n********k
发帖数: 2818 | 1 but to me, a bit too good/dramatic to be true...I have no doubt the
hypothesis/conclusion likely will stand but
I would think that the dramatic effects resulted from ER in these cancer
models is by far too good from what
many would expect...
Anyway, here is one of most interesting/amazing papers lately
Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis
Causes Cancer Remission and
Inhibition
http://www.cell.com/issue?pii=S0092-8674(10)X0014-9 |
H*********1
发帖数: 56 | 2 I have the same feeling: too good to be true.
i do not know other labs can repeat it or not.
BTW, the first author already got a PI position in NY.
【在 n********k 的大作中提到】
: but to me, a bit too good/dramatic to be true...I have no doubt the
: hypothesis/conclusion likely will stand but
: I would think that the dramatic effects resulted from ER in these cancer
: models is by far too good from what
: many would expect...
: Anyway, here is one of most interesting/amazing papers lately
: Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis
: Causes Cancer Remission and
: Inhibition
: http://www.cell.com/issue?pii=S0092-8674(10)X0014-9
|
b****u
发帖数: 903 | 3 it's very interested paper and i am curious how to set up a ER model for
mice, since the birth day the mice have been raised in cage, more feed, more
clean, or broadcast the Mozart that's the ER?
【在 n********k 的大作中提到】
: but to me, a bit too good/dramatic to be true...I have no doubt the
: hypothesis/conclusion likely will stand but
: I would think that the dramatic effects resulted from ER in these cancer
: models is by far too good from what
: many would expect...
: Anyway, here is one of most interesting/amazing papers lately
: Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis
: Causes Cancer Remission and
: Inhibition
: http://www.cell.com/issue?pii=S0092-8674(10)X0014-9
|
H****N
发帖数: 997 | 4 This is what this board should talk about most of the time. Not in the field
, but since my good friend neverthink recommended it, I will read it. |
n********k
发帖数: 2818 | 5 pretty easy and well practiced in mouse facility and in particular in adult
neurogenesis, and neurobehavior
labs...Yes, people do broadcasting Mozart to mice, I am not kidding...In
fact, the PI of this paper was studing
ER and neurogenesis, I think that's where this paper originated...very much
make sense and likely shall be
practiced more in clinics..., but I couldn't be more stunned with the
cleaniness and linearity of the
data/results...I couldn't wait to repeat this if I had my own lab now..
【在 b****u 的大作中提到】
: it's very interested paper and i am curious how to set up a ER model for
: mice, since the birth day the mice have been raised in cage, more feed, more
: clean, or broadcast the Mozart that's the ER?
|
n********k
发帖数: 2818 | 6 thanks, buddy...have a nice one...
field
【在 H****N 的大作中提到】
: This is what this board should talk about most of the time. Not in the field
: , but since my good friend neverthink recommended it, I will read it.
|
h********n
发帖数: 4079 | 7 really interesting paper. Too good to be true.
I am thinking what if they put some well established cancer mouse model into
their EE cage to test the effect. |
n********k
发帖数: 2818 | 8 talk to ur boss and try it:)))
into
【在 h********n 的大作中提到】
: really interesting paper. Too good to be true.
: I am thinking what if they put some well established cancer mouse model into
: their EE cage to test the effect.
|
b****n
发帖数: 311 | 9 俺有一点negative的comment：
俺们现在的老鼠都是养在小笼子里的，already overfed, too few motor activity(尤
其是rat，mouse还好一点),还有可怕的单调环境。他们的behavior，physiology早就是
不健康的了。几年前，Alzheimer field一个有点名气的group，Sisoda SS lab，发了
一个类似的Cell paper, 讲Enrivoment Enrichment可以reduce Abeta formation, 抑
制Alzheimer disease发生。
Orly Lazarov, John Robinson, Ya-Ping Tang, Ilana S. Hairston, Zeljka Korade-
Mirnics, Virginia M.-Y. Lee, Lou B. Hersh, Robert M. Sapolsky, Karoly
Mirnics and Sangram S. Sisodia (2005) “Environmental Enrichment Reduces A b |
h********n
发帖数: 4079 | 10 for the EE cage, money should not be an issue, but the total cage space will
be huge. The animal facility will not allow us to occupy so much room.
【在 n********k 的大作中提到】
: talk to ur boss and try it:)))
:
: into
|
|
|
s******y
发帖数: 28562 | 11 我觉得这个研究很有启发啊，就类似前一阵子的那个肌肉鼠差不多，就是
从分子角度做生理学。
先由环境来改变生理，然后倒推着找出具体哪个分子途径是被改变了，
然后再从分子水平来证实。
不过，我希望有别人来重复这些文章。这些文章的结果虽然很美妙，但是
有点too good to be true 了。因为从直觉上来说，似乎优厚的生活条件
能改变很多因素，不太可能那么特异的改变一个途径吧？
Korade-
b
【在 b****n 的大作中提到】
: 俺有一点negative的comment：
: 俺们现在的老鼠都是养在小笼子里的，already overfed, too few motor activity(尤
: 其是rat，mouse还好一点),还有可怕的单调环境。他们的behavior，physiology早就是
: 不健康的了。几年前，Alzheimer field一个有点名气的group，Sisoda SS lab，发了
: 一个类似的Cell paper, 讲Enrivoment Enrichment可以reduce Abeta formation, 抑
: 制Alzheimer disease发生。
: Orly Lazarov, John Robinson, Ya-Ping Tang, Ilana S. Hairston, Zeljka Korade-
: Mirnics, Virginia M.-Y. Lee, Lou B. Hersh, Robert M. Sapolsky, Karoly
: Mirnics and Sangram S. Sisodia (2005) “Environmental Enrichment Reduces A b
|
n********k
发帖数: 2818 | 12 the cell paper you talk is a lot easier than this one...BTW I am just
posting this paper for discussion...I am
trying to be critical but have no negative or positive altitude on it...
BTW, For sure, the caging is problematic and that's why fernado(bird song
) from Rockfeller saying cage is a
boring place and he studies wild bird....nonetheless, EE is indeed needed
for human as well, today's word is
not an EE at least for many many people...
Korade-
b
【在 b****n 的大作中提到】
: 俺有一点negative的comment：
: 俺们现在的老鼠都是养在小笼子里的，already overfed, too few motor activity(尤
: 其是rat，mouse还好一点),还有可怕的单调环境。他们的behavior，physiology早就是
: 不健康的了。几年前，Alzheimer field一个有点名气的group，Sisoda SS lab，发了
: 一个类似的Cell paper, 讲Enrivoment Enrichment可以reduce Abeta formation, 抑
: 制Alzheimer disease发生。
: Orly Lazarov, John Robinson, Ya-Ping Tang, Ilana S. Hairston, Zeljka Korade-
: Mirnics, Virginia M.-Y. Lee, Lou B. Hersh, Robert M. Sapolsky, Karoly
: Mirnics and Sangram S. Sisodia (2005) “Environmental Enrichment Reduces A b
|
a******g
发帖数: 129 | 13 You are coaxed by the sexy title.
Our lab reviewed this paper for Cell. Actually, the only sexy part is tile
and so called EE phenotype. The other pates
are just shit. And that,s why all three reviewers including us rejected them
directly. However,they made a deal with
editor.
【在 n********k 的大作中提到】
: but to me, a bit too good/dramatic to be true...I have no doubt the
: hypothesis/conclusion likely will stand but
: I would think that the dramatic effects resulted from ER in these cancer
: models is by far too good from what
: many would expect...
: Anyway, here is one of most interesting/amazing papers lately
: Environmental and Genetic Activation of a Brain-Adipocyte BDNF/Leptin Axis
: Causes Cancer Remission and
: Inhibition
: http://www.cell.com/issue?pii=S0092-8674(10)X0014-9
|
n********k
发帖数: 2818 | 14 thanks and I c...this would make a lot more sense...
them
【在 a******g 的大作中提到】
: You are coaxed by the sexy title.
: Our lab reviewed this paper for Cell. Actually, the only sexy part is tile
: and so called EE phenotype. The other pates
: are just shit. And that,s why all three reviewers including us rejected them
: directly. However,they made a deal with
: editor.
|
b****u
发帖数: 903 | 15 shafa,
how did they make a deal with editor to publish a paper in Cell under the
three rejected reviews? If that happen why we need the reviews system?
them
【在 a******g 的大作中提到】
: You are coaxed by the sexy title.
: Our lab reviewed this paper for Cell. Actually, the only sexy part is tile
: and so called EE phenotype. The other pates
: are just shit. And that,s why all three reviewers including us rejected them
: directly. However,they made a deal with
: editor.
|
s******y
发帖数: 28562 | 16 这篇文章的分子生物的部分的确有点奇怪，希望能有人出来证实或者推翻它
them
【在 a******g 的大作中提到】
: You are coaxed by the sexy title.
: Our lab reviewed this paper for Cell. Actually, the only sexy part is tile
: and so called EE phenotype. The other pates
: are just shit. And that,s why all three reviewers including us rejected them
: directly. However,they made a deal with
: editor.
|
s******y
发帖数: 28562 | 17 如果是大牛实验室，的确是有可能的。
【在 b****u 的大作中提到】
: shafa,
: how did they make a deal with editor to publish a paper in Cell under the
: three rejected reviews? If that happen why we need the reviews system?
:
: them
|
a****d
发帖数: 1919 | 18 Interesting to learn about some inside info
How did they still publish this paper then? That's scaring...
them
【在 a******g 的大作中提到】
: You are coaxed by the sexy title.
: Our lab reviewed this paper for Cell. Actually, the only sexy part is tile
: and so called EE phenotype. The other pates
: are just shit. And that,s why all three reviewers including us rejected them
: directly. However,they made a deal with
: editor.
|
j*****d
发帖数: 787 | 19
Is this what you mean "the dirty part" of working mechanisms of funding in
US?
【在 s******y 的大作中提到】
: 如果是大牛实验室，的确是有可能的。
|
s******y
发帖数: 28562 | 20 这个顶多算冰山一角而已
【在 j*****d 的大作中提到】
:
: Is this what you mean "the dirty part" of working mechanisms of funding in
: US?
|
|
|
s******y
发帖数: 28562 | 21 有些报复心强的大牛，甚至会向主编要来你的名字，然后以后慢慢修理你。
我老板现在是一旦看到某些大牛的文章被主编投过来审阅的话就装病或者说
没有时间。
【在 s******y 的大作中提到】
: 这个顶多算冰山一角而已
|
j*****d
发帖数: 787 | 22
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
that's good. haha. I am a little bit positive to this paper and her new
career. My extra point is that it may be dependent on the type of cancer.
【在 H*********1 的大作中提到】
: I have the same feeling: too good to be true.
: i do not know other labs can repeat it or not.
: BTW, the first author already got a PI position in NY.
|
O******e
发帖数: 4845 | 23 这么恐怖？？
【在 s******y 的大作中提到】
: 有些报复心强的大牛，甚至会向主编要来你的名字，然后以后慢慢修理你。
: 我老板现在是一旦看到某些大牛的文章被主编投过来审阅的话就装病或者说
: 没有时间。
|
b****n
发帖数: 311 | 24 Cell press is a company right? Editors, especially editor in chief have
the right to publish a paper regardless of the 3 negative reviewers. This
paper is not the first one, and will not be the last one.
the
【在 b****u 的大作中提到】
: shafa,
: how did they make a deal with editor to publish a paper in Cell under the
: three rejected reviews? If that happen why we need the reviews system?
:
: them
|
b****n
发帖数: 311 | 25 I never know this. seems impossible, it crosses the bottom line.
【在 s******y 的大作中提到】
: 有些报复心强的大牛，甚至会向主编要来你的名字，然后以后慢慢修理你。
: 我老板现在是一旦看到某些大牛的文章被主编投过来审阅的话就装病或者说
: 没有时间。
|
h********n
发帖数: 4079 | 26 there is a new paper in the latest Nature Protocol describing this EE cage.
当年我们投稿也被人报复了,不过倒没有浪费很多时间, 因为editor直接退稿. 郁闷的
是, 我老板也是editor. 所以明确知道是谁因为什么事情报复. |
