个以nanopore为技术的公司genia http://www.geniachip.com/，所以后面如何还不太清楚。genia的技术是在solid state上面不象目前的ont是engineering pro... 阅读全帖 |
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c********r
发帖数: 1125 | 8 Mom tried hard to teach us Chinese after school, but as I got older I found
these lessons increasingly tedious. I well understood spoken Chinese at a
child's level (e.g. the Chinese for "Tidy your room!" is permanently etched
into my brain) but was reluctant to speak it myself, due to the wish (all
too common among children of immigrants) to distance myself from my parents'
accents and intense pride in their ethnicity and traditions. Likewise they
despaired over my refusal (like a "foreign devil... 阅读全帖 |
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s********d
发帖数: 103 | 9 I guess, it is GMP or QA area. It is tedious work but reliable job. It is a
job not a career. So what? we need a job to survie and a career to thrive.
suriving always goes first. It is possible to move to the regulatory rease
with your backgorund, and it is more challenging and higher paid.Good luck
and be happy! Many of your fellowers envy you. |
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i***r
发帖数: 1035 | 10 bioinfor is pretty good in my opinion.
pay is good compared to most others. most bioinfor people i know having 80k-
150k salary (~5 years experiences post phd).
and work is interesting.
CS might get higher pay, but job like software engineer is more tedious (in
my opinion ONLY) unless you really love coding/debugging.
You can be a good bioinformatician regardless your background.
CS people can do more algorithms
BIO people can do more discovery
STATS people can do more analysis
and bioinformatic... 阅读全帖 |
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x********4
发帖数: 405 | 11 pursuing a phd is a significant commitment. you have to be clear about if
you are interested in doing research, i.e., discover something about
accounting or business that nobody know yet, and do sometimes very tedious
things...
if you can get into top accouting phd programs, i guess the starting
slalaries for a fresh phd in accounting in 5-6 years would be 150k+ |
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x******9
发帖数: 47 | 12 工作快5年了，一直在会计事务所，做的是Hedge fund/PE tax. 之前在东部，一进去就
被分在这个组，也没的选，一干就是三年多。干得有些腻了也倦了，想换个税种干干。
于是在corporate tax和 international tax两个offer之间选择了corporate tax，当
时真的是很想再学点东西，也不怕再从头干起，想着international tax的根本还是
corp tax，而且corp tax 做好了什么时候想换internationtal tax都可以。
于是换了个office，也从东岸来到了西岸，想着改行做corp tax。也不知道是运气不好
还是在以前的部门太舒服了，这个corp tax做得非常郁闷，感觉budget比金融税要紧多
了，一样的compliance,也一样的繁琐，或者说更tedious. 又是estimate,又是
underpayment penalty，花了n多时间在研究系统的应用上，也因为给我的staff非常不
得力，渐渐感到这corp tax和想象中的差距挺大的。估计是命中注定，之前合作的PAR
和同事也都过来这个offi... 阅读全帖 |
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s*****l
发帖数: 1844 | 13 Analytical scientists, unfortunately, have limted developmental space, no
matter in discovery or development. If you are a foreigner with a MS degree
, I would say R&D is better for your career development than a QC position.
QC chemists usually get low pay, and do tedious and routine work. Basically
no development if you can not eventually become a supervisor or manager.
But this is usually tough for Chinese due to language and culture challenges
. In R&D environment, if you are smart and hard... 阅读全帖 |
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s*******h
发帖数: 3731 | 14 【 以下文字转载自 PhotoGear 讨论区 】
发信人: skydive (跳跳~~修竹凝妆，垂杨驻马), 信区: PhotoGear
标 题: 勤奋在科研中究竟有多大作用？(本年度在本坛最后一坑） (转载)
发信站: BBS 未名空间站 (Tue Dec 20 13:29:49 2011, 美东)
发信人: Tianzi (tt), 信区: Biology
标 题: 勤奋在科研中究竟有多大作用？(本年度在本坛最后一坑）
发信站: BBS 未名空间站 (Sun Dec 18 22:24:36 2011, 美东)
很多苦逼型老板，自己也是刻苦出来的，认为勤奋是科研成功的必要条件。我讨厌的那
个女AP，有一次跟我聊起来，我说创造性是最重要的，她说”No，你不懂的，我最需要
的就是好好用pipette 的人”。其实，她说的是奴工，不是科学家。如果只是要勤奋的
话，科研就成了自虐，还会有意思吗？
到底勤奋重要吗？重要，也不重要。科研就像练葵花宝典，勤奋就像自宫。当有人告诉
你，欲练神功，必先自宫。那你得好好想想。因为的确有不少例子，说明即使自宫，未
必成功；甚至不用自宫也能成功。当你听... 阅读全帖 |
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h*****s
发帖数: 153 | 15 Synthesis is the most tedious thing in chemistry, in my mind! |
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s*****l
发帖数: 1844 | 16 Really? Some analytical testings are also very tedious! |
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h*****s
发帖数: 153 | 17 Think the first one is more interesting. Molecular biology is very boring
and the experiment is super tedious. |
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o****l
发帖数: 21 | 18 Assume you have n interpolation points xi(i=1,2,3,....n)(n known f(xi)),
you divide the whole domain into many subdomain and each subdomain is defined
by two successive stationary points(the local maximum and minimum points).
Then you use Gaussian quadrature in each subdomain. Since all of this
can be done by computer, you do not need to worry about the tedious work.
As we know, m degree Gaussian quadrature gives us 2m-1 degree approximation.
So you can get your error estimation by defining it |
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j**u
发帖数: 6059 | 19 My question can be expressed in another way. When imagesc(im) is used, a 3D
rgb matrix may be generated to plot a color image. How to get this 3D matrix
? I was thinking of setting up a color mapping table to generate it by mysel
f, but it is tedious. Is there any easier way?
highligh
sol |
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b*********h
发帖数: 46 | 20 和我差不多，作为工程博士，没学会编程实在是很尴尬。我现在在看一个tutorial，很
简单
http://www.cplusplus.com/doc/tutorial/
大概看了一个星期，看了一大半左右，很慢了。例子都比较简单抽象，没什么背景要求。
原来看过一本超厚的，感觉及其tedious，比较适合慢慢的好好的学，所以很快放弃了。
我想如果不打算做很理论的东西，编程可能是非过不可的一关吧，不过慢慢来总会好的
我用了这么多年matlab，还是有大量东西不会，但是知道到哪里去查，我想c++也一样
吧，
入了门就不会再两眼一抹黑。 |
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t****g
发帖数: 715 | 21 My two cents:
(1) why not rewrite the model as y=ac*m+ad*n+bz? If you can do so, then
estimate ac directly and derive its variance afterwards;
(2) if rewriting the model is forbidden for some reason I can not see here,
then note that:estimator of a is normally distributed, as well as estimator of c, and their correlation can be consequently derived,
(2.1) apply delta method to get variance of ac, check your 1st year lecture notes if you forget what delta method is;
(2.2)a tedious way, but it may |
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l*****n
发帖数: 1034 | 22 You might wanna try applying for a teaching job directly, with a J-1 visa.
In schools with a high demand, they hire international teachers with a
teaching certificate and experience from their own countries.
ESL/ELL is a great major, but the job market could be narrow if you don't
have a green card. Special Educatiom, oh well, is always hot, but you have
to have a big heart and patience--not only for the kids, but also for the
tedious paperwork. Math Education wouldn't be too hard, in fact, beca |
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a*****g
发帖数: 19398 | 23 The common-core math standards require that students learn the standard
algorithm for multi-digit adding and subtracting—you know, the process in
which you line the numbers up vertically to add or subtract and regroup as
needed—by the end of 4th grade.
But waiting until then to teach the algorithm is a big waste of time for
some students, writes Tom Loveless, a senior fellow at the Brookings
Institution.
Students begin learning to add and subtract in 1st grade under the common
standards. So teac... 阅读全帖 |
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j**u
发帖数: 6059 | 24 My question can be expressed in another way. When imagesc(im) is used, a 3D
rgb matrix may be generated to plot a color image. How to get this 3D matrix
? I was thinking of setting up a color mapping table to generate it by mysel
f, but it is tedious. Is there any easier way?
highligh
sol |
|
l***g
发帖数: 1035 | 25 any recommendation for the high power (kw) magnetics design sw? i can do by
hand but it's too tedious.. |
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G******k
发帖数: 13 | 26 Everyone seemed to be concerned about whether or not one's BE degree from
China is determined equivalent to an ABET degree.
I understand it is a tedious and painful process to prepare all the required
documents for the foreign degree evaluation. And when everything said and
done, the BE from China is most likely found nonequivalent anyway.
So what is more important actually is how the state PE board looks at the
evaluation results. I tend to think that most state PE boards will still
only requ |
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a*****a
发帖数: 1038 | 27 My 2 cents: You will see quite a few Chinese in any city or town here.
Compared to China, the life style here is simple and tedious.
It will be very very difficult to look after your parents after you go
abroad.
China does not welcome the overseas returnees w/o solid experience. However
, when you retain a certain number of years experience, you will find it is
still difficult to find your place in China. |
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O*****g
发帖数: 1257 | 28 Prestigious firm. Strong in litigation, was AmLaw litigation department of
the year last year.
Interviewed with them last summer. The two junior associates whom I met both
looked like sh*t. And I can tell they didn't like their job. Most likely
they didn't have chances to work on the mega cases, but were stuck in doc
review, or things of that tedious nature. One associate hinted that he was
going to leave the firm. Just did a search. He is not there anymore. |
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c**d
发帖数: 3888 | 29 如果去的法学院不是 Top-14，甚至不是 Top 50，没有很强的 patent 背景，希望你们
能避免弯路。下面的故事读起来像小说，但是我可以告诉你们，非常现实。
http://www.autoadmit.com/thread.php?thread_id=1905801&forum_id=2#20761498
In a couple short weeks, a new wave of hapless lemmings will crack open the
shrinkwrap on those heinously overpriced casebooks, boot up their laptops
for some heated note-taking, and commence their voyage down the road of
America’s most overrated, miserable, and saturated industry: the practice
of law. A pompous, overpaid professor will sau... 阅读全帖 |
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z***x
发帖数: 9 | 30 来自主题: Macromolecules版 - talk-4 Chain Walking produces Branches.
Zhibin Guan, Dupont CR&D,
Science, 283, 2059, 1999
a palladium-diimine catalyst catalyze ethylene polymerization.
利用late transition metal的b-elimination, hydride addition 实现chain walking
process.
通过调节气压改变的chain-walking 和polymer chain propagation
的速度从而实现tuning
polyethylene topology with pressure which can form linear PE to Dendritic PE.
It is very promising to make dendrimer by simple conventional polymerizaiton
method instead of tedious multi-step synthesis. |
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p*****x
发帖数: 68 | 31 i made some polymer which is soluble in DMF and monomers are soluble in CH3CN,
so i tried to precipitate from CH3CN, but it seems to lose quite some material
in that process. can i decrease the loss by using more CH3CN?
i also tried to wash with CH3CN and filter, then dissolve the polymer off the
filter and pump off DMF, but since DMF is quite high boiling, it is quite
tedious.
any suggestions? |
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a***u
发帖数: 9 | 32 You can try distilling some DMF from the polymer solution under vacuum. If the
solution is too dilute, you may have fine powders which are extremely
diffucult to collect unless you use a very good centrifuge. Yes, getting rid
of DMF is tedious. But spending even an hour on that may save you many hours
in trying to recover the polymer. Also pouring CH3CN into DMF may give you
different result from pouring DMF into CH3CN, although I am not sure which way
is better for your experiment. In one word, |
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w***a
发帖数: 534 | 33 For cryo TEM, you need special device to plunge your grid into liquid ehtane
to make the sample. I don't know what's the 冷台 referring to but you need
cryo sample holder (which has a small liquid nitrigen dewar)and you also
need something to transfer your grid. It's a tedious job to do Cryo TEM. |
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S*********N
发帖数: 6151 | 34
I just feel that existing proof is too tedious,
lack of the beauty.
I am peasant though, hahaha. |
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l******3
发帖数: 6 | 35 Guess your question is to solve
minimize f(D) over all D with eigenvalues equal to b1, b2,...bn.
Seems not a trivial problem.
You may try out the following method:
Let D0=diag[b1, b2,...,bn]. Your problem can then be rewritten as
minimize norm (R^T*D0*R*A*R^T*D0*R - a* Id) over all real number a,
rotation matrix R, where Id is the identity matrix and R^T is the transpose.
Then you may try to use the usual first-order condition...
The algebraic calculations are tedious but worth trying if this i |
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a***n
发帖数: 3633 | 36 Thanks! I also made a counter example to disprove the argument soon I post
it. But my example is way too tedious than yours. |
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O****y
发帖数: 79 | 37 【 以下文字转载自 Physician 俱乐部 】
发信人: Oldray (麦地.prajnaparamitahrdayasutra), 信区: Physician
标 题: Last dark report's webinar about pathology fellowship application
发信站: BBS 未名空间站 (Tue May 10 10:25:23 2011, 美东)
The Essential Guide to Achieving the Perfect Pathology Fellowship:
Useful Advice and “Must-Do’s” for First-, Second- and Third-Year
Residents
The Dark Report
4/28/11
Justin Clark
Hello, everyone, I’d like to welcome you to the latest Dark Report’s new
PREP webinar series. The Pathology Resident Ed... 阅读全帖 |
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P****4
发帖数: 831 | 38 需要配溶液哈，我们很多样品都需要溶在有机溶剂里。HPLC的流动相acetonitrile毒性
也不小。有时还得做tedious的liquid-liquid extraction
谢谢建议，跟其他组的人接触太多了，自己老板会不会有意见哈？
searching |
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z******n
发帖数: 97 | 39 The increase of new drug approval by FDA was determined by its change of
director, not technology. Drug discovery is still an extremely costly and
tedious process, because the low hanging fruits had been picked. |
|
z******n
发帖数: 97 | 40 The increase of new drug approval by FDA was determined by its change of
director, not technology. Drug discovery is still an extremely costly and
tedious process, because the low hanging fruits had been picked. |
|
b********0
发帖数: 13 | 41 Baxter and BBraun are getting a huge profit from Made in China heparin. Even
Sanofi-Aventis is having a good deal by degrading China heparin to Lovenox
and making over 1b each year. They are well aware of taking advantage of
China heparin. However, when medical issues emerge like this one, to avoid
tedious law process, such as Vioxx with Merck, they have to find someone to
blame for and pull their own feet out of mud. Unfortunately, this time is
China. |
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e**********n
发帖数: 359 | 42 It looks quite tedious to me. Can any one post a tutorial or demo? I'm using
textshop on Mac. |
|
r*****t
发帖数: 286 | 43 ☆─────────────────────────────────────☆
onedrunk (一醉) 于 (Fri Feb 2 12:38:53 2007) 提到:
HM问了这个问题，打的很不好。高手给点看法吧！
谢谢
☆─────────────────────────────────────☆
StarVenus (参商*美洲河岸治安联防) 于 (Fri Feb 2 13:34:30 2007) 提到:
just tell them no, you don't think the job you are going to take is boring.
if it were, you would not take it at the beginning.
☆─────────────────────────────────────☆
onedrunk (一醉) 于 (Fri Feb 2 14:29:16 2007) 提到:
It is task, not job. In any job, tedious task is unavoidab |
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B*********h
发帖数: 800 | 44 ☆─────────────────────────────────────☆
Trustee (trustee) 于 (Sun Apr 29 14:34:47 2007) 提到:
I have been working in a big IB for almost four months, this is my first job
. What I am doing so far is coding GUI, very tedious, it has nothing to do
with my background (math PhD),郁闷啊.
☆─────────────────────────────────────☆
ironny (静水流深) 于 (Sun Apr 29 14:45:53 2007) 提到:
this is very useful information to share.
seems reality is never as sweet as dream.
job
☆─────────────────────────────────── |
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K*****Y
发帖数: 629 | 45 回信不知道为什么不能粘贴附件 ... anyway, tedious but straightforward
derivation. |
|
l******n
发帖数: 9344 | 46 it is a integral
for n=2, it is .75
higher dimension may be tedious |
|
b***k
发帖数: 2673 | 47 ☆─────────────────────────────────────☆
whatever1234 (哈哈) 于 (Sun Jun 22 01:54:24 2008) 提到:
Let X and Y be two gaussian random variables N(0, ) and N(0, ). X and
Y are correlated with a correlation .
What is the law of E (X − Y |2X + Y )
If we calculate the mean and variance of E(x-y|2x+y), it seems too tedious.
Any better ideas? 大牛
☆─────────────────────────────────────☆
bladehaze (^_^) 于 (Sun Jun 22 10:23:41 2008) 提到:
2 normal distribution with correlation, there is a formular |
|
z****u
发帖数: 185 | 48 yes if you assume the stock level moves continuously and does not jump.
not too complicated, but tedious to show. |
|
b***k
发帖数: 2673 | 49 ☆─────────────────────────────────────☆
JackSheng (重新振作) 于 (Fri Jun 19 00:09:32 2009, 美东) 提到:
I have been trying to post my interview experience, but found it quite tedious to write down the procedure in one post, so I would rather put down the questions individually in posts. Here is one from an "investment bank". Well, you guess which one i
You are asked to store a symmetric matrix of, say integers, efficiently. All you know about the matrix is that it is symmetric. Please write me a func |
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t*******e
发帖数: 172 | 50 I am doubt about that
there is an example tell us, X, Y are not independenet N(0,1) with
correlation 0.
If your statement is true, then correlation 0 => independent? Since you
assume there are jointly normal which correlation 0=>independent.
The example is on Page 82 of Shreve's volume 2.
If jointly normal, nothing difficult about calculus, just P(X<=a,Y<=a), and
then take derivate of a, you do not need do tedious calculus. |
|
