n********k
发帖数: 2818 | 1 Altered histone acetylation is associated with age-dependent memory
impairment in mice.
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa
RC, Cota P, Wittnam JL, Gogol-
Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L,
Chen W, Fischer A.
Science. 2010 May 7;328(5979):753-6. Erratum in: Science. 2010 Jun 25;328(
5986):1634.
Recovery of learning and memory is associated with chromatin remodelling.
Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai | k*****o
发帖数: 1486 | 2 Epigenetics is a hot field now. It has just been realized that the
traditional genome sequence is far from enough for eukaryotes. | n********k
发帖数: 2818 | 3 U have not got it , buddy, think it a bit harder:))))
【在 k*****o 的大作中提到】
: Epigenetics is a hot field now. It has just been realized that the
: traditional genome sequence is far from enough for eukaryotes.
| a****d
发帖数: 1919 | 4 Are u suggesting that, whatever regulating neurogenesis during early brain
development also contribute to later synapse formation/modification; in
another word, the similar complexes involved in neural diversity also direct
neural circuit formation and have an impact on learning and memory?
I always have trouble on papers from Tsai's lab though...Seems sometimes
they pushed too much | A******y
发帖数: 2041 | 5 Hey HDAC2 doesn't work, let's do SIRT1. The funny thing is that SIRT1 might
not even be a deacetylase in-vivo. | b****n
发帖数: 311 | 6 can you elaborate a little bit? I heard some not so good words on HDAC2,
but haven't got it clearly.
might
【在 A******y 的大作中提到】
: Hey HDAC2 doesn't work, let's do SIRT1. The funny thing is that SIRT1 might
: not even be a deacetylase in-vivo.
| n********k
发帖数: 2818 | 7 for a serious scientist, one would always read and read critically, and
forget about what the authors'
interpretation, logy or whatever...at certain level and to discern the truth
from the mist, one would have to
read beyond a paper...
【在 b****n 的大作中提到】
: can you elaborate a little bit? I heard some not so good words on HDAC2,
: but haven't got it clearly.
:
: might
| l******e
发帖数: 427 | 8 agree with your last sentence...
direct
【在 a****d 的大作中提到】
: Are u suggesting that, whatever regulating neurogenesis during early brain
: development also contribute to later synapse formation/modification; in
: another word, the similar complexes involved in neural diversity also direct
: neural circuit formation and have an impact on learning and memory?
: I always have trouble on papers from Tsai's lab though...Seems sometimes
: they pushed too much
|
|
