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发帖数: 11983 | 1 http://asheducationbook.hematologylibrary.org/cgi/content/full/
Ham-Wasserman Lecture
Treatment of Acute Leukemia by Inducing Differentiation and Apoptosis
Zhen-yi Wang, MD*
Abstract
Conventional treatment of acute leukemia involves the use of cytotoxic
agents (chemotherapy), but other strategies have been explored. All-trans
retinoic acid (ATRA) and arsenic have clearly been effective in the
treatment of acute promyelocytic leukemia (APL), which creates the
possibility that other types of acute leukemia can be conquered by
selectively inducing differentiation and/or apoptosis. A great number of
investigations have been performed to elucidate the mechanisms and search
for effective agents in the treatment of other types of acute leukemia by
these new strategies. Progress at the molecular level has been achieved in
explaining the mechanisms of action of ATRA and arsenic compounds, and
several new agents have emerged, although their clinical effectiveness
remains to be confirmed. Mechanism-/gene-based targeted therapy and a
combination of different strategies will improve the treatment of acute
leukemia. |
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