f***4
发帖数: 886 | 1 一直想做早期Chordate神经系统的发育进化。。。 |
f**u
发帖数: 346 | 2 你喜欢Evo-Devo?为什么选早期chordate的神经系统？你觉得做这个有什么重大意义？
【在 f***4 的大作中提到】
: 一直想做早期Chordate神经系统的发育进化。。。
|
f***4
发帖数: 886 | 3 当然了；高级神经系统的几个重要组成部分（细胞/组织水平）是从哪里来的？不是很
清楚啊。
到鱼这个层次已经很接近哺乳动物了；中间这部分重要时期的研究是缺失的。
你做fugu啊？
【在 f**u 的大作中提到】
: 你喜欢Evo-Devo?为什么选早期chordate的神经系统？你觉得做这个有什么重大意义？
|
f***4
发帖数: 886 | 4 fugu也好啊，只是回答的问题不一样；
听Sydney Brenner自己说，他在 woods hole的图书馆查了一阵资料，最后选了fugu；
可惜没人支持，最后新加坡支持了。。。
他们现在也做软骨鱼。
【在 f**u 的大作中提到】
: 你喜欢Evo-Devo?为什么选早期chordate的神经系统？你觉得做这个有什么重大意义？
|
p*******r
发帖数: 4048 | 5 I am very interested in this stuff.
【在 f***4 的大作中提到】
: 一直想做早期Chordate神经系统的发育进化。。。
|
p*******r
发帖数: 4048 | 6 the main problem is there are very few extant species.
How do you plan to do it?
【在 f***4 的大作中提到】
: 当然了；高级神经系统的几个重要组成部分（细胞/组织水平）是从哪里来的？不是很
: 清楚啊。
: 到鱼这个层次已经很接近哺乳动物了；中间这部分重要时期的研究是缺失的。
: 你做fugu啊？
|
f***4
发帖数: 886 | 7 现在还是梦想啊；
先找到几个能提供标本的地方再说；
现在最基本的知识方法也不是很成熟；
海鞘，七腮鳗，电鳐；想起大学在北戴河海边实习的时候。。
呵呵，问题是没人会支持的
【在 p*******r 的大作中提到】
: the main problem is there are very few extant species.
: How do you plan to do it?
|
f**u
发帖数: 346 | 8 真不好意思，我不做那个。
当时申请ID的时候糊里糊涂想了这么个名字，后来才知道还真有生物学意义。
我觉得你要做这个最重要的是要找到合适的物种来做，感觉挺不容易的。
【在 f***4 的大作中提到】
: 当然了；高级神经系统的几个重要组成部分（细胞/组织水平）是从哪里来的？不是很
: 清楚啊。
: 到鱼这个层次已经很接近哺乳动物了；中间这部分重要时期的研究是缺失的。
: 你做fugu啊？
|
g**********t
发帖数: 475 | 9 我支持你楼主，你想做的是生物学里面最重要的那一类问题，要能做出来那就是一代学
术泰斗。不过这个问题是很难的，有没有想过做别的成熟一点的系统？ |
p*******r
发帖数: 4048 | 10 I am very interested in this direction.
【在 f***4 的大作中提到】
: 现在还是梦想啊；
: 先找到几个能提供标本的地方再说；
: 现在最基本的知识方法也不是很成熟；
: 海鞘，七腮鳗，电鳐；想起大学在北戴河海边实习的时候。。
: 呵呵，问题是没人会支持的
|
|
|
p*******r
发帖数: 4048 | 11 I actually had an idea. I wanted to reconstruct the ancient genome from
extent species, then I want to synthesize a new animal which should be
similar to ancient species.
【在 f***4 的大作中提到】
: 现在还是梦想啊；
: 先找到几个能提供标本的地方再说；
: 现在最基本的知识方法也不是很成熟；
: 海鞘，七腮鳗，电鳐；想起大学在北戴河海边实习的时候。。
: 呵呵，问题是没人会支持的
|
b******n
发帖数: 4225 | 12 我一直也有这种想法
澳大利亚对袋狼的实验没成功
也许用西伯利亚永久冻土的猛犸象有这个可能？
毕竟现代大象可能作为孕体
【在 p*******r 的大作中提到】
: I actually had an idea. I wanted to reconstruct the ancient genome from
: extent species, then I want to synthesize a new animal which should be
: similar to ancient species.
|
p*******r
发帖数: 4048 | 13 I am more interested in resurrecting nearthedals. :)
【在 b******n 的大作中提到】
: 我一直也有这种想法
: 澳大利亚对袋狼的实验没成功
: 也许用西伯利亚永久冻土的猛犸象有这个可能？
: 毕竟现代大象可能作为孕体
|
f**u
发帖数: 346 | 14 嗬嗬，说一个我的类似的想法。
我梦想着有一天可以把mouse通过one mutation at a time一步一步变成rat。
也不一定非要是mouse和rat，也可以是其他相近的物种。
这个肯定是有办法的，至少有一条路，
就是先通过devolution把mouse变成mouse和rat的last common ancester，
然后再从这个ancester通过evolution变成rat。
这条路是进化当中真正发生过的，我也最希望能够重现这样一条路，
但是也许人们永远无法知道这是怎样一条路。
做这个东西并不仅仅是要通过一个一个突变把mouse genome变成rat genome,
那样仅仅是个体力活，这个想法的精髓在于，这个漫长的过程的每一步当中的个体，
都必须有一定的selective advantage，起码不能有disadvantage，
否则就不能在自然界当中真正存在。这一条就带来了非常多的constraints。
【在 p*******r 的大作中提到】
: I actually had an idea. I wanted to reconstruct the ancient genome from
: extent species, then I want to synthesize a new animal which should be
: similar to ancient species.
|
f**u
发帖数: 346 | 15 嗬嗬，你说直接synthesize一个genome，我的理解是design一个新的物种，
个人认为应当从简单的细菌甚至病毒开始，直接作animal难度太大了。
【在 p*******r 的大作中提到】
: I actually had an idea. I wanted to reconstruct the ancient genome from
: extent species, then I want to synthesize a new animal which should be
: similar to ancient species.
|
f**u
发帖数: 346 | 16 以前韩国人黄禹锡不是号称克隆出猛犸了吗。我觉得这个从科学上是有可能的。
但这个不是reconstruct genome，而仅仅是克隆。
另外本人比较完美主义，我希望有办法还原真正的猛犸，
而不是猛犸的核DNA加现代大象的线粒体DNA。
各位有想法能实现这个吗？
【在 b******n 的大作中提到】
: 我一直也有这种想法
: 澳大利亚对袋狼的实验没成功
: 也许用西伯利亚永久冻土的猛犸象有这个可能？
: 毕竟现代大象可能作为孕体
|
p*******r
发帖数: 4048 | 17 I don't see why you can't sequence 线粒体 DNA too.
【在 f**u 的大作中提到】
: 以前韩国人黄禹锡不是号称克隆出猛犸了吗。我觉得这个从科学上是有可能的。
: 但这个不是reconstruct genome，而仅仅是克隆。
: 另外本人比较完美主义，我希望有办法还原真正的猛犸，
: 而不是猛犸的核DNA加现代大象的线粒体DNA。
: 各位有想法能实现这个吗？
|
p*******r
发帖数: 4048 | 18 Of course, long term dream...
Really long term dream is to synthesize next generation human. :)
I want to figure out a kind of human that could live forever.
【在 f**u 的大作中提到】
: 嗬嗬，你说直接synthesize一个genome，我的理解是design一个新的物种，
: 个人认为应当从简单的细菌甚至病毒开始，直接作animal难度太大了。
|
a********k
发帖数: 2273 | 19 去中国搞个文昌鱼的中心吧，清华的深圳研院或者厦门大学都应该挺好搞的。
【在 p*******r 的大作中提到】
: I am very interested in this direction.
|
a********k
发帖数: 2273 | 20 反正现在细菌的genome数据无数，抓些代谢相近的物种算一下ancient的基因序列，做
个全合成然后用venter同学的全基因组转化替代最相似的一个物种的基因组。。。不知
道成功概率多大。
【在 p*******r 的大作中提到】
: I actually had an idea. I wanted to reconstruct the ancient genome from
: extent species, then I want to synthesize a new animal which should be
: similar to ancient species.
|
|
|
p*******r
发帖数: 4048 | 21 There is already one.
【在 a********k 的大作中提到】
: 去中国搞个文昌鱼的中心吧，清华的深圳研院或者厦门大学都应该挺好搞的。
|
p*******r
发帖数: 4048 | 22 Actually the person who told me to do this stuff was James Watson.
He said, if you solve this, you will get a Nobel prize.
【在 a********k 的大作中提到】
: 去中国搞个文昌鱼的中心吧，清华的深圳研院或者厦门大学都应该挺好搞的。
|
a********k
发帖数: 2273 | 23 你是scifi里面的负面典型。
【在 p*******r 的大作中提到】
: Of course, long term dream...
: Really long term dream is to synthesize next generation human. :)
: I want to figure out a kind of human that could live forever.
|
p*******r
发帖数: 4048 | 24 That was a joke of course. hehe.
【在 a********k 的大作中提到】
: 你是scifi里面的负面典型。
|
a********k
发帖数: 2273 | 25 Actually, there are lots of people thinking about using lancelet as a model
to figure out something. The real question is what is the best/most
interesting question to use this model. You cannot just jump into this and
do something like neural development, genetic screening. You may have a
chance to get luck but it is not some Nobel dynamite. There are quite a few
people in Germany and China doing lancelet, but are they going to win a
Nobel?
【在 p*******r 的大作中提到】
: Actually the person who told me to do this stuff was James Watson.
: He said, if you solve this, you will get a Nobel prize.
|
p*******r
发帖数: 4048 | 26 The details of my plan will be revealed in my Nobel speech. :)
Just kidding of course.
model
and
few
【在 a********k 的大作中提到】
: Actually, there are lots of people thinking about using lancelet as a model
: to figure out something. The real question is what is the best/most
: interesting question to use this model. You cannot just jump into this and
: do something like neural development, genetic screening. You may have a
: chance to get luck but it is not some Nobel dynamite. There are quite a few
: people in Germany and China doing lancelet, but are they going to win a
: Nobel?
|
d*****r
发帖数: 2583 | 27 你只要解决了cognition或者memory的问题，基本上离永远不死就很接近了。
【在 p*******r 的大作中提到】
: Of course, long term dream...
: Really long term dream is to synthesize next generation human. :)
: I want to figure out a kind of human that could live forever.
|
a********k
发帖数: 2273 | 28 I tend to believe this.... :)
【在 p*******r 的大作中提到】
: The details of my plan will be revealed in my Nobel speech. :)
: Just kidding of course.
:
: model
: and
: few
|
p*******r
发帖数: 4048 | 29 Yeah I have five main passions at this point:
1 How does neural system compute? From this insight, I can build
artificial intelligence.
2 How is memory encoded in the brain? If I figure out this, I can build a
brain computer interface to have very good memory.
3 How is nervous system evolved? From this, I can build next generation
human.
4 What is the fundamental code of emotion? This has social implications.
5 How does nervous interact with the body? I think this is related to
spiritual healing
【在 d*****r 的大作中提到】
: 你只要解决了cognition或者memory的问题，基本上离永远不死就很接近了。
|
f***4
发帖数: 886 | 30 比如neural crest的出现。。。
其实我最感兴趣的还是圆口纲。比如颌的形成；
model
few
【在 a********k 的大作中提到】
: Actually, there are lots of people thinking about using lancelet as a model
: to figure out something. The real question is what is the best/most
: interesting question to use this model. You cannot just jump into this and
: do something like neural development, genetic screening. You may have a
: chance to get luck but it is not some Nobel dynamite. There are quite a few
: people in Germany and China doing lancelet, but are they going to win a
: Nobel?
|
|
|
d*****r
发帖数: 2583 | 31 6 How to transfer Cognition/Memory from one substrate(Biochem) to
another substrate (Silicon?) ? From this insight, I can make myself
alive-forever...
【在 p*******r 的大作中提到】
: Yeah I have five main passions at this point:
: 1 How does neural system compute? From this insight, I can build
: artificial intelligence.
: 2 How is memory encoded in the brain? If I figure out this, I can build a
: brain computer interface to have very good memory.
: 3 How is nervous system evolved? From this, I can build next generation
: human.
: 4 What is the fundamental code of emotion? This has social implications.
: 5 How does nervous interact with the body? I think this is related to
: spiritual healing
|
f***4
发帖数: 886 | 32 老牛啊；呵呵；敬仰。。。
【在 p*******r 的大作中提到】
: Yeah I have five main passions at this point:
: 1 How does neural system compute? From this insight, I can build
: artificial intelligence.
: 2 How is memory encoded in the brain? If I figure out this, I can build a
: brain computer interface to have very good memory.
: 3 How is nervous system evolved? From this, I can build next generation
: human.
: 4 What is the fundamental code of emotion? This has social implications.
: 5 How does nervous interact with the body? I think this is related to
: spiritual healing
|
d*****r
发帖数: 2583 | 33 解决每一个问题都可以出来100个诺贝尔奖。。
【在 p*******r 的大作中提到】
: Yeah I have five main passions at this point:
: 1 How does neural system compute? From this insight, I can build
: artificial intelligence.
: 2 How is memory encoded in the brain? If I figure out this, I can build a
: brain computer interface to have very good memory.
: 3 How is nervous system evolved? From this, I can build next generation
: human.
: 4 What is the fundamental code of emotion? This has social implications.
: 5 How does nervous interact with the body? I think this is related to
: spiritual healing
|
p*******r
发帖数: 4048 | 34 I leave that problem to my grad students. Hehe. :)
【在 d*****r 的大作中提到】
: 6 How to transfer Cognition/Memory from one substrate(Biochem) to
: another substrate (Silicon?) ? From this insight, I can make myself
: alive-forever...
|
p*******r
发帖数: 4048 | 35 I am just dreaming/joking of course...
【在 f***4 的大作中提到】
: 老牛啊；呵呵；敬仰。。。
|
d*****r
发帖数: 2583 | 36 my ex-advisor and his advisor spent whole life trying to solve it;
I thought they are too smart, so I quit from this direction...
so sad..
【在 p*******r 的大作中提到】
: I leave that problem to my grad students. Hehe. :)
|
d*****r
发帖数: 2583 | 37 大年夜鼓励白日梦，:)
【在 p*******r 的大作中提到】
: I am just dreaming/joking of course...
|
d*****r
发帖数: 2583 | 38 好的，以后我去你的实验室度假就做这个。。
【在 p*******r 的大作中提到】
: I leave that problem to my grad students. Hehe. :)
|
n********k
发帖数: 2818 | 39 there are people doing along all the directions right now, right? I am very
much interested in the last one, and i think that might be a most
approachable...of course I am a molecular/cellular/developmental guy....
others I think it is cmpletely a mess now and do we have any idea even what
we are studying?
【在 p*******r 的大作中提到】
: Yeah I have five main passions at this point:
: 1 How does neural system compute? From this insight, I can build
: artificial intelligence.
: 2 How is memory encoded in the brain? If I figure out this, I can build a
: brain computer interface to have very good memory.
: 3 How is nervous system evolved? From this, I can build next generation
: human.
: 4 What is the fundamental code of emotion? This has social implications.
: 5 How does nervous interact with the body? I think this is related to
: spiritual healing
|
a********k
发帖数: 2273 | 40 我对于neural crest和notochord都挺感兴趣，至于两者之间的，我觉得个人智商有限
。。。
【在 f***4 的大作中提到】
: 比如neural crest的出现。。。
: 其实我最感兴趣的还是圆口纲。比如颌的形成；
:
: model
: few
|
|
|
p*******r
发帖数: 4048 | 41 You are welcome to spend some vacation time in my lab to work on that
direction. :)
very
what
【在 n********k 的大作中提到】
: there are people doing along all the directions right now, right? I am very
: much interested in the last one, and i think that might be a most
: approachable...of course I am a molecular/cellular/developmental guy....
: others I think it is cmpletely a mess now and do we have any idea even what
: we are studying?
|
f**u
发帖数: 346 | 42 测序当然容易了，但是你怎么替换？
我的理解是克隆猛犸要用现代大象的卵子吧？
还是你觉得可以用iPS的方法去克隆？
【在 p*******r 的大作中提到】
: I don't see why you can't sequence 线粒体 DNA too.
|
p*******r
发帖数: 4048 | 43 iPS is fine.
【在 f**u 的大作中提到】
: 测序当然容易了，但是你怎么替换？
: 我的理解是克隆猛犸要用现代大象的卵子吧？
: 还是你觉得可以用iPS的方法去克隆？
|
f**u
发帖数: 346 | 44 我觉得做这些难度挺大的，可能还是做做昆虫翅膀怎么出来的比较容易。
从生物学本质上来说这些都是在做新的form是怎样进化出来的，但是难易还是有别的。
不过我承认，做notochord这类的比做翅膀有趣。
【在 a********k 的大作中提到】
: 我对于neural crest和notochord都挺感兴趣，至于两者之间的，我觉得个人智商有限
: 。。。
|
r****r
发帖数: 379 | 45 I am working the 5th question in worms......
也是基于中医里的概念，我一直在想研究每个系统之间的相互关系，然后发现用虫子做这个多快好省。现在越来越发现，这里面大有文章，甚至连一些经典的认为是细胞内决定的生物学事件都受到其它系统的影响。
so far, we have some data about how nervous, gut and hypodermal system interact with reproductive system to control the body`s response to some kinds of stress.
【在 p*******r 的大作中提到】
: Yeah I have five main passions at this point:
: 1 How does neural system compute? From this insight, I can build
: artificial intelligence.
: 2 How is memory encoded in the brain? If I figure out this, I can build a
: brain computer interface to have very good memory.
: 3 How is nervous system evolved? From this, I can build next generation
: human.
: 4 What is the fundamental code of emotion? This has social implications.
: 5 How does nervous interact with the body? I think this is related to
: spiritual healing
|
r****r
发帖数: 379 | 46 one of my friends is trying to launch a company based on the concept of
storing memory, hehe
【在 d*****r 的大作中提到】
: my ex-advisor and his advisor spent whole life trying to solve it;
: I thought they are too smart, so I quit from this direction...
: so sad..
|
l*******1
发帖数: 128 | 47 Great post.
I've got only one and I'm now working on it:
What's sleep? And what's the function of sleep?
【在 p*******r 的大作中提到】
: Yeah I have five main passions at this point:
: 1 How does neural system compute? From this insight, I can build
: artificial intelligence.
: 2 How is memory encoded in the brain? If I figure out this, I can build a
: brain computer interface to have very good memory.
: 3 How is nervous system evolved? From this, I can build next generation
: human.
: 4 What is the fundamental code of emotion? This has social implications.
: 5 How does nervous interact with the body? I think this is related to
: spiritual healing
|
p*******r
发帖数: 4048 | 48 I'd rather get rid of it. ^_^
【在 l*******1 的大作中提到】
: Great post.
: I've got only one and I'm now working on it:
: What's sleep? And what's the function of sleep?
|
l*******1
发帖数: 128 | 49 Very true. 可是进化说“这个一定要有”。而我们不知道为什么？
【在 p*******r 的大作中提到】
: I'd rather get rid of it. ^_^
|
p*******r
发帖数: 4048 | 50 可能是没发明电灯的原因。
【在 l*******1 的大作中提到】
: Very true. 可是进化说“这个一定要有”。而我们不知道为什么？
|
