m******5
发帖数: 1383 | 1 最近作microarray数据（in the context of development ）
遇到几个比较有意思的CXCL family ，包括cxcl1, cxcl5等上调，下调
在网上查了查文章，似乎cxcl family ligand很多人都是在免疫学的context下研究的
，比较少看见在development biology的context下做的
所以想问问cxcl family在development里有什么研究成果？最好推荐一些好的综述，非
常感谢！！！ | m******5
发帖数: 1383 | | m******5
发帖数: 1383 | | n***w
发帖数: 2405 | 4 is that immune system plays a role in development which may explain why you
observe those cytokine changes? | m******5
发帖数: 1383 | 5 I don't think it is necessary a role related to immune system: for example,
cxcl-cxcr are important for germ cell migration during development, and
sometimes cxcls are directly related to migration of progenitor cell such us
osteoblast .
But I am still feeling that I am missing a big picture…… which makes me
very uncomfortable
you
【在 n***w 的大作中提到】
: is that immune system plays a role in development which may explain why you
: observe those cytokine changes?
| c********r
发帖数: 1125 | 6 这个chemokine CXCL family factors在发育里面的作用不是什么很新的东西了，在PGC
迁移，肌肉前体细胞迁移，血管发生上面都有报道了。
我记得比较清楚的是在斑马鱼里面的工作，你可以参考:
Siekmann, A.F., Standley, C., Fogarty, K.E., Wolfe, S.A., Lawson, N.D. (2009
): Chemokine signaling guides regional patterning of the first embryonic
artery. Genes & Development, 1;23(19): 2272-7.
Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E. and
Birchmeier, C. (2005)
CXCR4 and Gab1 cooperate to control the development of migrating muscle
progenitor cells.
Genes and Development 19: 2187-2198.(Abstract - Pub Med)
Boldajipour, B.*, Mahabaleshwar, H.*, Kardash, E., Reichman-Fried, M.,
Blaser, H., Minina, S., Wilson, D., Xu, Q. and Raz, E. (2008)
Control of Chemokine-Guided Cell Migration by Ligand Sequestration
Cell 132: 463-473. *Equal contribution (Abstract - Pub Med) | b*******n
发帖数: 8420 | 7 LS说得没错，chemokine可以引导细胞迁移。
当然如果你非要联系到免疫方面的话（如果那几个发生变化的chemokine ligand/
receptor的主要作用是招募免疫细胞），那么一种可能的解释就是有些免疫细胞被招募
到某些site，消灭掉一些组织细胞，从而实现remodelling. | m******5
发帖数: 1383 | 8 THank you!
PGC
2009
【在 c********r 的大作中提到】
: 这个chemokine CXCL family factors在发育里面的作用不是什么很新的东西了，在PGC
: 迁移，肌肉前体细胞迁移，血管发生上面都有报道了。
: 我记得比较清楚的是在斑马鱼里面的工作，你可以参考:
: Siekmann, A.F., Standley, C., Fogarty, K.E., Wolfe, S.A., Lawson, N.D. (2009
: ): Chemokine signaling guides regional patterning of the first embryonic
: artery. Genes & Development, 1;23(19): 2272-7.
: Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E. and
: Birchmeier, C. (2005)
: CXCR4 and Gab1 cooperate to control the development of migrating muscle
: progenitor cells.
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