s**********r
发帖数: 330 | 1 去问了一下PK/PD组的同事,他们做POPULATION PK/PD MODELING,不用WINNONLIN,用
NONMEM,所以对WINNONLIN也不很熟悉.IN TERMS OF换行,只针对你举的例子,用土办法:
第一行: Variable 1=a+b+c
第二行: Variable 2=d
第三行: Variable 1 + Variable 2
如果你有其他种换行,POST ALONG THE THREAD.我再帮你问问. |
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c*******g
发帖数: 695 | 2 一行程序如很长想写成2行怎么把一行分开啊？
用什么符合
比如matlab里面好像是...
a=b+c...
+d
相当于a=b+c+d
winnonlin里面这样应该怎么搞啊？
大侠指点一下
谢谢 |
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s**********r
发帖数: 330 | 3 今天一天好多事,没顾上问,明天俺再去问问.唉这WINNONLIN真不USER FRIENDLY. |
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c*******g
发帖数: 695 | 4 发现了
还是C好
想干啥干啥
呵呵
8过FDA认winnonlin
没办法啊
还是得学
呵呵 |
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l******5
发帖数: 3030 | 5 Contact the recruiter directly please
Principal Research Scientist-PK/PD- Indiana -
The Principal Research Scientist functions as a project leader in a
multidisciplinary team environment with primary responsibility for the early
preclinical development of antibodies and protein molecules.
KEY OBJECTIVES/DELIVERABLES:
- Integrate pharmacokinetics and PK/PD with discovery biology to define
structure activity relationships to guide protein engineering strategies and
to help optimize development of ... 阅读全帖 |
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f*********o
发帖数: 38 | 6 欧美药厂在上海职位，更多职位Available
2. Primary Purpose of Job (Job Summary) 主要工作目标（岗位简介）
To provide DMPK support for drug discovery projects from target assessment
to clinical lead selected (CLS) and to lead efforts of investigating DMPK
issues/problems of drug candidates.
3. Principle Roles & Responsibilities / Accountabilities 主要职责/责任
(Major functions of the position) （职位的首
要职能）
a. Serve as an early nonclinical pharmacokinetics and drug metabolism Rep
. for NCS Chin... 阅读全帖 |
|
f*********o
发帖数: 38 | 7 欧美药厂在上海职位，更多职位Available
2. Primary Purpose of Job (Job Summary) 主要工作目标（岗位简介）
To provide DMPK support for drug discovery projects from target assessment
to clinical lead selected (CLS) and to lead efforts of investigating DMPK
issues/problems of drug candidates.
3. Principle Roles & Responsibilities / Accountabilities 主要职责/责任
(Major functions of the position) （职位的首
要职能）
a. Serve as an early nonclinical pharmacokinetics and drug metabolism Rep
. for NCS Chin... 阅读全帖 |
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w********g
发帖数: 447 | 8 恩，routine的确实是master多，但说白了BS也能做。反正小分子质谱的phd不好卖。pk
那边的话除非你pk比较强，会点modeling，最低要求起码玩过winnonlin之类的入门软
件，搭着质谱phd，还有希望。但化学系train出来的质谱phd，没几个人玩过那些。早
几年，质谱没那么傻瓜的时候，玩质谱的还比较好卖。公司无所谓，其他方面不会的话
招进来慢慢train。现在质谱越来越傻瓜，人家开始强调质谱以外的背景。反正现在就
是玩小分子质谱的phd必须绑着至少一个以上的其他skill才能卖出去。即使卖出去了，
过两天没准就被裁了。 |
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x**********0
发帖数: 33 | 9 POSITION SUMMARY
A Senior Scientist who will play a key role in new drug characterization and
analysis using LC/MS in research and development. Major responsibilities
include bioanalytical assay development for drug DMPK studies and peptide/
protein and antibody analysis in support of drug candidate selection,
preclinical and IND-enabling studies
ESSENTIAL FUNCTIONS
- Peptide/protein and antibody analysis using Agilent QTOF
- Developing in vitro DMPK assays using SCIEX QTRAP including meta... 阅读全帖 |
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H**********J
发帖数: 351 | 10 如题
国内药厂有3个Informatics职位招聘，越看越觉得跟药物研发背景关系不大，跟IT倒是
有巨大关系~大家帮忙看看哈~谢谢啦~
1，Early Development Informatics
Qualifications: M.Sc., Ph.D. or equivalent in Computer Science with a
pharmacology or medical background, or an M.Sc., Ph.D. or equivalent
Pharmacology or Medicine with a strong computer science background, in
addition to experience within the Pharmaceutical or Biotech industry.
Working as a member of Early Development Informatics within Pharma Research
and Early Development Informatics at the Roc... 阅读全帖 |
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j******8
发帖数: 12 | 11 We are working with a top Multinational Pharmacy Company to recruit Clinical
Pharmacologist for their R&D center in China (Beijing or Shanghai),
especially in Phase 1/Clinical Pharmacology/PK/PD studies and Clinical
Pharmacology strategy. This position belongs to Early Research Development
Department.
Primary Responsibilities:
• Both build new and apply known disease and drug models as stated
previously. This will be based on clinical trial information inside Roche as
well as the litera... 阅读全帖 |
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i****f
发帖数: 473 | 12 ☆─────────────────────────────────────☆
heartbreaker (march madness) 于 (Sat Apr 29 03:40:11 2006) 提到:
谢谢!
☆─────────────────────────────────────☆
bleu (灵枢素问) 于 (Tue May 2 00:48:26 2006) 提到:
我知道一家公司有的，不过学费要1395美元，你打算自费吗？
☆─────────────────────────────────────☆
bleu (灵枢素问) 于 (Tue May 2 00:49:06 2006) 提到:
哦，不好意思，看错了，我以为你要学winnonlin，原来你是要学pk。自己看书吧，呵呵
。
☆─────────────────────────────────────☆ |
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s**********r
发帖数: 330 | 13 俺很少用WINLONLIN,如果星期二你还没有答案但还想知道的话,我可以帮你问问同事. |
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c*******g
发帖数: 695 | 14 感谢！
这学期学这个课程
老师就大概说了一下这个软件
都是自己在学
很晕菜 |
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c*******g
发帖数: 695 | 15 这个方法我想过了
但是我是在定义变量的时候
只能用一次statement
比如
PNAME ‘k12','k10',....如果变量多了程序就不读了
靠
我数了只能用244个字符
~~~~~~~这个东西太复杂了
我们就上个pkpd的课程
来不及学了
谢谢你帮我问同事 |
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s**********r
发帖数: 330 | 16 你能分两次定义吗? PNAME一批,换行后再定义一批.
我无数年前参加过一个星期的PK/PD TRAINING,是SUNY BUFFALO的PROFESSOR给对PKPD一
窍不通的人办的强化训练班.学完了又不用,现在已经忘得一干二净了.
你写具体些,我明天再去问,我也正好学学. |
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c*******g
发帖数: 695 | 17 好像不行呢
那个生成模型的向导自动生成的就只有一个
PNAMES
又不是C语言
int x
int y
随便写。。。。。 |
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i**f
发帖数: 1195 | 18 我直接回车的，没事，work的很好
nonmem也一样，都是acii的code，没区别 |
|
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s**********r
发帖数: 330 | 20 哪个方向都有OPENING啊,只要有人有PROJECT想招人做.
你不是在学WINNONLIN吗,是做PKPD的吧?那就往那个方向试试.不过SECOND YEAR可能困
难一些,第三/四年多些EXPERIENCE,申请容易些. |
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y***n
发帖数: 27 | 21 也好奇来问一下，
1. PK/PD modeling和biostat的相比，哪个pay的高？比如biostat entry level 一般
pay 8-9w，pk/pd呢?
2.stat phd，with extensive experience in winnonlin,nonmem，在这个行业里是否
不如pk/pd本专业的popular？
因为同学都是做biostat或者marketing的，这个方向缺乏了解，希望版上的牛人们指点
指点 |
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i**f
发帖数: 1195 | 22 I know Winnonlin is required by FDA for individual pk study in industry.
What about population pk? is there any requirement of which software should
be used to conduct the study?
I just browsed the FDA guidance for population pharmacokinetics and didn't
find any information regarding this. it only states "It is crucial that the
software used for population analysis be adequately supported and maintained
."
Does it mean software other than NONMEM can be used, like Monolix? I don’t
want to publis |
|
|
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m********r
发帖数: 127 | 25 这东西也有打折吗？其实我最近也一直想pk pd modeling自学成才一把，不知道有没有
d版的nonmem? lol |
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J******s
发帖数: 377 | 26 搞PK为什么要用matlab呢
WinNonLin之类的更好一些吧 |
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k****o
发帖数: 589 | 27
请大侠推荐一本WinNonLin的书吧，最好是侧重PK PD的。 |
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j******8
发帖数: 12 | 28 We are working with a top Multinational Pharmacy Company to recruit Clinical
Pharmacologist for their R&D center in China (Beijing or Shanghai),
especially in Phase 1/Clinical Pharmacology/PK/PD studies and Clinical
Pharmacology strategy. This position belongs to Early Research Development
Department.
Here’s the JD of this position:
Primary Responsibilities:
• Both build new and apply known disease and drug models as stated
previously. This will be based on clinical trial information in... 阅读全帖 |
|
s*******u
发帖数: 241 | 29 1. you plot your data efficacy vs concentration;
2. you ask your computer program to generate a curve (or you draw one in the
old fashioned way);
3. you find the 50% of the maximum efficacy on the Y;
4. then find the corresponding X!
5. done!
should be able to done in 1 sec in a program... i use Prism, used to use the
expensive WinNonLin during my phd.... |
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k******a
发帖数: 306 | 30 代发，If interested, pls contact: d******[email protected]
Looking for a Director/Associate Director in Clinical Pharmacology Modeling
& Simulation for a global leading pharma in Shanghai, China
Qualifications and Responsibilities:
The role requires doctoral-level training (Ph.D., Pharm.D., or M.D.). An
analytical and inquisitive mind for problem solving and strong written and
oral communication skills are essential. You will be working across the
drug discovery pipeline from pre-candidate selectio... 阅读全帖 |
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k******a
发帖数: 306 | 31 代发，If interested, pls contact: d******[email protected]
Seeking a Director of Clinical Pharmacology for a global leading pharma's R&
D in Shanghai, China
Key Responsibilities:
•Contributes to the overall development of long term strategy for
clinical pharmacology in new drug development in China R&D.
•Align & implement clinical pharmacology related strategies to meet
China R&D objectives
•Contribute to clinical pharmacology strategy in early and late stage
studies as well as in re... 阅读全帖 |
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k******a
发帖数: 306 | 32 Global pharma招聘：Associate Director，DMPK 地点：上海
有意回国发展的专业人才请联系：d******[email protected]
Key Responsibilities：
• Aid the interpretation of the data we generate and integrate it with
supplementary data from outside of DMPK to help drive project decisions.
• Use modeling as a thinking tool to help us generate an
experimentally testable question.
• Develop PK/PD strategies, perform modeling & simulation analyses,
represent DMPK department in project teams, and write reports.
• Exc... 阅读全帖 |
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x****9
发帖数: 36 | 33 有意者请站内联系。
Location：Maryland
JD：
The primary function of a PK Associate Scientist 1/2 is to support Global PK
-PD project leaders and team representatives through all stages of a
candidate drug's development cycle. The PK Associate Scientist 2 will be
responsible for all aspects of PK-related support for biotherapeutics -data
evaluation, interpretation, and reporting. Specifically- preparation of
toxicokinetic reports, clinical PK sub-reports, pre-clinical protocols,
slide preparations, abstracts... 阅读全帖 |
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l******o
发帖数: 3764 | 34 本人pharmacology PhD, phd期间是做 drug screen的，后来因为偶然的机会，postdoc
做了PKPD project,发现自己还挺喜欢这个方向的。
虽然至今为止只有不到两年的经验，但是自己感觉上手还算比较快的（和非华裔学生相
比），希望能在model&simulation方向继续发展
我自己的情况：做过的project有两个popPK,一个PKPD，一个NCA，都是clinical data,
不过所有的Project规模都不大,20-100人的样子
popPK/PKPD都是用NONMEM,NCA用的是WinNonlin
R用的还可以，主要用来data formatting / plotting, 虽然写具体的R script经常需
要google帮忙，但是至今为止需要实现的功能还都实现了
我现在的postdoc做到明年6月，准备开始找工作了
希望能找到entry level clinical PK/Pharmacometrics的工作,以M&S为主
公司不限，但是地方最好是great NYC area, great Boston area, 南加，北加，... 阅读全帖 |
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f****6
发帖数: 4472 | 35 大部分in vitro/in situ assay都有很多assumptions，假如你没亲自做过这些assay就
直接拿现成的data做model，再根据你的model下结论，你觉得这样好吗？会不会做出错
误的结论？楼上上glsmfz727也说咯~
做modeling肯定要有较好的统计和programming的基础啦，比如能熟练使用R，MATLAB，
NONMEM，WinNonlin。这些东西你都要会，不过我觉得这些东西都是工具和手段，更重
要的是要对physiology
, pharmacology, action mechanism以及molecule本身了解透彻。大分子的ADME,
action mechanism以及molecule本身都和小分子完全不同，所以才需要这方面的人才嘛。
PKPD我觉得算是现在最好的一个方向了吧，visibility特别高（因为你要代表整个DMPK
组，还要你来做决定），升值加薪快，跳槽也容易。而且FDA也越来越越接受Modeling
了，你要是有相关的filing的经验，那你无敌了~国内这方面还是空白，以后回国应该
也能吃香喝辣：）
随便侃侃，别... 阅读全帖 |
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s****9
发帖数: 213 | 36 An associate scientist position is open in a global biotech company locating
in MD/DC area. As an Associate Scientist I-II in Pharmacokinetics, you’ll
play a pivotal role in supporting clinical pharmacology project leaders and
team representatives through all stages of a candidate drug's development
cycle. You will be responsible for all aspects of PK-related support for
biotherapeutics-data evaluation, interpretation, and reporting. Specifically
- preparation of toxicokinetic reports, clinical... 阅读全帖 |
|
x**********0
发帖数: 33 | 37 POSITION SUMMARY
A Senior Scientist who will play a key role in new drug characterization and
analysis using LC/MS in research and development. Major responsibilities
include bioanalytical assay development for drug DMPK studies and peptide/
protein and antibody analysis in support of drug candidate selection,
preclinical and IND-enabling studies
ESSENTIAL FUNCTIONS
- Peptide/protein and antibody analysis using Agilent QTOF
- Developing in vitro DMPK assays using SCIEX QTRAP including meta... 阅读全帖 |
|
j******8
发帖数: 12 | 38 We are working with a top Multinational Pharmacy Company to recruit Clinical
Pharmacologist for their R&D center in China (Beijing or Shanghai),
especially in Phase 1/Clinical Pharmacology/PK/PD studies and Clinical
Pharmacology strategy. This position belongs to Early Research Development
Department.
Primary Responsibilities:
• Both build new and apply known disease and drug models as stated
previously. This will be based on clinical trial information inside Roche as
well as the litera... 阅读全帖 |
|
h******e
发帖数: 1791 | 39 pk is generally handled by pk scientists who have phd from pharmacology,
clinical pharmacology, pharmacokinetics, pharmaceutical science........and
use nonmem, winnonlin or r. |
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n******e
发帖数: 476 | 40 赞！他们还用 R 啊，我见过的好像都用 winnonlin, 不过我对他们工作也不熟了。感觉他们也是半个 stat 啊，感觉好多非 stat 专业的都懂一些 stat，真是有压力啊 |
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l****a
发帖数: 352 | 41 Winnonlin is used for individual pk and nonmem/r are for pop-pk.
A lot of stat phd are doing pk in big pharms. it does involve pharmacology
ADME but the nonlinear mixed effect modeling do require stat backgroud.
感觉他们也是半个 stat 啊，感觉好多非 stat 专业的都懂一些 stat，真是有压力啊 |
|
