v****e
发帖数: 131 | 1 I am an Assistant Professor in the Dept. of Molecular and Cellular Biology
at Baylor College of Medicine, Houston, Texas. A postdoctoral fellow
position is currently available in my lab. My research interests/projects
include:
1. ERK3 signaling in cancer progression and metastasis, with a particular
interest in inflammation-associated cancer progression and metastasis.
Extracellular signal-regulated kinase 3 (ERK3) is a member of the atypical
MAP kinase subfamily. Unlike ERK1 and ERK2 that have been studied
extensively, little is known about the upstream stimuli and activators of
ERK3 or its downstream targets. The function of ERK3 in cancer development
and progression is virtually unknown. We recently revealed a novel function
of ERK3 in regulating cancer cell invasiveness. A manuscript from the early
-phase study of this project is under review in Molecular Cell.
2. Role of SRC-3Δ4, a splice isoform of steroid receptor coactivator 3 (SRC
-3), in the progression and metastasis of castration-resistant prostate
cancer. The objective of this project is to define the role of SRC-3Δ4 in
castration-resistant prostate cancer progression and to identify the
underlying mechanisms of how SRC-3Δ4 coordinates EGF signaling to activate
AR and promote androgen-independent tumor progression.
3. Role of SRC-3Δ4 in anti-hormone resistant breast cancer progression and
metastasis. The essential objective of this project is to test whether SRC-3
∆4 integrates E2 non-genomic and genomic actions to promote breast
cancer progression and elicit anti-estrogen resistance.
A relevant reference for SRC-3Δ4 projects:
Long W, Yi P, Amazit L, LaMarca HL, Ashcroft F, Kumar R, Mancini MA, Tsai SY
, Tsai MJ, O'Malley BW. 2010. SRC-3Delta4 mediates the interaction of EGFR
with FAK to promote cell migration. Molecular Cell, 37(3):321-32
Contact information:
Weiwen Long, Ph.D.
Assistant Professor
Department of Molecular and Cellular Biology
Baylor College of Medicine
One Baylor Plaza
Houston, Texas 77030
E-mail: w***[email protected]
Phone: 832-866-4881 | h*****t
发帖数: 103 | | G**d
发帖数: 733 | 3 ding
【在 v****e 的大作中提到】
: I am an Assistant Professor in the Dept. of Molecular and Cellular Biology
: at Baylor College of Medicine, Houston, Texas. A postdoctoral fellow
: position is currently available in my lab. My research interests/projects
: include:
: 1. ERK3 signaling in cancer progression and metastasis, with a particular
: interest in inflammation-associated cancer progression and metastasis.
: Extracellular signal-regulated kinase 3 (ERK3) is a member of the atypical
: MAP kinase subfamily. Unlike ERK1 and ERK2 that have been studied
: extensively, little is known about the upstream stimuli and activators of
: ERK3 or its downstream targets. The function of ERK3 in cancer development
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