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c**i 发帖数: 6973 | 3 Nicholas Wade, Scientists Solve Puzzle of Black Death DNA; The genome of an
ancient pathogen has been reconstructed. New York Times, Oct 13, 2011
http://www.nytimes.com/2011/10/13/science
/13plague.html?scp=1&sq=black%20death&st=cse
Note: The report is based on
Bos KI et al, A draft genome of Yersinia pestis from victims of the Black
Death. Nature, published online Oct 12, 2011
http://www.nature.com/nature/journal
/vaop/ncurrent/full/nature10549.html
("Here we report a reconstructed ancient geno... 阅读全帖 |
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l******g 发帖数: 278 | 4 NBME form 4
1. A 22-year-old woman with asthma comes to the physician for a follow-up
examination. She feels well. She has been treated for six acute episodes of
wheezing and nonproductive cough during the past year; her last episode was
1 month ago. Her symptoms are exacerbated when she is outside during the
spring and fall. Current medications include an albuterol inhaler and
echinacea. She has smoked one-half pack of cigarettes daily for 5 years and
does not drink alcohol. She is employed in ... 阅读全帖 |
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g***j 发帖数: 40861 | 5 69%猪肉含耶氏杆菌
According to the study, 69% of pork chops and ground pork samples tested
positive for Yersinia enterocolitica, a bug known to cause infections in
about 100,000 Americans a year, especially kids. |
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X****i 发帖数: 1877 | 6
米国西医给肠胃不适病人 Broad Spectrum 抗生素。
肠胃有益菌全死光了,然后Clostridium,Yersinia就来了。
这些菌都非常顽强难治愈,于是西医就常要求病人验屎。
病人变摇钱树,西医,药铺,提供验屎服务的,皆大欢喜。
米国花街金融业,医疗业,保险业,天天对米国人插管吸血。
多数米国人从不疑有诈,积蓄和养命钱被暴利“服务业”抽干。
国内如以后也学米国的暴利“服务业”,民必穷化,国必衰亡。 |
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发帖数: 1 | 7 不是,还有纪录片说是外星人为了惩罚人类做出来的,很神秘的出来,有很神秘的消失
“根據历史学家巴尼·斯隆(Barney Sloane)的说法,黑死病的致病源頭並非一般所
認為的鼠疫耶尔森氏菌(Yersinia pestis),他舉出幾個例子以支持他的說法[12][13
]:
老鼠也会感染淋巴腺鼠疫而亡,但他表示从14世纪的历史资料上看,并未发现有大量的
鼠类骸骨存在。
據流行病學統計,腺鼠疫的感染個案應隨著冬季來臨逐漸減少,這是由於老鼠及跳蚤对
寒冷的气候较为敏感,數量呈现季节性减少。不過研究表明在公元1348年的英國,黑死
病传播速度在冬天大幅加快,顯示黑死病的致病源並非一般所認為的鼠疫桿菌,而是一
種未知的致病源。(註:冬天傳播更快、可能是人的接觸增加所致。無需再由鼠傳播。
所以上述立論難成立)” |
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b********g 发帖数: 2156 | 8 CCR5-D32,基因突变造成的,并不是应对hiv的基因进化。这种基因突变造成细胞膜表面
receptor损伤。原本是不好的事情,却恰巧损害到hiv的binding site,因为病毒都是
bind在特定的receptor上才能进入host cell,所以hiv就不能攻击了。目前的理论是说,
这种基因突变是variola virus,造成smallpox的病毒引起的。
Up to 20% of ethnic western Europeans carry this mutation, which is rare or
absent in other ethnic groups.9–11 This suggests that the CCR5-delta32
mutation was strongly selected for sometime during European history. Some
researchers have proposed that the plague epidemics that repeatedly swept
Europe during the M... 阅读全帖 |
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d***y 发帖数: 1850 | 9 你要什么菌什么基因啊?
除了ecoli,我们这里还有yersinia pestis 的collection
其他的就不清楚了 |
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发帖数: 1 | 10 #注明译者,请随便转载:)
CRISPR英雄谱
埃里克・兰德(Eric Lander)
小鹿/译
三年之前,科学家们宣布,CRISPR技术能够对真核活细胞进行精准与有效的基因组编辑
。自此,这项技术手段已然震撼了科学界,数以千计的实验室正在将其运用于从生物医
药到农业的各个领域。然而,从一种奇特的细菌重复序列现象的发现开始,到确认这种
现象为适应性免疫系统,进而对它的生物功能特性的了解,直至开发为一项基因工程的
技术,这此前二十载相关的研究历程却不为人所知。本文正是着眼于填补这段科学历史
的空白,它讲述的是观念的演化历史和先锋人物的传奇故事,并且从中获得关于支撑科
学发现的优秀科研环境的启迪。
前言
很难想起曾经有哪一次科学革命像CRISPR这般如此迅速地改变生物学界。仅仅三年之前
,科学家宣布,CRISPR系统,即细菌通过纪录和精准攻击入侵病毒的DNA序列而进行自
身防御的适应性免疫系统,可以利用转化为一项简单而有效的技术在哺乳动物和其它生
物体的活体细胞内进行基因组编辑。CRISPR即此被全球数以千计的实验室运用于广泛的
领域,如创建人类遗传疾病和癌症的复杂动物模型;... 阅读全帖 |
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b*****y 发帖数: 122 | 11 A Postdoctoral Research Fellow position is available in the Department of
Immunology & Microbial Diseases at Albany Medical College. We are looking
for a highly motivated, recently graduated PhD in Microbiology, Immunology
or related area to study bacteria-host interactions and vaccine development.
Currently, the focus of the lab is to investigate Yersinia pestis and Y.
pseudotuberculosis pathogenesis, vaccine development and immune responses
induced by these vaccines.
Qualifications
A PhD in Mi... 阅读全帖 |
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b*****y 发帖数: 122 | 12 A Postdoctoral Research Fellow position is available in the Department of
Immunology & Microbial Diseases at Albany Medical College https://www.amc.
edu/research/IMD/IMD-Faculty.cfm). We are looking for a highly motivated,
recently graduated PhD in Microbiology, Immunology or related area to study
bacteria-host interactions and vaccine development. Currently, the focus of
the lab is to investigate Yersinia pestis and Y. pseudotuberculosis
pathogenesis, vaccine development and immune responses i... 阅读全帖 |
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k*****e 发帖数: 372 | 13 我也跟个BUG原创的bloody diarrhea KJ:
一碗沙砾,大肠艰难啊~
一:耶尔森菌(Yersinia)
碗:空场弯曲菌
沙:沙门菌
粒:痢疾,志贺菌
大肠:E.Coli
艰难:艰难芽胞梭菌(C.difficile)
啊:阿米巴~ |
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s*******g 发帖数: 115 | 14 超强,出来冒个小泡泡小小答谢则个。
热闹过后,也感受一下底层人的生活状态吧:
Shigella,Yersinia特点为不动,不产生H2S。 记为
乞丐见老鼠,不动不生气 |
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s*******g 发帖数: 115 | 15 超强,出来冒个小泡泡小小答谢则个。
热闹过后,也感受一下底层人的生活状态吧:
Shigella,Yersinia特点为不动,不产生H2S。 记为
乞丐见老鼠,不动不生气 |
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z******8 发帖数: 844 | 16 ☆─────────────────────────────────────☆
zhu84518 (Henry) 于 (Mon May 5 23:08:37 2014, 美东) 提到:
一个好的口诀胜读10遍书,记住的知识点那是经久不忘,真是受益匪浅。我和Jeff一起
学习的时候编了不少好的口诀,现在Jeff考试考完了,match完了,抽点时间和我一起
把我们之前的口诀总结出来,一来是奉献麦地,也希望能够帮助后来的同学,二来是防
止我们的口诀继续在那里吃灰,这可都是我们耗费了多少脑细胞的成果。我们打算每天
抽点时间把口诀贴到此贴,如果有同学有自己的口诀想要分享,欢迎跟帖!
☆─────────────────────────────────────☆
zhu84518 (Henry) 于 (Mon May 5 23:12:40 2014, 美东) 提到:
☆─────────────────────────────────────☆
zhu84518 (Henry) 于 (Mon May 5 23:19:23 2014, 美东) 提到:
Toxopl... 阅读全帖 |
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A*******s 发帖数: 9638 | 17 Besides Dengue,bacteria such as Salmonella, Shigella, Yersinia or
Campylobacter, may also cause dysentery and reactive arthritis.
Some STDs should be considered as well. |
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