v***a
发帖数: 1242 | 1 tyrosine kinase除了可以phosphorylate tyrosine residues，还能phosphorylate其
它的residues吗？比如Threonine和Serine？谢谢！ |
|
v***a
发帖数: 1242 | 2 一个non-receptor tyrosine kinase，在我进行某种与cell migration有关的诱导后，
它的protein level下降了，但它其它的磷酸化形式都没有变化（WB结果）。根据其它
的条件，实验中的cell migration应该增加，但我查了很多文献，几乎所有的
reference都说这个non-receptor tyrosine kinase的protein level下降的话是因为
cell migration减少。
难道是我的观察有误吗？但实验重复来重复去，结果都高度一致，真是想不通啊！上来
问问大家，看看有没有遇到类似情况的？ |
|
g*****n
发帖数: 241 | 3 我在E. coli里面表达两种不同的receptor tyrosine kinase的kinase domain，结果一
个有tyrosine kinase activity，一个没有。请问这种情况常见吗？该怎么优化才能使
得它有kinase activity啊？
谢谢！ |
|
f*****Y
发帖数: 20 | 4 请问各位达人：
需要做site directed mutagenesis to mimic tyrosine phosphorylation,
应该把tyrosine变成什么residue？
谢谢！ |
|
m***o
发帖数: 272 | 5 该怎么解释呢？transporter有问题？减少，或者活性不行？哪个蛋白是专门的
tyrosine transporter吗？查到什么L system，但还是不明白。AA 的转运受什么调节
呢？请高人指点一二，谢谢 |
|
l**********1
发帖数: 5204 | 6 Here you go
Deramaudt TB et al. (2011)
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion
turnover and cell protrusion.
Mol Biol Cell. 22: 964-75.
Abstract
Cell migration is a highly complex process that requires the coordinated
formation of membrane protrusion and focal adhesions (FAs). Focal adhesion
kinase (FAK), a major signaling component of FAs, is involved in the
disassembly process of FAs through phosphorylation and dephosphorylation of
its tyrosine residues, but ... 阅读全帖 |
|
A********e
发帖数: 354 | 7 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
s*****g
发帖数: 7857 | 8 http://en.wikipedia.org/wiki/Imatinib
tyrosine-kinase inhibitor
is a tyrosine-kinase inhibitor used in the treatment of multiple cancers,
most notably Philadelphia chromosome-positive (Ph+) chronic myelogenous
leukemia (CML).[1] Like all tyrosine-kinase inhibitors, imatinib works by
preventing a tyrosine kinase enzyme, in this case BCR-Abl, from
phosphorylating subsequent proteins and initiating the signaling cascade
necessary for cancer development, thus preventing the growth of cancer cells
an... 阅读全帖 |
|
c**i
发帖数: 6973 | 9 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
p*******g
发帖数: 2976 | 10 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
O***n
发帖数: 13127 | 11 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
c**i
发帖数: 6973 | 12 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
a********k
发帖数: 2273 | 13 花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branches in lamellipodia. Cell. 2008 Sep
5;134(5):828-42. PubMed PMID: 18775315; PubMed Central PMCID: PMC2570342.
Cai L, Makhov AM, Bear JE. F-actin... 阅读全帖 |
|
h**********d
发帖数: 30 | 14 是这样的啊，呵呵，多谢。
我的体系其实不会遇到这么极端的情况，其实就是很单一的L构型的芳香氨基酸，是纯
的物质，而且我想在水溶液中也不会有什么激发波长或者吸收光谱区分和明显的isomer
,tautomer存在吧。
我提出这个问题是因为看到文献里说L-3-AMINO-TYROSINE他们用288 nm激发，但是我自
己去测了一下这个非天然氨基酸的吸收光谱，吸收的峰值在280 nm和274 nm,288 nm已
经是很弱的吸收了，所以不太明白文献里为什么说激发3-L-AMINO-TYROSINE选择的是
288 nm,这样就可以避开体系里phenylalanine,tyrosine的激发了么，虽然tyrosine,
phenylalanine的量子产率都低很多。
1. [BBA, 439(1976)470-478, fluorescence of aminotyrosyl residues formed in
ribonuclease A]
另外体系里如果有tryptophan,是不是更加不可能区分得开3-amino-tyrosine和trp的发
射光谱信号了？
2.http://dwb... 阅读全帖 |
|
c**i
发帖数: 6973 | 15 Peter Landers, New Breast Cancer Drug Found Deep in the Sea. Wall Street
Journal, Jan. 4, 2010.
http://online.wsj.com/article/SB1000142405274870411150457605977
("A study found it [Halaven] extended the life of patients with advanced
breast cancer by about two-and-1/2 months, to 13 months")
My comment:
(a) Eisai Co., Ltd. エーザイ株式会社
(a public company; headquarters Tokyo; established in 1941 by Toyoji NAITO
内藤 豊次 as Nohon Eisai Co., Ltd. 日本衛材（衛生材料の略。具体的には絆創膏
や包帯の事))
ja.wikipedia.org
(b) eribulin
htt... 阅读全帖 |
|
p*******g
发帖数: 2976 | 16 【 以下文字转载自 Biology 讨论区 】
发信人: albertsmwk (.)(.), 信区: Biology
标 题: 第一批“青年千人计划”生物类@publication列表@
发信站: BBS 未名空间站 (Thu Aug 18 15:04:16 2011, 美东)
花了一个小时，深深的鄙视一下自己的无聊行径！！
125 蔡亮 男 1980年11月 复旦大学 生命
科学 2007年12月毕业于[美国]北卡大学 [美国]加州大学旧金山分校 博士后
Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13;139(4):660-2. PubMed
PMID: 19914162; PubMed Central PMCID: PMC2900917.
Cai L, Makhov AM, Schafer DA, Bear JE. Coronin 1B antagonizes cortactin and
remodels Arp2/3-containing actin branche... 阅读全帖 |
|
h**********d
发帖数: 30 | 17 基本情况：
E.coli C43, cyoABCDE knockout(Km)表达cytochrome bo3, tyrA knockout(Cm)
tyrosine生物
合成中的一个酶（从prehenate到4-hydroxy-phenylpyruvate)
pAc-YNH2 plasmid(Tet): proK promoter + 6 copy of M.j tyrosine tRNA, glnS
promoter
+ 3-aminno-tyrosine M.j tRNA synthase (M.j is an archea strain)
pET plasmid(Amp): T7 cyoABCDE w/ cyoB Y288Amber stop codon mutation
要表达的是cytochrome bo3 mutant protein, 在蛋白里genetically引入一个非天然氨
基酸
（peter schultz组的技术，pAc-YNH2质粒也是从他们组拿给MIT的STUBBE组做的，她们
组没遇
到过这个质粒的问题）
这两个质粒同时存在于E.coli c43里的时 |
|
z*t
发帖数: 863 | 18 Beutler得奖，Medzhitov会不会有意见？
http://www.sciencedirect.com/science/article/pii/S1074761309002
Ruslan Medzhitov
This year marks the 20th anniversary of a publication (Janeway, 1989) that
in many ways revolutionized our understanding of the immune system. As part
of the proceedings of the Cold Spring Harbor Symposium on Immune Recognition
, the paper authored by the late Charles A. Janeway, Jr. was not a standard
peer-reviewed publication. In fact, Charlie used to refer to it as “the
best paper I've ... 阅读全帖 |
|
s**u
发帖数: 9035 | 19 He has 12 papers, 3 of which are first-author papers. see below
Differential regulation of androgen receptor by PIM-1 kinases via
phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Linn DE, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li
W, Xu K, Chen M, Qiu Y.
J Biol Chem. 2012 Jun 29;287(27):22959-68. Epub 2012 May 14.
PMID:
22584579
[PubMed - indexed for MEDLINE]
Related citations
2.
A Role for OCT4 in Tumor Initiation of Drug-Resistant Prostat... 阅读全帖 |
|
s**u
发帖数: 9035 | 20 Dr.Xie has 12 papers, 3 of which are first-author papers. see below
Differential regulation of androgen receptor by PIM-1 kinases via
phosphorylation-dependent recruitment of distinct ubiquitin E3 ligases.
Linn DE, Yang X, Xie Y, Alfano A, Deshmukh D, Wang X, Shimelis H, Chen H, Li
W, Xu K, Chen M, Qiu Y.
J Biol Chem. 2012 Jun 29;287(27):22959-68. Epub 2012 May 14.
PMID:
22584579
[PubMed - indexed for MEDLINE]
Related citations
2.
A Role for OCT4 in Tumor Initiation of Drug-Resistant Pro... 阅读全帖 |
|
p*l
发帖数: 1359 | 21 按这个文献的说法，选了较长的激发波长，这样tyrosine激发就不那么强了（tyrosine
激发峰在276nm)。但是tryptophan的激发峰在280 nm,3-L-AMINO-TYROSINE的峰也在
280左右（你自己的测量），所以死活是避不开分不清的。 |
|
j*****g
发帖数: 8 | 22 Adjuvant systemic therapy in resectable non-small cell lung cancer
Author
Nasser Hanna, MD
Section Editors
Rogerio C Lilenbaum, MD, FACP
James R Jett, MD
Deputy Editor
Sadhna R Vora, MD
Contributor disclosures
All topics are updated as new evidence becomes available and our peer review
process is complete.
Literature review current through: May 2016. | This topic last updated: Nov
30, 2015.
MOLECULARLY TARGETED AGENTS — Despite the activity of tyrosine kinase
inhibitors in patients with metastat... 阅读全帖 |
|
l*h
发帖数: 4124 | 23 Ponatinib is a new drug approved for patients with Ph+ ALL. Preliminary
results show it is superior to other tyrosine kinase inhibitors in Ph+ ALL.
It should not be available in China now.
Imatinib, dasatinib etc should be easier to obtain.
Dose scaling in pediatric patients of tyrosine kinase inhibitors: should be
based on body surface area, not on body weight.
L |
|
l*h
发帖数: 4124 | 24 Ponatinib is a new drug approved for patients with Ph+ ALL. Preliminary
results show it is superior to other tyrosine kinase inhibitors in Ph+ ALL.
It should not be available in China now.
Imatinib, dasatinib etc should be easier to obtain.
Dose scaling in pediatric patients of tyrosine kinase inhibitors: should be
based on body surface area, not on body weight.
L |
|
g***j
发帖数: 40861 | 25 要速度，谢谢啊。
不过还是有点问题啊。
这是我的程序
open(in_file,"
while ($line=)
{($field1,$field2,$field3,$field4)=split',',$line;
if ($field4=~ /.\s./) {print "$field1,"$field4"";}
else {print "$field1,$field4";}
}
close (in_file);
这是我的结果
TTT,Phenylalanine
TTC,Phenylalanine
TTA,Leucine
TTG,Leucine
TCT,Serine
TCC,Serine
TCA,Serine
TCG,Serine
TAT,Tyrosine
TAC,Tyrosine
TAA,Stop
TAG,Stop
TGT,Cysteine
TGC,Cysteine
TGA,Stop
TGG,Tryptophan
CTT,Leucine
CTC,Leucine
CTA,Le |
|
L******e
发帖数: 679 | 26 My boss want me to find out exactly how many protein kinases (among them,
how many tyrosine kinases and serine/threonine kinases) and lipid kinases in
human beings.
I chekced several references and a website " www.kinase.com'
I got the follows:
1, 518 kinases. 90 are Tyrosine kinases.
I cannot find the number of serine/threonine kinases and lipid kinases, even
though i searched many published papers.
Roughly, the protein kinase was mainly classified as TK and STK, but there
is still some other |
|
l**********1
发帖数: 5204 | 27 Did you try test the level of leakiness with no isotope label actin?
i mean whether your target even abundantly but still holded entirely intra- cellular tyrosine-
containing protein, such as actin or tubulin:
then your negative control with 35S labeled that also became Immunoprecipitation positively
Details please go to
Protocol full text link:
//webdoc.nyumc.org/nyumc/files/sun-lab/attachments/CPCB.ch07.Protein%
20Labeling.pdf
cited :
>For many applications, an important control for surface-l... 阅读全帖 |
|
l**********1
发帖数: 5204 | 28 Did you try test the level of leakiness with no isotope label actin?
i mean whether your target even abundantly but still holded entirely intra- cellular tyrosine-
containing protein, such as actin or tubulin:
then your negative control with 35S labeled that also became Immunoprecipitation positively
Details please go to
Protocol full text link:
//webdoc.nyumc.org/nyumc/files/sun-lab/attachments/CPCB.ch07.Protein%
20Labeling.pdf
cited :
>For many applications, an important control for surface-l... 阅读全帖 |
|
z********i
发帖数: 610 | 29 多谢。我还有一个问题请教。如果tyrosine的-OH和R的侧链氨基是5.5A，那么tyrosine
被磷酸化以后，他们之间能相互在用吗？
因为手上有个蛋白能磷酸化激活，但是不知道机制，它的晶体结构已知，所以我想看看
是不是dimerization激活它。
Thanks |
|
J*****n
发帖数: 1041 | 30 Could anyone help to find a full text publication? Thanks!
http://www.citeulike.org/user/czarfv/article/9447330
Functional expression in Escherichia coli of the tyrosine-inducible tyrosine
ammonia-lyase enzyme from yeast Trichosporon cutaneum for production of p-
hydroxycinnamic acid
by: Todd Vannelli, Zhixiong Xue, Sabine Breinig, Wei W. Qi, F. Sima
Sariaslani
Enzyme and Microbial Technology, Vol. 41, No. 4. (3 September 2007), pp. 413
-422, doi:10.1016/j.enzmictec.2007.03.013 Key: citeulike:9... 阅读全帖 |
|
|
f*******K
发帖数: 34 | 32 我知道这篇文章，Sample Multiplexing with Cysteine-Selective Approaches:
cysDML and cPILOT, 相关工作在ASMS会议报道过。他们所用的方法基本还是基于传统
方法改良如Thiopropyl Sepharose 6B resin和Cys TMT，这些基于抗体和resin方法的
富集效率比较低，从鉴定数目就可以看到。我们的富集效率可以达到97%，很轻松鉴定
到10000+ unique peptides。
目前没有同时含有iodoacetamide+phosphate的tag。phosphate可能会被phosphatase酶
切掉，phosphonate不能，因此更加稳定。
至于为什么要富集Cys peptide,因为其low abundance,essential for the biological
activity and structure, highly sensitive and reactive.
同时富集目的是研究PTM crosstalk.在我的文章里面有很好的例子，protein tyrosine
... 阅读全帖 |
|
r********n
发帖数: 7441 | 33 发信人: conti (conti), 信区: TsinghuaCent
标 题: zz pk饶毅进入第二轮的张旭的背景
发信站: 水木社区 (Sun Aug 28 15:38:09 2011), 站内
如果神经方向就只能上一个候选人，那么张旭入选还真是一点也不出格
发信人: WeiLiao (WeiLiao), 信区: Biology
标 题: 张旭的publications
发信站: BBS 未名空间站 (Sun Aug 28 01:39:20 2011, 美东)
去查了一下，张旭总共发表了90多篇英文文章（不算中文）。回国之后作为联系作者也
有快20篇了。其中有cell, neuron, Journal of neuroscience, PNAS 好多篇。
而且他
1995年就回国了，那个时候国内的环境有多差不用说了吧。这也快20年了。比饶益
2007
年才全职回去多了12年。比起培养的中国学生也多多了，算国内贡献肯定不会小。如果
他一直留在国外，成就未必就比饶差。谁把饶益的文章列一列。国内多少篇，总共多少
篇，培养了多少中国学生？
1. Li KC, Wang F, ... 阅读全帖 |
|
s**i
发帖数: 4448 | 34 医学是基于现代生物，化学和各种技术的进展来发展的。哪里只单靠统计。
随便几个例子，
HIV protease inhibitor,ACE inhibitor都是成功的structure-based drug design的
例子。
Imatinib 作为 bcr-Abl tyrosine-kinase inhibitor, 可以治愈chronic myelogenous
leukemia (慢性粒细胞白血病）
这都是在对疾病机理在分子水平上的了解以后设计的针对性药物，挽救了成千上万人的
生命。
现代医学的成就不要太多（消灭传染病比如麻风之类的就不说了），甩古老神奇的中医
以光年计。
贬西医抬中医，纯粹是无知所致。 |
|
y**********g
发帖数: 2285 | 35 菘蓝根含靛蓝（indigotin，indigo），靛玉红（indirubin），蒽醌类、β-谷甾醇（
β-sitosterol），γ-谷甾醇（γ-sitosterol）以及多种氨基酸：精氨酸（arginine
），谷氨酸（glutamic acid），酪氨酸（tyrosine），脯氨酸（proline），缬氨酸（
valine），γ-氨基丁酸（γ-aminobu-tyric acid）。还含黑芥子甙（sinigrin），靛
甙（indoxyl-β-
hlucoside），色胺酮（trptanthrin），1-硫氰酸-2-羟基丁-3-烯（l-thiocyano-2-
hydroxy-3-butene），表告伊春（epigoitrin），腺甙（adenosine），棕榈酸（
palmitic acid），蔗糖（sucrose）和含有12%氨基酸的蛋白多糖。
还含有抗革兰氏阳性和阴性细菌的抑菌物质及动力精。 |
|
f***y
发帖数: 4447 | 36 2019年10月17日/医麦客 eMedClub/--今年5月，彭博社引述消息人士透露：新药创
制公司北京诺诚健华医药科技有限公司（以下简称：诺诚健华）计划最快今年内赴港上
市，估值已超8亿美金，计划IPO募资约2.5亿美元。
不出所料，港交所于10月17日披露了诺诚健华的招股说明书，显示摩根士丹利、高
盛为联席保荐人。
▲ 图片来源：招股书
此前，诺诚健华完成了多轮融资，包括A系列、B1系列、B2系列、B3系列、C系列、
D1系列及D2系列系列融资。
▲ 各轮融资概况（图片来源：招股书）
根据招股书，目前诺诚健华的产品尚未获准进行商业销售，尚未从产品销售产生任
何收益。自成立以来的各年度内，概未盈利并产生经营亏损，截至2017年12月31日止年
度及截至2018年12月31日止年度，经营亏损分别为人民币3.417亿元及为5.54亿元，且
截至2018年及2019年6月30日止六个月，经营亏损分别为2.794亿元及3.219亿元。
研发开支方面，截至2017年及2018年12月31日止年度以及截至2019年6月30日止六
個月，该公司的研发开支分別为6290万元、1.497亿元及948... 阅读全帖 |
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S***J
发帖数: 1210 | 37 云老师发了个贴说清华目前的找人标准，很多人不相信。特地调研了一下清华生命学院
最近回去的人的情况，如云老师所说，绝大多数都有2cns，如果只有一篇cns，那基本
上还有>2的子刊。这个不仅仅局限于胖老师经常说的结构生物学，而是所有方向都基本
如此。
当然这些新回去的绝大部分都是千青（有些不是的是因为回去那一年千青还没开始）。
网页上的Title有的是教授，有的是研究员，估计当时还没有统一。但校内一律都是副
教授，也就是相当于这边的AP。我还特地打听了一下，国内的TT制度好像没有Tenured
Associate这一档，清华5年考核通过了就是正经的full professor。
有些老师看不上国内的科研，我就仅列出两位回国后的publication，咱就不说颜宁等
这种Early T的个例了。说两个没太有名气的，还没有评上T的，各位老师可以参考一下
，看看自己有没有别人这么productive。
一. Guangshuo Ou （11年回国，千青）
Select item 25342559
1.CYLD mediates ciliogenesis in multiple organs b... 阅读全帖 |
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I****a
发帖数: 407 | 38 ER or PR (+) means tumor's growth some how is dependent on estrogen and it
is a good predictor as one can give either Tamoxifen or aromatase inhibitor
to block the estrogen. Her2/neu + traditionally means that the tumor is more
aggressive and hard to treat. Since Her2/neu monoclone antibody (herceptin)
is introduced, Her2/neu positivity is not that important because we now can
block the her2 pathway with herceptin and even with small tyrosine kinase
inhibitor such as Tykerb.
Overall for your mom... 阅读全帖 |
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W***M
发帖数: 50 | 39 CML is very treatable since the development of tyrosine kinase inhibitor (
Imatinib). 5 year overall survival increased from 10-20% to 60-70% with TKI.
It is totally worth the money. the key is to take the medicine as long as
it still works. Sometime, CML can be resistant to imatinib, they you can
switch to second generation inhibitor such as dasatinib. |
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l*h
发帖数: 4124 | 40 请问你说的tki中文是什么？
TKIs are tyrosine kinase inhibitors. Imatinib is one of them.
药是格格列位吗？
yes.
请问如果复发还可以再切除吗？
these patients have close followup after the initial surgery. recurrence
would be caught when it's still small and amenable to removal.
癌变和转移的机率大吗？
GISTs are 癌 by behavior. metastasis is mainly short range ones.
谢谢 |
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l*h
发帖数: 4124 | 41 which type, renal cell or uroepithelial? if late stage renal cell, some may
respond to tyrosine kinase inhibitors. conventional chemotherapy and
radiation therapy don't show reasonable efficacy. there are less non-
surgical options for uroepithelial. |
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W********r
发帖数: 158 | 42 Ph+ ALL used to have very poor prognosis and bone marrow transplant is
indicated. 5y overall survival is 20% even with bone marrow transplant.
However, the tyrosine kinase inhibitor such as gleevac (imatinib) completely
changed the disease. In Children's oncology group study, daily gleevac +
chemotherapy, 3 year overall survial is 80%, bone marrow transplant is no
longer recommended in Ph+ ALL patient. Slow reduction of WBC or residual
lymph nodes are very typical for Ph+ ALL that didn't receive... 阅读全帖 |
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l*h
发帖数: 4124 | 43 be very careful if you want to take tyrosine kinase inhibitor. if you want
to do it, do it under a physician's close monitoring.
TKIs cause interstitial pneumonitis (this is a very serious condition,
prognosis worse than non-small cell lung cancer) in some patients. in Japan,
about one in every 20 patients on TKI develop this in a relative short time
of period but they are under close monitoring so are detected early and a
small percentage of them (still about 30%) at irreversible stage. in Chin... 阅读全帖 |
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b*****a
发帖数: 2 | 45 谢谢你的帮助。通过搜索Tyrosine Kinase Inhibitor，找到了几篇专业paper，但还没
有明确的答案Imatinib 和 Sunitinib是否适用于我哥的情况。
再次感谢。 |
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f******g
发帖数: 1003 | 46 http://www.mitbbs.com/article_t/Biology/31787297.html
以前讨论过进中心的条件。
看了几个这两年回去的，
傅肃能
代表性科研论文
1. Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM,
Hotamisligil GS. Polysome profiling in liver identifies dynamic regulation
of endoplasmic reticulum translatome by obesity and fasting. PLoS Genet.
2012 Aug;8(8):e1002902.
2. Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in
hepatic lipid homeostasis and stress signaling. Cell Metab. 2012 May 2;15(5)
:623-34.
3. Fu S... 阅读全帖 |
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l*******o
发帖数: 39 | 47 One reviewer needed for reviewing the following manuscript:
key word: cardiovascular disease, Ischemia/reperfusion injury, VE-cadherin,
Tyrosine phosphatase,cardiomyocytes deth.
molecular biology and medicine
background. Ph.D degree. reviewer experience and first authored paper in high IF journal. Brief CV for your publication, position, institute, research experience and official email. For those who have already sent information to my MIT email box, please don't send again. I will consider you... 阅读全帖 |
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d******8
发帖数: 3017 | 48 Almonds
Nutritional value per 100 g (3.5 oz)
Energy 2,408 kJ (576 kcal)
Carbohydrates 21.69 g
- Starch 0.74 g
- Sugars 3.89 g
- Lactose 0.00 g
- Dietary fiber 12.2 g
Fat 49.42 g
- saturated 3.731 g
- monounsaturated 30.889 g
- polyunsaturated 12.070 g
Protein 21.22 g
- Tryptophan 0.214 g
- Threonine 0.598 g
- Isoleucine 0.702 g
- Leucine 1.488 g
- Lysine 0.580 g
- Methionine 0.151 g
- Cystine 0.189 g
- Phenylalanine 1.120 g
- Tyrosine 0.452 g
- Valine 0.817 g
- Arginine 2.446 g
- Histidine 0.... 阅读全帖 |
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s********g
发帖数: 695 | 49 medicine版是最适合的问的版
http://www.mitbbs.com/bbsdoc/Medicine.html
vandetanib 是针对tyrosine kinase EFGR/VEFGR 的抑制剂。最好先做个基因分析，看
看他是否适合，再决定是否用它。有些类似的药,比如 Erlotinib (Tarceva)可选。
没有处方，处方药和临床药很难在美国弄到，看看AstraZeneca是否会在中国做临床。
三期临床的药，不是正式上市，但有时可以卖（在明显毒副作用发现前）。
btw, they are ridiculously expensive if no insurance. |
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a***a
发帖数: 40617 | 50 vitamin c
calcium
epidyne
caffeine
oleic acid
leucine
methionine
proline
hydroxpro
alchemilla vulgaris extract
olea europaea extract
cuminum cyninum extract
mentha longifolia extract
lipidrol
tyrosine
trans ferulic acid
capsicore
capsicum annuumm |
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