N**D 发帖数: 2885 | 1 【 以下文字转载自 WaterWorld 讨论区 】
发信人: NYPD (New York, Pursuit of Dream), 信区: WaterWorld
标 题: Antibody Kills 91% of HIV Strains
发信站: BBS 未名空间站 (Thu Jul 8 16:02:53 2010, 美东)
from wsj
In a significant step toward an AIDS vaccine, U.S. government scientists
have discovered three powerful antibodies, the strongest of which
neutralizes 91% of HIV strains, more than any AIDS antibody yet discovered.
Looking closely at the strongest antibody, they have detailed exactly what
part of the virus it targets and |
N**D 发帖数: 2885 | 2 重大突破啊同学们!
【在 N**D 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 【 以下文字转载自 WaterWorld 讨论区 】 : 发信人: NYPD (New York, Pursuit of Dream), 信区: WaterWorld : 标 题: Antibody Kills 91% of HIV Strains : 发信站: BBS 未名空间站 (Thu Jul 8 16:02:53 2010, 美东) : from wsj : In a significant step toward an AIDS vaccine, U.S. government scientists : have discovered three powerful antibodies, the strongest of which : neutralizes 91% of HIV strains, more than any AIDS antibody yet discovered. : Looking closely at the strongest antibody, they have detailed exactly what : part of the virus it targets and
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a***a 发帖数: 40617 | 3 最后一句很汗
【在 N**D 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 重大突破啊同学们!
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y*****1 发帖数: 73 | |
s******y 发帖数: 28562 | 5 I just read this on my cellphone.
It is likely an antibody against a conserved region of the virus.
Such a concept exists for a long time but I am suprised it took so
long to produce something like that for HIV
【在 N**D 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 重大突破啊同学们!
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a***a 发帖数: 40617 | 6 之前还有个号称治aids的发了nature biotechnology,不知道是不是就是这个
【在 s******y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : I just read this on my cellphone. : It is likely an antibody against a conserved region of the virus. : Such a concept exists for a long time but I am suprised it took so : long to produce something like that for HIV
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s******y 发帖数: 28562 | 7 Actually it is not that difficult as we may think
For example we can figure out the binding pocket of the antibody and then
either make it a monoclonal mini-antibody for injection or make the DNA
for generation of such a antibody and clone it into our bone marrow stem
cells
【在 a***a 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 最后一句很汗
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a***a 发帖数: 40617 | 8 单抗可行,第二个基本现阶段是扯,是科幻小说
【在 s******y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : Actually it is not that difficult as we may think : For example we can figure out the binding pocket of the antibody and then : either make it a monoclonal mini-antibody for injection or make the DNA : for generation of such a antibody and clone it into our bone marrow stem : cells
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h********n 发帖数: 4079 | 9 最后一段都很汗.
【在 a***a 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 最后一句很汗
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s******y 发帖数: 28562 | 10 How come? Such thing can be done in vitro in a rather straight forward way.
Can we transfect the donor bone marrow cells and then go for immuno
stimulate
and selection and finally select for the memory B cell that express that
particular antibody and put it back to the donor's body?
I mean there will be a lot of work invovled but in theory that should be
doable
right?
【在 a***a 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 单抗可行,第二个基本现阶段是扯,是科幻小说
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a***a 发帖数: 40617 | 11 thousands of things can be done in vitro.BUT....
【在 s******y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : How come? Such thing can be done in vitro in a rather straight forward way. : Can we transfect the donor bone marrow cells and then go for immuno : stimulate : and selection and finally select for the memory B cell that express that : particular antibody and put it back to the donor's body? : I mean there will be a lot of work invovled but in theory that should be : doable : right?
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p*****m 发帖数: 7030 | 12 其实都用不了这么麻烦 直接在造血干细胞里面突变掉CCR5然后原封不动的给患者注射回
去就行了 也不需要考虑哪个antibody好用 呵呵
其实拿bone marrow cell出来转了基因然后种回去已经做了n个临床实验了 效果不好说
但是至少是feasible的
【在 s******y 的大作中提到】![](/moin_static193/solenoid/img/up.png) : How come? Such thing can be done in vitro in a rather straight forward way. : Can we transfect the donor bone marrow cells and then go for immuno : stimulate : and selection and finally select for the memory B cell that express that : particular antibody and put it back to the donor's body? : I mean there will be a lot of work invovled but in theory that should be : doable : right?
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K******S 发帖数: 10109 | 13 "Researchers screened 25 million of his cells
to find 12 that produced the antibodies. Now the trick will be for
scientists to develop a vaccine or other methods to make anyone's body
produce them."
now they will keep that man as national treasure.
【在 N**D 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 重大突破啊同学们!
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W****C 发帖数: 1937 | 14 the strongest of which neutralizes 91% of HIV strains,more than any AIDS
antibody yet discovered.
control做得不好, 之前的抗体是90%呢还是1%呢? |
s*****3 发帖数: 41 | 15 I just read this article. It seems pretty good.
In the last figure, they compare the neutralization potency and breadth of
the new antibody VRC01 with that of b12, a well-known broadly neutralizing
Ab against CD4 binding site of gp120. Under IC50 <50 ug/ml, VRC01 can
neutralize 91% of 190 Env pseudoviruses, whereas b12 can only neutralize 41%.
One question about the paper is that they design a molecule, RSC3, that
keeps the antigenicity of CD4 binding site of gp120 whereas remove the
antigenicit |
O******e 发帖数: 4845 | 16 Or you should say: thousands of things were claimed to happen in vitro....
【在 a***a 的大作中提到】![](/moin_static193/solenoid/img/up.png) : thousands of things can be done in vitro.BUT....
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