h**********r
发帖数: 671 | 1 Thank you so much!!!
Baozi has been sent. |
|
s****9
发帖数: 932 | 2 不知道为什么，学校没有access
http://www.ncbi.nlm.nih.gov/pubmed/22186896
Nat Commun. 2011 Dec 20;2:600. doi: 10.1038/ncomms1609.
A role for T-bet-mediated tumour immune surveillance in anti-IL-17A
treatment of lung cancer.
Reppert S, Boross I, Koslowski M, Türeci Ö, Koch S, Lehr HA, Finotto S.
Source
Department of Anesthesia, Laboratories of Cellular and Molecular Lung
Immunology, Institute of Molecular Pneumology, Friedrich-Alexander-Universit
ät Erlangen-Nürnberg, Hartmannstraße 14, Erlang... 阅读全帖 |
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l**********1
发帖数: 5204 | 3 Sure
please go to
HTTPS//www.rocq.inria.fr/bang/research.html
>
Research topics of the BANG project, briefly reviewed:
partial differential equations, ordinary differential equations,
methods of statistical physics, numerical algorithms and applications to:
Cell division cycle modelling for healthy and cancer cells
Aggregation-fragmentation models for prion and Alzheimer's diseases (ANR TOPPAZ)
Cell chemotaxis and cell aggregation (in French)
Molecular cancer pharmacotherapy and its optimisation... 阅读全帖 |
|
T**7
发帖数: 264 | 4 International Journal of Oncology
November 2009
Volume 35 Number 5
Regulation of protein tyrosine kinases in tumour cells by the
transcription factor Ets-1
Authors: Jens Claus Hahne, Sebastian Kummer, Lukas Carl Heukamp, Tanja Fuchs
, Marina Gun, Berit
Langer, Alexander Von Ruecker, Nicolas Wernert
Affiliations: Institute of Pathology, University of Bonn, 53011 Bonn,
Germany
Doi: 10.3892/ijo_00000413
Pages: 989-996
感激不尽 |
|
b**********8
发帖数: 349 | 5 做了一批tissue microarray，检测某个protein在癌组织和癌旁组织中的表达。统计学
分析发现癌旁组织中（注意不是癌组织）该protein的表达和multiple tumour，
microvascular invasion以及overal survival显著相关。该怎么解释这个结果？接下
来可以做哪些工作继续深入研究？
欢迎大家讨论并提出宝贵意见和建议，谢谢。 |
|
l**********1
发帖数: 5204 | 6 Cell 2012 may 同一期
三姐/妹 印度裔英国人 Serena Nik-Zainal
Supervisor: Mike Stratton
Exploring the cancer genomes of tumours derived from germline BRCA1 and
BRCA2 mutations carriers
//www.cimr.cam.ac.uk/study/clinicians/current_fellows.html
Nik-Zainal S et al. (2012)
The life history of 21 breast cancers.
Cell. 149:994-1007.
//www.ncbi.nlm.nih.gov/pubmed/22608083
Nik-Zainal S et al. (2012)
Mutational processes molding the genomes of 21 breast cancers.
Cell.149: 979-93.
//www.ncbi.nlm.nih.gov/pubmed/22... 阅读全帖 |
|
s*****g
发帖数: 7857 | 7 The integrity of cholesterol-enriched microdomains is essential for the
constitutive high activity of protein kinase B in tumour cells
PMID: 15494028
Cholesterol-depleting agent induces dephosphorylation of PKB/Akt in class I-
deficient B16BL6-8 and B16BL6-9 cells
咋和我的结果想反呢?也许我的癌细胞系原来就没有constitutive high activity of
AKT? |
|
n*********b
发帖数: 140 | 8 Weinberg在1999年在Nature上报道了转化3个或4个基因就足已使人fibroblast转化为癌
细胞。由于大多数癌细胞具备干细胞特征，这就意味着转化3个或4个基因就足已使人
fibroblast转化干细胞。事实上Yamanaka因子之一是c-MYC.
Nature. 1999 Jul 29;400(6743):464-8.
Creation of human tumour cells with defined genetic elements.
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. |
|
a*******a
发帖数: 4233 | 9 王俊：我、 我、我、我、我.......我必须要打断，单细胞的癌症基因组测序完完全全
是我提出来的，完全在组里面独立做的
印象中这是single cell的第一篇。 王俊有更早的么？
Tumour evolution inferred by single-cell sequencing
Nicholas Navin1, 2 Jude Kendall1 Jennifer Troge1 Peter Andrews1 Linda
Rodgers1 Jeanne McIndoo1 Kerry Cook1 Asya Stepansky1 Dan Levy1 Diane
Esposito1 Lakshmi Muthuswamy3 Alex Krasnitz1 W. Richard McCombie1 James
Hicks1 Michael Wigler1
Nature Volume: 472, Pages: 90–94 Date published: (07 April 2011) DOI:
doi:10.1038/nature09807
http://www.nature.com/nat... 阅读全帖 |
|
l**********1
发帖数: 5204 | 10 You are welcome.
Btw, plus one Oxford PI her Nature sister article:
PMID 21076401
HTTP: //www.ncbi.nlm.nih.gov/pubmed/21076401
and more pls go to
HTTP: //www.rob.ox.ac.uk/research/researchgroups/madalena-tarsounas
Ps: in 4 hrs she will give one lecture:
"BRCA1 and BRCA23 tumour suppressors in genome integrity and tumorigenesis"
by
Dr Madalena Tarsounas
Radiation Oncology & Biology, University of Oxford
Cancer Seminar Series
Tuesday 12-Feb-2013
Location:
yyyy, zzzz, xxx , n pm |
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S**********e
发帖数: 1789 | 11 给你看看我们系刚进来的助理教授
Vanderbilt University School of Medicine
Fingleton, Barbara Mary , Ph.D. Assistant Professor of Cancer Biology
Publications
Barrett, CW, Fingleton, B, Williams, A, Ning, W, Fischer, MA, Washington, MK
, Chaturvedi, R, Wilson, KT, Hiebert, SW, Williams, CS. MTGR1 is required
for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.
Cancer Res, 71(4), 1302-12, 2011.
Koon, HB, Fingleton, B, Lee, JY, Geyer, JT, Cesarman, E, Parise, RA, Egorin,
MJ, Dezube, BJ... 阅读全帖 |
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p****e
发帖数: 105 | 12 Good, thanks.
Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by
stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound
healing tissue in vivo and in bone marrow cultures in vitro: implications
for the assessment of lymphangiogenesis. J Pathol. 209:67–77. |
|
l**********1
发帖数: 5204 | 13 cited from OX dot ac dot uk
6 gene sequencing test for cancer patients on the NHS
Health
Science 25 Mar 13
The first multi-gene test that can help predict cancer patients' responses
to treatment using the latest DNA sequencing techniques has been launched in
the NHS, thanks to a partnership between scientists at the University of
Oxford and Oxford University Hospitals NHS Trust.
The test detects mutations across 46 genes in cancer cells, mutations which
may be driving the growth of the cancer in... 阅读全帖 |
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m*******5
发帖数: 45 | 14 Clin Exp Immunol. 2013 Jun;172(3):500-6. doi: 10.1111/cei.12069.
Simultaneous blockade of programmed death 1 and vascular endothelial growth
factor receptor 2 (VEGFR2) induces synergistic anti-tumour effect in vivo.
Yasuda S, Sho M, Yamato I, Yoshiji H, Wakatsuki K, Nishiwada S, Yagita H,
Nakajima Y.
PMID:
23600839
[PubMed - in process]
email, m********[email protected]
thanks a lot. |
|
h********8
发帖数: 49 | 15 索性把我最近看的文献的摘要发出来。有谁看到有趣的做癌症诊断的公司，麻烦告诉我
一声哈。谢谢！
约翰斯•霍普金斯大学Kimmel癌症中心
（文献1， 2012年11月） 不依赖于已知癌症基因组成而检查肿瘤DNA的方法。研究人员
从取自10位结肠癌和乳腺癌患者的血液标本里分离出DNA。然后，他们使用下一代DNA测
序技术读取了血液DNA中的全部基因组。结果显示，癌症患者的血液DNA都出现了染色体
拷贝变化和重排，而10个健康对照组成员的DNA没有异常。
癌症患者血液中来自肿瘤的DNA所占比例从1.4%到47.9%，差异很大。这种新检测法还可
能需要从肿瘤DNA低于0.1%的血液样本中检查出小的、可治愈的肿瘤。只需要做更多的
测序就能克服这些困难。这项实验有望在未来5到10年内用于临床
（文献2，2013年1月）利用常规巴氏检测（Pap test）获得的宫颈分泌物来检测卵巢癌
及子宫内膜癌。在一项初步研究中，研究人员采用这种命名为“PapGene”的测试方法
，依靠全基因组测序癌症特异性突变，检测出了全部24个子宫内膜癌，以及22个卵巢癌
其中的9个，准确率分别为100%和41%... 阅读全帖 |
|
m******g
发帖数: 467 | 16 求提高效率！求上帝保佑（非基督徒）！
Nature 14.01.23
稍微了解一下：
1. Diet rapidly and reproducibly alters the human gut microbiome
2. Discovery and saturation analysis of cancer genes across 21 tumour types |
|
m******g
发帖数: 467 | 17 求提高效率！求上帝保佑（非基督徒）！
Nature 14.01.23
稍微了解一下：
1. Diet rapidly and reproducibly alters the human gut microbiome
2. Discovery and saturation analysis of cancer genes across 21 tumour types |
|
f******g
发帖数: 1003 | 18 High-throughput screening of a CRISPR/Cas9 library for functional genomics
in human cells
Yuexin Zhou, Shiyou Zhu, Changzu Cai, Pengfei Yuan, Chunmei
Li, Yanyi Huang & Wensheng Wei
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour
suppression
Hong Wen, Yuanyuan Li, Yuanxin Xi, Shiming Jiang, Sabrina
Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia,
Jun Wu, Bing Li, Michelle C. Barton, Wei Li... 阅读全帖 |
|
d*******7
发帖数: 39 | 19 Tumour necrosis factor and cancer treatment: a historical review and
perspectives |
|
C*********h
发帖数: 83 | 20 大致读了文章的摘要，应该是cell death领域的同行，做的方向主要还是apoptosis的
下游，呼吸链如何影响apoptosis的，以及cancer specific apoptosis以及ER-
mitochondria contact。
从Grimm的文章来看，他即便不是杰出的科学家，也是一个decent scientist。希望他
Rest in Peace.
如这篇review，citation 139.
The permeability transition pore in cell death.
Apoptosis. 2007 May;12(5):841-55. Review
这篇2011的EMBO J的citation是 81
Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform
for apoptosis induction
Apoptosis重要的东西基本都做的差不多了，确实没什么可以做的。大lab都在做
physiology,做各种小鼠模型。Grimm凭一己之力做... 阅读全帖 |
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s**e
发帖数: 1523 | 21 http://www.ncbi.nlm.nih.gov/pubmed/24798974
Tumour Biol. 2014 Aug;35(8):7369-82. doi: 10.1007/s13277-014-2006-x. Epub
2014 May 6.
Tumor protein D52 (TPD52) and cancer-oncogene understudy or understudied
oncogene?
Byrne JA1, Frost S, Chen Y, Bright RK.
谢谢各位大侠！ |
|
w***r
发帖数: 709 | 22 Reversible epigenetic down-regulation of MHC molecules by devil facial
tumour disease illustrates immune escape by a contagious cancer.
防止癌化? |
|
w***r
发帖数: 709 | 23 Reversible epigenetic down-regulation of MHC molecules by devil facial
tumour disease illustrates immune escape by a contagious cancer.
防止癌化? |
|
W*******1
发帖数: 4 | 24 Creative Diagnostics offers a wide variety of ELISA kits. Including HIV Ag-
Ab, Syphilis screening Kits, Hormone assays, TORCH, infectious disease,
Allergy, diabetes and Tumour Markers. Our prime aim is to ensure that our
clients have easy access to our product portfolio. Our range covers kits
that use the latest generation technology available for the highest
sensitivity assays on the Market, through to cost effective established kits
offering the best value for money. Each of our kit is put th... 阅读全帖 |
|
j*b
发帖数: 341 | 25 读了一下文章， 有五篇文章做出过蛋白激酶活性（四篇老中一片老韩）
最先说PEP能当ATP用的，就是这篇文章的作者本人。
跟风跟到马蹄上了？？
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nat
Commun. 2014
SAICAR induces protein kinase activity of PKM2 that is necessary for
sustained proliferative signaling of cancer cells.
Mol Cell. 2014
PKM2 regulates chromosome segregation and mitosis progression of tumor cells
. Mol Cell. 2014
PKM2 phosphorylates histone H3 and promotes gene transcription and
tumorigenesis. Cell. 2012
Pyruvate kinase M2 reg... 阅读全帖 |
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l********n
发帖数: 260 | 26 1. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M,
Chen D, Sun Y, Woodward W, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC,
Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage
response and radioresistance through CHK1. Nat Cell Biol. In Press.
2. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-
Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces
epithelial-mesenchymal transition but suppresses tumorigenesis, migration
a... 阅读全帖 |
|
b*****2
发帖数: 94 | 27 Please help find the paper:
Patient-derived tumour xenografts as models for oncology drug development
By: Tentler, John J.; Tan, Aik Choon; Weekes, Colin D.; et al.
NATURE REVIEWS CLINICAL ONCOLOGY Volume: 9 Issue: 6 Pages: 338-350
Published: JUN 2012
Many thanks. |
|
S*********e
发帖数: 127 | 28 1) High-throughput screening using patient-derived tumor xenografts to
predict clinical trial drug response.
Gao H, Korn JM, Ferretti S, Monahan JE, Wang Y, Singh M, Zhang C, Schnell C,
Yang G, Zhang Y, Balbin OA, Barbe S, Cai H, Casey F, Chatterjee S, Chiang
DY, Chuai S, Cogan SM, Collins SD, Dammassa E, Ebel N, Embry M, Green J,
Kauffmann A, Kowal C, Leary RJ, Lehar J, Liang Y, Loo A, Lorenzana E, Robert
McDonald E 3rd, McLaughlin ME, Merkin J, Meyer R, Naylor TL, Patawaran M,
Reddy A, Rö... 阅读全帖 |
|
S*********e
发帖数: 127 | 29 and this one as well. THanks again.
Molecular analysis of circulating tumour cells-biology and biomarkers.
Krebs MG, Metcalf RL, Carter L, Brady G, Blackhall FH, Dive C.
Nat Rev Clin Oncol. 2014 Mar;11(3):129-44. doi: 10.1038/nrclinonc.2013.253.
Epub 2014 Jan 21. Review. |
|
|
发帖数: 1 | 31 Tumour Biol. 2016 Jul 27. [Epub ahead of print]
Overexpression of long non-coding RNA TUG1 predicts poor prognosis and
promotes cancer cell proliferation and migration in high-grade muscle-
invasive bladder cancer.
Iliev R1, Kleinova R1, Juracek J1,2, Dolezel J3, Ozanova Z1, Fedorko M4,
Pacik D4, Svoboda M1,2, Stanik M5, Slaby O6,7.
my Email: [email protected]/* */
Thank you very much. |
|
ri
发帖数: 56 | 32 The p53-independent induction of apoptosis in breast cancer cells in
response to proteasome inhibitor bortezomib
Yerlikaya A1, Okur E, Ulukaya E.
Tumour Biol. 2012 Oct;33(5):1385-92. doi: 10.1007/s13277-012-0386-3. Epub
2012 Apr 4.
请回复此贴或发邮件至[email protected]/* */
谢谢！ |
|
j**h
发帖数: 126 | 33 nature.com
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Volume 544
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Article
NATURE | NEWS
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Compass protein attracts heap of criticism
Debate grows over a molecule implicated in animal navigation.
David Cyranoski
04 April 2017
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George Grall/NGC
The red-spotted newt and many other animals can somehow sense Earth’s
magnetic field.
For decades, scientists have wondered how animals c... 阅读全帖 |
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S*********e
发帖数: 127 | 34 Nature. 2015 Jul 9;523(7559):231-5. doi: 10.1038/nature14404. Epub 2015 May
11.
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity.
Spranger S1, Bao R2, Gajewski TF3. |
|
W*********t
发帖数: 204 | 35 庆祝一把：）
Nature Materials
Published online: 9 August 2009 | doi:10.1038/nmat2509
http://www.nature.com/nmat/journal/vaop/ncurrent/abs/nmat2509.html
A dual-emissive-materials design concept enables tumour hypoxia imaging
Guoqing Zhang1, Gregory M. Palmer2, Mark W. Dewhirst2 & Cassandra L.
Fraser1
Luminescent materials are widely used for imaging and sensing owing to
their high sensitivity, rapid response and facile detection by many
optical technologies1. Typically materials must be chemically tail |
|
y***e
发帖数: 6082 | 36 ☆─────────────────────────────────────☆
WhiteMerlot (Merlot) 于 (Sun Aug 9 14:04:56 2009, 美东) 提到:
庆祝一把：）
Nature Materials
Published online: 9 August 2009 | doi:10.1038/nmat2509
http://www.nature.com/nmat/journal/vaop/ncurrent/abs/nmat2509.html
A dual-emissive-materials design concept enables tumour hypoxia imaging
Guoqing Zhang1, Gregory M. Palmer2, Mark W. Dewhirst2 & Cassandra L.
Fraser1
Luminescent materials are widely used for imaging and sensing owing to
their high sensitivity, rapid r |
|
|
s****l
发帖数: 820 | 38 【作者】:
Liu, Dongwu; Chen, Zhiwei
【文题】:
The Effects of Cantharidin and Cantharidin Derivates on Tumour Cells
【期刊名，年份，卷，起止页码】:
Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal
Chemistry, Volume 9, Number 4, May 2009 , pp. 392-396(5)
【链接】:
【求助者email】:
z******[email protected]
【求助者是否发包子】:
baozi :) |
|
m********8
发帖数: 314 | 39 比较奇怪这个5.5 nm的数据也能成论文重点。
"Previously, we have shown that rigid spherical nanoparticles such as
quantum dots can be cleared by the kidneys if they have a hydrodynamic
diameter of approximately 5.5 nm and a zwitterionic surface charge2. Here,
we show that quantum dots functionalized with high-affinity small-molecule
ligands that target tumours can also be cleared by the kidneys if their
hydrodynamic diameter is less than this value, which sets an upper limit of
5–10 ligands per quantum dot for rena |
|
|
w******e
发帖数: 953 | 41 Curr Stem Cell Res Ther. 2016;11(7):593-602.
The Effect of Tumour Necrosis Factor-α on Periodontal Ligament Stem Cell
Differentiation and the Related Signaling Pathways. |
|
s*****o
发帖数: 48 | 42 【 以下文字转载自 ComputerGraphics 讨论区 】
发信人: slishuo (slishuo), 信区: ComputerGraphics
标 题: Special Issue on Computational Methods and Clinical Applica (转载)
发信站: BBS 未名空间站 (Mon Dec 3 23:33:47 2012, 美东)
发信人: slishuo (slishuo), 信区: CS
标 题: Special Issue on Computational Methods and Clinical Applications for Spine Imaging
关键字: Special Issue
发信站: BBS 未名空间站 (Mon Dec 3 23:15:01 2012, 美东)
Computerized Medical Imaging and Graphics (CMIG)
Special Issue on Computational Methods and Clinical Applications for Sp... 阅读全帖 |
|
|
U******u
发帖数: 5829 | 44 absolutely!
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
by Who
ISBN: 9283-22431-0
ISBN 13: 978-9283-22431-0
Publisher: Who Pubns Centre USA
Publish Date: October 2008
Binding: Paperback
List Price: USD 122.00 |
|
t*d
发帖数: 1290 | 45 Found a comment on this question from today's Nature.
====
Change of purpose
Nature 465, 267–268 Date published: (20 May 2010)
In 2007, a paper in the journal Cancer Cell announced that the compound
dichloroacetate (DCA) had been found to shrink tumours in rats (S. Bonnet et
al. Cancer Cell 11, 37–51; 2007). That news by itself would not have
created much of a stir: many compounds tested in rodents raise hopes of
their becoming potential cures, and almost as many go on to fail in human |
|
s*****o
发帖数: 48 | 46 【 以下文字转载自 ComputerGraphics 讨论区 】
发信人: slishuo (slishuo), 信区: ComputerGraphics
标 题: Special Issue on Computational Methods and Clinical Applica (转载)
发信站: BBS 未名空间站 (Mon Dec 3 23:33:47 2012, 美东)
发信人: slishuo (slishuo), 信区: CS
标 题: Special Issue on Computational Methods and Clinical Applications for Spine Imaging
关键字: Special Issue
发信站: BBS 未名空间站 (Mon Dec 3 23:15:01 2012, 美东)
Computerized Medical Imaging and Graphics (CMIG)
Special Issue on Computational Methods and Clinical Applications for Sp... 阅读全帖 |
|
v*****e
发帖数: 30 | 47 感谢Icetea!
Here is the info:
patient age: 41
Family history: no breast cancer family history
medical history: no
Breast cancer with modified right radical mastectomy (right breast) and
axillary lymph node
dissection on 20th of May, 2011.
A lump under her right armpit was self-found but it was not checked out
until 1 and a half months later.
Her histopathology report has revealed that a tumour which was noted to be
at 2.5cm from the top of the nipple, 2.5 cm from the nipple.
It is also rep... 阅读全帖 |
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W********s
发帖数: 1851 | 48 时多时少，多的时候比你这个只多不少，哗哗的，这都是没有任何磕碰的情况下。我家
俩娃都这样，春秋时次数频繁些。
tumour |
|
s*u
发帖数: 1778 | 49 别担心了。我们多的时候很多。。。半盒纸巾那个样子吧。。。我们朵朵早就炼成一手
能提前预测鼻血来临 （即使是半夜睡的正香的情况下），然后一手飞速拿纸巾捂鼻子，
一手按住鼻梁两侧止血的武功了。。。
tumour |
|
