i***R
发帖数: 663 | 1 Key word: ActRIIB Antagonism, muscle mouse, dramatic prolonged survival,
ubiquitin-proteasome system, Muscle Stem cell
这篇文章很有意思, 肌肉鼠得了癌症后，40天基本不死，对照组基本死光。
doi:10.1016/j.cell.2010.07.011
Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism
Leads to Prolonged Survival
Xiaolan Zhou1, Jin Lin Wang1, John Lu1, Yanping Song1, Keith S. Kwak1,
Qingsheng Jiao1, Robert Rosenfeld1, Qing Chen1, Thomas Boone1, W. Scott
Simonet1, David L. Lacey1, Alfred L. Goldberg2 and H.Q. Han1, ,
1 Departme |
s******y
发帖数: 28562 | 2 Interesting!
That actually means the degradation and apoptosis of the muscle is the lethal factor of cancer!
【在 i***R 的大作中提到】
: Key word: ActRIIB Antagonism, muscle mouse, dramatic prolonged survival,
: ubiquitin-proteasome system, Muscle Stem cell
: 这篇文章很有意思, 肌肉鼠得了癌症后，40天基本不死，对照组基本死光。
: doi:10.1016/j.cell.2010.07.011
: Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism
: Leads to Prolonged Survival
: Xiaolan Zhou1, Jin Lin Wang1, John Lu1, Yanping Song1, Keith S. Kwak1,
: Qingsheng Jiao1, Robert Rosenfeld1, Qing Chen1, Thomas Boone1, W. Scott
: Simonet1, David L. Lacey1, Alfred L. Goldberg2 and H.Q. Han1, ,
: 1 Departme
|
i***R
发帖数: 663 | 3 我估计肌肉细胞可以把癌细胞挤死，防止癌细胞扩散，呵呵。 |
s******y
发帖数: 28562 | 4 No...That's not what the paper means :) At least not what the authors think.
【在 i***R 的大作中提到】
: 我估计肌肉细胞可以把癌细胞挤死，防止癌细胞扩散，呵呵。
|
i***R
发帖数: 663 | 5 我这个借用是李大师，张大师的思维。
think.
【在 s******y 的大作中提到】
: No...That's not what the paper means :) At least not what the authors think.
|
i***R
发帖数: 663 | 6 癌症让心脏变小这个很有趣。
癌症病人有的知道了以后吓得要死，吃也吃不下，睡也睡不着。就加速了肌肉的猥琐。
以后的事就是意料之中的。
think.
【在 s******y 的大作中提到】
: No...That's not what the paper means :) At least not what the authors think.
|
i***R
发帖数: 663 | 7 不知道癌症是否可以用中医治疗痿症的方法治疗。虽然不能直接杀灭癌细胞，但可以增
强机体功能，抵
抗癌症。
lethal factor of cancer!
【在 s******y 的大作中提到】
: Interesting!
: That actually means the degradation and apoptosis of the muscle is the lethal factor of cancer!
|
h****g
发帖数: 439 | 8 临床上，大部分肿瘤病人最后是死于肿瘤引起的恶病质,Cachexia，而不是肿瘤本身。这篇文章就是找到了一个target，减轻恶病质症状，提高生存率。
这篇文章思路很新颖（至少对我来说），有巨大的临床应用前景。 |
i***R
发帖数: 663 | 9 是呀，通讯作者童鞋已经投身 Amgen 了
【在 h****g 的大作中提到】
: 临床上，大部分肿瘤病人最后是死于肿瘤引起的恶病质,Cachexia，而不是肿瘤本身。这篇文章就是找到了一个target，减轻恶病质症状，提高生存率。
: 这篇文章思路很新颖（至少对我来说），有巨大的临床应用前景。
|
s******y
发帖数: 28562 | 10 Yes. I am so very sure they will soon jump into the clinical trial
。这篇文章就是找到了一个target，减轻恶病质症状，提高生存率。
【在 h****g 的大作中提到】
: 临床上，大部分肿瘤病人最后是死于肿瘤引起的恶病质,Cachexia，而不是肿瘤本身。这篇文章就是找到了一个target，减轻恶病质症状，提高生存率。
: 这篇文章思路很新颖（至少对我来说），有巨大的临床应用前景。
|
|
|
s******y
发帖数: 28562 | 11 I think many 中医 are using that logic.
【在 i***R 的大作中提到】
: 不知道癌症是否可以用中医治疗痿症的方法治疗。虽然不能直接杀灭癌细胞，但可以增
: 强机体功能，抵
: 抗癌症。
:
: lethal factor of cancer!
|
n********k
发帖数: 2818 | 12 This thread showcases:))) how far we(even including our know-all sunny:)))
are from clinics....cancer cachexia
is one of major problems in AIDS, cancer and aging patient and their life
quality etc etc, are very well known in
clinical community but seems so remote from us..I happen to know this
because I was working on muscle
development and cell death and my boss tried to link to diseased status and
I was writing up a review on
Autophagy, PCD in muscle development and wasting etc...otherwise I w
【在 s******y 的大作中提到】
: Interesting!
: That actually means the degradation and apoptosis of the muscle is the lethal factor of cancer!
|
s******y
发帖数: 28562 | 13 I think this was a hypothesis or assumption people had have for a long time
without formal proof for the relationship between cachexia and death.
True, many patients with terminal diseases usually die with symptom of
cachexia. However, is it merely a side result of the dying body? Or is it
part of the pathological cause of death? This "cause" and "effect"
relationship was never vigourously or formally tested.
The reagent used in this study acts directly on muscle without effects on
cancer progre
【在 n********k 的大作中提到】
: This thread showcases:))) how far we(even including our know-all sunny:)))
: are from clinics....cancer cachexia
: is one of major problems in AIDS, cancer and aging patient and their life
: quality etc etc, are very well known in
: clinical community but seems so remote from us..I happen to know this
: because I was working on muscle
: development and cell death and my boss tried to link to diseased status and
: I was writing up a review on
: Autophagy, PCD in muscle development and wasting etc...otherwise I w
|
h****g
发帖数: 439 | 14 这就是“传统生物学”的研究思路害死人啊。不是为了解决临床问题而去研究生命现象
，大部分纯粹是为了研究而研究。
连我这种从临床半路出家学生物的人，被学生物的老师教的，思路越来越脱离临床，越
来越险隘，即使最后能发个CNS文章，估计一点也不能解决临床问题。可悲可叹啊！
and
【在 n********k 的大作中提到】
: This thread showcases:))) how far we(even including our know-all sunny:)))
: are from clinics....cancer cachexia
: is one of major problems in AIDS, cancer and aging patient and their life
: quality etc etc, are very well known in
: clinical community but seems so remote from us..I happen to know this
: because I was working on muscle
: development and cell death and my boss tried to link to diseased status and
: I was writing up a review on
: Autophagy, PCD in muscle development and wasting etc...otherwise I w
|
h****g
发帖数: 439 | 15 这个如果成功，能够延长肿瘤病人带瘤生存时间，绝对是一个超级超级重磅药。适应范围太
广了，几乎任何肿瘤和慢性病。一年几百亿美元绝对没问题。
【在 s******y 的大作中提到】
: Yes. I am so very sure they will soon jump into the clinical trial
:
: 。这篇文章就是找到了一个target，减轻恶病质症状，提高生存率。
|
i***R
发帖数: 663 | 16 You are the expert ! Talk more about this topic pls. :)
Alexandra C. McPherron in UTSW first got DN ActRIIB mouse line years
ago. The phenotype are striking, very muscular mouse indeed.
http://www.pnas.org/content/98/16/9306.full
Maybe this mouse will also resist to AIDS, cancer etc.
sunny:)))
life
status and
would
【在 n********k 的大作中提到】
: This thread showcases:))) how far we(even including our know-all sunny:)))
: are from clinics....cancer cachexia
: is one of major problems in AIDS, cancer and aging patient and their life
: quality etc etc, are very well known in
: clinical community but seems so remote from us..I happen to know this
: because I was working on muscle
: development and cell death and my boss tried to link to diseased status and
: I was writing up a review on
: Autophagy, PCD in muscle development and wasting etc...otherwise I w
|
s******r
发帖数: 2876 | 17 这个思路不错，因为研究生物本来就不是为了治病救人。
这就是“传统生物学”的研究思路害死人啊。不是为了解决临床问题而去研究生命现象
，大部分纯粹是为了研究而研究。
连我这种从临床半路出家学生物的人，被学生物的老师教的，思路越来越脱离临床，越
来越险隘，即使最后能发个CNS文章，估计一点也不能解决临床问题。可悲可叹啊！
and
【在 h****g 的大作中提到】
: 这就是“传统生物学”的研究思路害死人啊。不是为了解决临床问题而去研究生命现象
: ，大部分纯粹是为了研究而研究。
: 连我这种从临床半路出家学生物的人，被学生物的老师教的，思路越来越脱离临床，越
: 来越险隘，即使最后能发个CNS文章，估计一点也不能解决临床问题。可悲可叹啊！
:
: and
|
O******e
发帖数: 4845 | 18 没这么夸张吧。本来要回答的问题都不同，要不然就不用分什么基础和应用了。
【在 h****g 的大作中提到】
: 这就是“传统生物学”的研究思路害死人啊。不是为了解决临床问题而去研究生命现象
: ，大部分纯粹是为了研究而研究。
: 连我这种从临床半路出家学生物的人，被学生物的老师教的，思路越来越脱离临床，越
: 来越险隘，即使最后能发个CNS文章，估计一点也不能解决临床问题。可悲可叹啊！
:
: and
|
O******e
发帖数: 4845 | 19 但生物医学是
【在 s******r 的大作中提到】
: 这个思路不错，因为研究生物本来就不是为了治病救人。
:
: 这就是“传统生物学”的研究思路害死人啊。不是为了解决临床问题而去研究生命现象
: ，大部分纯粹是为了研究而研究。
: 连我这种从临床半路出家学生物的人，被学生物的老师教的，思路越来越脱离临床，越
: 来越险隘，即使最后能发个CNS文章，估计一点也不能解决临床问题。可悲可叹啊！
: and
|
n********k
发帖数: 2818 | 20 not really, I just happen to know a bit....the myostatin is an amazing gene.
..I am just afraid this one is just
another hype like myostatin once was...left the field for ys, don't really
know the state of art now....
【在 i***R 的大作中提到】
: You are the expert ! Talk more about this topic pls. :)
: Alexandra C. McPherron in UTSW first got DN ActRIIB mouse line years
: ago. The phenotype are striking, very muscular mouse indeed.
: http://www.pnas.org/content/98/16/9306.full
: Maybe this mouse will also resist to AIDS, cancer etc.
:
: sunny:)))
: life
: status and
: would
|
|
|
n********k
发帖数: 2818 | 21 the doctors know it(not prove it, one doesn't have to)...the more I research
, the more I think we shall know
more about medicine/clinics if we ever want to contribute directly to human
health...
time
effect
【在 s******y 的大作中提到】
: I think this was a hypothesis or assumption people had have for a long time
: without formal proof for the relationship between cachexia and death.
: True, many patients with terminal diseases usually die with symptom of
: cachexia. However, is it merely a side result of the dying body? Or is it
: part of the pathological cause of death? This "cause" and "effect"
: relationship was never vigourously or formally tested.
: The reagent used in this study acts directly on muscle without effects on
: cancer progre
|
h********n
发帖数: 4079 | 22 let me say it this way: biology and medicine are different subject, people
speak different languages. The more I talk with physician and biologist,
the more I realize this. I think it is very important for biologist to
learn medicine.
BTW, I never consider myself as a biologist. I think I am a scientist
working on cancer.
research
human
【在 n********k 的大作中提到】
: the doctors know it(not prove it, one doesn't have to)...the more I research
: , the more I think we shall know
: more about medicine/clinics if we ever want to contribute directly to human
: health...
:
: time
: effect
|
s******y
发帖数: 28562 | 23 的确，很多临床上的直觉性的认识还没有得到生物学上的证实。
我们要想直接对人类作贡献的话，的确应该多去听听有关的医学讲座，
和医生多聊聊。
不过不幸的是。。。美国的大部分医生自视甚高，一般不太理睬作基础研究的人。
另外，作基础研究的同学们也不要妄自菲薄。要不是基础研究发现了activin receptor
pathway 以及小分子筛选技术，这个研究是做不下去的。
research
human
【在 n********k 的大作中提到】
: the doctors know it(not prove it, one doesn't have to)...the more I research
: , the more I think we shall know
: more about medicine/clinics if we ever want to contribute directly to human
: health...
:
: time
: effect
|
i***R
发帖数: 663 | 24 多数美国医生的确牛鼻红红。我们美国postdoc 也这么认为。 |
O******e
发帖数: 4845 | 25 他们的工作直接关系生死，钱又挣得多，自然牛气了
【在 i***R 的大作中提到】
: 多数美国医生的确牛鼻红红。我们美国postdoc 也这么认为。
|
n********k
发帖数: 2818 | 26 Sure, and more problematic, many PhD PI and Chinese MD or PhD feel the same
way as well, always thinking
MD is such a big deal....I would say what is the heck, big deal...for many,
it is just a choice of career or matter
of interest...
【在 O******e 的大作中提到】
: 他们的工作直接关系生死，钱又挣得多，自然牛气了
|
O******e
发帖数: 4845 | 27 虽然众生平等，但职业的重要性还是区别很大的。一个普通的公车司机和一个医生比，
那显然是医生更重要。
same
,
【在 n********k 的大作中提到】
: Sure, and more problematic, many PhD PI and Chinese MD or PhD feel the same
: way as well, always thinking
: MD is such a big deal....I would say what is the heck, big deal...for many,
: it is just a choice of career or matter
: of interest...
|
