b*****s
发帖数: 67 | 1 估计很长,自觉点先给个摘要:
青春期开始头疼.医生说是典型偏头疼.
在国内吃去疼片(阿司匹林),中药(天麻之类的),一直时好时坏.
26岁开始加剧,看美国家庭医生,说是轻微抑郁了.
我不信,看神经科医生,开了topamax,吃的挺好,大大减轻.
一年后拔了智齿,神奇发现不疼了.停了topamax,俩月后复发.
复发严重,巨疼之下拍了片子,又换了医生,诊断为: 鼻窦炎!
现在吃抗过敏药(claritin D),居然就治好了!
下面是比较细节的经历,我发现偏头疼得的人还多的,希望我的经历对一些朋友有一点帮
助.
一开始头疼不算很严重,大概一个月俩三次左右,厉害的时候会想吐.吃阿司匹林会好.上
了大学之后由于不会保养,瘦了好多,头疼加剧了些.也没治好.
毕业之后出国,也没见头疼有什么变化.只是头疼这个病很讨厌,发作起来会影响工作.此
时总结了些头疼发作的诱因:最怕中午睡午觉,午觉过长,盖的被子过厚,醒后会昏沉加全
身发热,然后就会头疼.所以尽量避免了午睡.还有就是湿着头发睡觉,或者是睡觉着凉也
会头疼.
26岁时工作学习比较忙,作息不太规律.头疼发作时止疼片也不管用了,而且会持续好几
天.受... 阅读全帖 |
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A*******s
发帖数: 9638 | 2 来自主题: Medicalpractice版 - 安慰剂的效果 I hope you read my thread more carefully then jump on your conclusion.
How much do you know Topamax? How many patients do you personally treat
with topamax? I tell you I use Topamax a lot, far more than you can imagine
. Do I get anything from J&J? Nil
Do not underestimate physician's moral standard including your collegues.
There are a lot of good doctors there and you can not just judge them based
on your imagination. There are some dirty deals but they will get caught or
how do you know th... 阅读全帖 |
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A*******s
发帖数: 9638 | 3 来自主题: Medicalpractice版 - 安慰剂的效果 I would worry about your attitude rather than sunshine law if I were your PD
, seriously.
Do you know why only Depakote and topamax are only two AEDs used for
migraines although there are so many AEDs? Do you know Topamax is generic
now and more and more physicians are writing it? Do you know Topamax now is
used for weight loss?
My advice for you is to listen, listen and listen, it's not the time for you
to talk like that.
in
of |
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S***a
发帖数: 1072 | 5 【 以下文字转载自 Stock 讨论区 】
发信人: pentip (I'm looking for one.), 信区: Stock
标 题: 贡献两个biotech的股票吧
发信站: BBS 未名空间站 (Thu Jul 25 13:55:26 2013, 美东)
1. SUPN
FDA 的 tentative approval拿到了。等JNJ的一个药(Topamax)的针对儿童的patent
exclusivity 过期后，“suppose”就可以拿到正式的FDA approval。其实Topamax在6
月23日就已经过期了。
http://ir.supernus.com/releasedetail.cfm?ReleaseID=770220
这个股票目前正在冲高。
2. RMTI
RMTI在板上有过讨论。主要药物是SFP（一种可溶性铁试剂），肾脏透析的病人补血效
果比另外一种现在使用的铁试剂效果好，副作用小，成本要低。两个设计完全等同的三
期临床实验（CRUISE－1和CRUISE－2）中的CRUISE－1在7月中旬已经成功结束，主要的
几个目标（endpoints）都成功了... 阅读全帖 |
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w*******d
发帖数: 3714 | 6 UPDATE 1-Vivus shares fall on regulatory concerns
Tue Jun 15, 2010 3:10pm EDTStocks
* Jefferies: FDA likely to focus on cardiovascular risk
* Lazard downgrades shares to "hold" from "buy"
* Qnexa FDA panel follows Avandia panel
* Shares down 8 pct in afternoon (Adds analyst comment, company comment,
updates stock price)
By Deena Beasley
LOS ANGELES, June 15 (Reuters) - Shares of Vivus Inc (VVUS.O) fell as much
as 9 percent on Tuesday after analysts raised questions about how U.S.
regulators wil... 阅读全帖 |
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b*****d
发帖数: 61690 | 7 强生全球51次召回事件48次将中国排除遭质疑
2013年06月08日 23:22 人民网-健康时报 我有话说(320人参与)
健康时报记者 赵广泉
提起强生，许多人都不会感到陌生。这家1886年成立于美国，迄今已有127年历史
的世界医药巨头，已在全球57个国家建立了250多家分公司，产品和服务遍布全球175个
国家和地区。
强生产品涉及医药、保健、医疗诊断、医药器械和个人护理产品、消费品等十几个
领域。旗下有泰诺、邦迪、美林、仙特明、维思通、吗丁啉、达克宁、采乐、露得清、
可伶可俐、李施德林漱口水等几十个知名品牌。2012年，强生以 650亿美元的经营业绩
，在世界500强企业中位居第138位。
然而令人惊讶的是，2005年以来，这家以“因爱而生”奉为立业之基的全球知名品
牌，世界500强企业旗下，至少13家子公司及其至少27种药品医疗器械、护肤用品等，
或因质量瑕疵或因安全隐患发生了至少51次产品召回事件。
更令人惊讶的是，在强生此起彼伏的这51次召回事件中，竟然有48次将中国列为不
召回之列。
■2008年8月，强生旗下麦克尼尔公司在确认产品存在瑕疵后，雇佣私人承包商秘
密从... 阅读全帖 |
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b*****s
发帖数: 67 | 8 我也是产后偏头痛严重了,后来看了神经科,吃了药,叫topamax,现在控制住了,医生是个
中国人,但他说根据他所知,没有中药能根治这个偏头痛. |
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w*******d
发帖数: 3714 | 9 Arena's drug, lorcaserin, works in a similar way to fenfluramine, but
appears to be safer. One trial of lorcaserin showed that patients who took
the drug twice a day for a year lost, on average, 5.9 percent of their body
weight, compared with 2.8 percent for those taking a placebo.
Vivus' drug, Qnexa, combines relatively low doses of phentermine with the
epilepsy drug topiramate, sold under the brand name Topamax. One late-stage
trial showed that patients who took Qnexa lost an average of 14.7 p |
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y**w
发帖数: 516 | 10 Vivus Inc.'s weight-loss pill Qnexa won the backing of a U.S. advisory panel
as the company seeks to gain approval for the first new obesity drug in 13
years. The shares doubled in late trading.
Advisers to the Food and Drug Administration voted 20-2 today that Qnexa's
benefits outweigh its risks at a meeting at agency headquarters in Silver
Spring, Maryland. The FDA isn't required to follow the panel's
recommendation. The agency is due to decide on the drug, which it rejected
in 2010, by April ... 阅读全帖 |
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A*******s
发帖数: 9638 | 11 dilantin的pharmacology是usmle常考的， 也是attending们最爱问的。 lol
我觉得就两种情况：
1. Pharmacy mistake
2. 病人自己吃药
现在两者都不承认。
药物interaction我就不知道了， 入院后停了Prevacid， 加了topamax。
The
standard
in
Urinary |
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A*******s
发帖数: 9638 | 12 I like your interest, not your explanations.:)
do
Suppose
control
topamax,
had |
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k********n
发帖数: 756 | 13 来自主题: Medicalpractice版 - 安慰剂的效果 Placebo has its scientific basis. It has a little to do with patient's
confidence on his physicians and nothing to do with the sunshine act. The
sunshine act is absolutely necessary because money taint medical practice.
Please read Dr. David Franklin vs Pfizer case
Please read the response from Pharmaceutics, the PHRAMA
Please read how money can buy influence "the wrong war" in the Journal of
Headache, http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4610.2005.05082_5.x/full
If your headache do... 阅读全帖 |
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k********n
发帖数: 756 | 14 来自主题: Medicalpractice版 - 安慰剂的效果 Nobody is judging you, don't get defensive. By the way, national health
bureau in China is refusing implementing laws because they believed in
moral education and standard. Also, headache is treated with vasoactive
herbals and neuro-nutritional supplements for many years on numerous patient
you could imagine.
Anyway, what you said did not provide any evidence to support your
conclusion or reject my conclusion. I feel that you were just showing off or
pea cocking. If it was so, you should go and... 阅读全帖 |
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A*******s
发帖数: 9638 | 15 来自主题: Medicalpractice版 - 安慰剂的效果 Thank you for judging me to be defensive and showing off. Are you so
amnestic?
If you have not used any topamax before, please just simply shut up. |
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k********n
发帖数: 756 | 16 来自主题: Medicalpractice版 - 安慰剂的效果 The sources: personal involvement with the Big Pharma, the headache
specialist who refused speaking at the national meeting, from the gossips in
the headache conference, from the study I conducted, NOT from the number of
pill I prescribed. Also, my colleagues and chairman would seriously doubt
my competency and decision making if I had prescribed Topamax to "many
patients they could not imagine".
All physicians should support the Sunshine Act. It is the personal,
professional, and social respons... 阅读全帖 |
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L******i
发帖数: 124 | 17 Is she taking any medication like Topamax (topiramate)? What's her
intraocular pressure? Sounds like the side effect of this medication: acute
myopia with secondary angle closure glaucoma. It can accompany pupil
dilation and lens displacement. |
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a**e
发帖数: 5094 | 18 我曾经听到一个在Kaiser干神经科的医生说，偏头痛Topamax都不让开，计算机直接就
输不进医嘱。我当时就想，我肯定不会去Kaiser干，治个头疼还要管我。又不是上
chemo |
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l***x
发帖数: 631 | 19 看了你们的帖子，忽然想起三成语：井底之蛙，鼠目寸光，对牛弹琴。估计你们天天忙
着赚钱，也没时间看新闻了。
A大，有emailservice的已经不只Kaiser一家了。并且已经好多年了。自己去打听打听
吧。下载一个kaiser的app，看看里面有什么不就完了。您不是版主吗？能与时俱进一
回吗？感觉您是真不明白什么叫managed care. 好好学学吧。
Acne，没人对你买什么保险有兴趣。只是想让你了解一下外面的世界。你了解的Kaiser
都是什么年代的事r？还谈什么topamax，胰岛素，我都替你不好意思了。好歹都是CMG
。人都用windows8了，您还在抱怨Dos怎么怎么不好用！
原帖所列的这些服务，只有managed care model才能做到. Fee for service 永远不可
能。所以你们不理解。我说的也费劲。
其实要不是二位的傲慢，我也不会对你们不客气。什么你是卖保险的，什么你practice
几年了. 懂礼貌吗？
就此打住不提了 |
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y*****l
发帖数: 5997 | 20 盘前到8块了？！
FDA Rejects Vivus Inc.'s Obesity Drug Qnexa
Thursday 10/28/2010 9:18 PM ET - Dow Jones News
Related Companies
Symbol Last %Chg
ARNA 1.59 0.00%
VVUS 6.13 0.00%
As of 4:00 PM ET 10/28/10
By Jennifer Corbett Dooren
Of DOW JONES NEWSWIRES
WASHINGTON (Dow Jones)--The Food and Drug Administration rejected Vivus Inc.
's (VVUS) obesity drug Qnexa, the company said Thursday.
The rejection marks the second time in less than a week that the agency has
refused to sign off on... 阅读全帖 |
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