F*Q
发帖数: 3259 | 1 马上要扔炸弹了，有点 anxious，有点excited ...
大家来bless 吧， 炸响后发包子！ |
b******y
发帖数: 627 | |
D*a
发帖数: 6830 | |
F*Q
发帖数: 3259 | 4 马上就要投了 。 炸响后，给你发双簧包子 :)
【在 D*a 的大作中提到】
: 投了？
: bless～
|
D*a
发帖数: 6830 | 5 那我再bless一下吧，双黄bless～
【在 F*Q 的大作中提到】
: 马上就要投了 。 炸响后，给你发双簧包子 :)
|
r***e
发帖数: 2539 | 6 bless!
核弹级别的？
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
m******r
发帖数: 854 | |
S**8
发帖数: 10010 | 8 Bless~
核弹成功爆炸。。。惊天动地~~
排包子。。。 |
|
B****w
发帖数: 48 | |
y**********n
发帖数: 478 | |
|
|
F*Q
发帖数: 3259 | 11 似乎是的，大规模杀伤性武器。
有人说，我以前做东西总是不经意间把老板给杀伤了，那还只是个别杀伤。这次，老板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
【在 r***e 的大作中提到】
: bless!
: 核弹级别的？
|
B****a
发帖数: 1526 | 12 bless...
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
o**d
发帖数: 3080 | |
c****b
发帖数: 1230 | |
p***a
发帖数: 6202 | |
g*********5
发帖数: 2533 | |
m***i
发帖数: 2013 | |
s******y
发帖数: 28562 | 18 祝福投弹成功
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
I***a
发帖数: 13467 | |
c********r
发帖数: 189 | |
|
|
c*********7
发帖数: 148 | |
F*Q
发帖数: 3259 | 22 要的不仅是投弹成功，而且要炸出蘑菇云。一旦出现蘑菇云，你会看到的。我现在需要
的是bless 炸出蘑菇云来
【在 c*********7 的大作中提到】
: 投弹成功后别忘给链接，谢谢！！
|
F*Q
发帖数: 3259 | 23 多谢!毛主席保佑你.
【在 c********r 的大作中提到】
: bless!
: 别炸到我哦~
|
l*****a
发帖数: 1431 | |
i*e
发帖数: 352 | 25 向我开炮！以包子做炮弹。
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
T******e
发帖数: 4863 | |
b*******n
发帖数: 8420 | |
j*****9
发帖数: 716 | 28 尽快 Epub ahead of print!!!哈哈哈，等包子 |
l**********1
发帖数: 5204 | 29 LZ were late from Cell already published:
please go to
//www.ncbi.nlm.nih.gov/pubmed/21414480
Cell. 2011 Mar 18;144(6):874-
It is clear that the Xenopus embryonic cell cycle can operate in
the absence of transcription. Therefore, we have regarded the
cell-cycle oscillator as only a protein circuit—proteins regulate
other proteins, but not gene expression. Nonetheless, many cellcycle
regulators in many cell types undergo periodic transcription
(Spellman et al., 1998). Indeed, in budding yeast, transcriptional
oscillations persist in the absence of CDK1 oscillations (Haase
and Reed, 1999; Orlando et al., 2008). Transcriptional regulation
undoubtedly contributes to the overall functioning of the cell-cycle
oscillator, with the protein oscillator acting as a basic core circuit
upon which additional controls have been layered.
【在 F*Q 的大作中提到】
: 要的不仅是投弹成功，而且要炸出蘑菇云。一旦出现蘑菇云，你会看到的。我现在需要
: 的是bless 炸出蘑菇云来
|
l**********1
发帖数: 5204 | 30 Continue:
Cell cycle/Budding new mechanisms cutting edge approaching:
//adsabs.harvard.edu/abs/2010arXiv1011.2435B
Beersma, D. G. M.; Broer, H. W.; Efstathiou, K.; Gargar, K. A.; Hoveijn, I.
Pacer cell response to periodic Zeitgebers (2011)
Physica D: Nonlinear Phenomena, Volume 240, Issue 19, p. 1516-
cited:
>(5) asymmetry in the observed period
and the phase delay and phase advance components of phase
response curves. Aside from these, we also now have a set
of four directly observable parameters to look at more closely
in biological systems.
Most experiments in the past have only searched for genes and proteins
responsible for the
intrinsic period τ . However, circadian clocks are also characterized by
their phase
response curves which in the simple pacer model are defined
with only three more basic parameters α, ε, η. We think that an
important predictive value of the current work is our discovery
of the mathematical relationships between these four parameters
and their contribution to various aspects of entrainment. Now,
one direction that biologists should pursue is to do extensive
experimentation to search in the complex biochemical system for
molecular components which could be responsible for the phase
delay and phase advance parameters ε and η, respectively, as
well as the intrinsic activity length α. Finally, one may say that
the model is too simple to capture the entire phase response
characteristics of whole organisms, or even of a single pacer
cell. The PRC used must be rather realistic for an individual
pacemaker cell, at least if our assumption that the behavior can
be characterized by two states (electrical activity versus rest)
is correct. The result of the interactions between the various
pacemaker cells and their response to light will eventually lead
to the known PRCs of the ensemble, in which phase delays occur
at the end of the photoperiod and advances at the beginning.
However, we must emphasize that even this very simple model
with only four parameters already captures those characteristics
mentioned above, that is, we did not use a more realistic phase
response curve [23] to simulate those characteristics. Properties
that we can see in the model such as hysteresis (see Fig. 5) and
period-halving and period-doubling cascades (see Fig. 11) remain
to be seen in experiments at the behavioral and lower levels.
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
|
|
F*Q
发帖数: 3259 | 31 You might have been misled. Sorry.
But I do appreciate your great efforts to help. You are going to receive
another Baozi too if my NUKE explodes successfully.
【在 l**********1 的大作中提到】
: LZ were late from Cell already published:
: please go to
: //www.ncbi.nlm.nih.gov/pubmed/21414480
: Cell. 2011 Mar 18;144(6):874-
: It is clear that the Xenopus embryonic cell cycle can operate in
: the absence of transcription. Therefore, we have regarded the
: cell-cycle oscillator as only a protein circuit—proteins regulate
: other proteins, but not gene expression. Nonetheless, many cellcycle
: regulators in many cell types undergo periodic transcription
: (Spellman et al., 1998). Indeed, in budding yeast, transcriptional
|
n********t
发帖数: 1079 | |
F*Q
发帖数: 3259 | 33 还没投，投之前先求求神灵保佑 :)
【在 n********t 的大作中提到】
: 核弹炸响没？Good luck!
|
c*********7
发帖数: 148 | 34 这你起码说说你的领域吧。。。否则不好follow啊。。。估计你这文章肯定是投CNS了
吧。。。
【在 F*Q 的大作中提到】
: 要的不仅是投弹成功，而且要炸出蘑菇云。一旦出现蘑菇云，你会看到的。我现在需要
: 的是bless 炸出蘑菇云来
|
F*Q
发帖数: 3259 | 35 你的好奇心好强啊。不过我会在这里随时更新的。
好好bless吧，bless越多，爆炸的威力越大，包子也越多
【在 c*********7 的大作中提到】
: 这你起码说说你的领域吧。。。否则不好follow啊。。。估计你这文章肯定是投CNS了
: 吧。。。
|
r****t
发帖数: 10904 | 36 只有大牛实验室才能重复你的实验的，想来也不是啥核弹，如果全世界有上千个实验室
能重复你的实验，而没有人想过去做，或者没有人想到你结论可能是对的，那样的算核
弹。
板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
【在 F*Q 的大作中提到】
: 似乎是的，大规模杀伤性武器。
: 有人说，我以前做东西总是不经意间把老板给杀伤了，那还只是个别杀伤。这次，老板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
|
F*Q
发帖数: 3259 | 37 管它黑蛋白蛋，只要能炸出来蘑菇云来就是好蛋！毛主席万岁！阿弥陀佛
【在 r****t 的大作中提到】
: 只有大牛实验室才能重复你的实验的，想来也不是啥核弹，如果全世界有上千个实验室
: 能重复你的实验，而没有人想过去做，或者没有人想到你结论可能是对的，那样的算核
: 弹。
:
: 板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
|
c*********7
发帖数: 148 | 38 对我来说，能有CNS就万岁了，炸谁都无所谓。Anyway，随时follow你的更新，别忘了
给包子！
Bless。。。
但愿别到4月1号的时候，你告诉我们你在开玩笑。。。
【在 F*Q 的大作中提到】
: 你的好奇心好强啊。不过我会在这里随时更新的。
: 好好bless吧，bless越多，爆炸的威力越大，包子也越多
|
s****l
发帖数: 10462 | |
F*Q
发帖数: 3259 | 40 马上要扔炸弹了，有点 anxious，有点excited ...
大家来bless 吧， 炸响后发包子！ |
|
|
b******y
发帖数: 627 | |
D*a
发帖数: 6830 | |
F*Q
发帖数: 3259 | 43 马上就要投了 。 炸响后，给你发双簧包子 :)
【在 D*a 的大作中提到】
: 投了？
: bless～
|
D*a
发帖数: 6830 | 44 那我再bless一下吧，双黄bless～
【在 F*Q 的大作中提到】
: 马上就要投了 。 炸响后，给你发双簧包子 :)
|
r***e
发帖数: 2539 | 45 bless!
核弹级别的？
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
m******r
发帖数: 854 | |
S**8
发帖数: 10010 | 47 Bless~
核弹成功爆炸。。。惊天动地~~
排包子。。。 |
B****w
发帖数: 48 | |
y**********n
发帖数: 478 | |
F*Q
发帖数: 3259 | 50 似乎是的，大规模杀伤性武器。
有人说，我以前做东西总是不经意间把老板给杀伤了，那还只是个别杀伤。这次，老板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
【在 r***e 的大作中提到】
: bless!
: 核弹级别的？
|
|
|
B****a
发帖数: 1526 | 51 bless...
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
o**d
发帖数: 3080 | |
c****b
发帖数: 1230 | |
p***a
发帖数: 6202 | |
g*********5
发帖数: 2533 | |
m***i
发帖数: 2013 | |
s******y
发帖数: 28562 | 57 祝福投弹成功
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
I***a
发帖数: 13467 | |
c********r
发帖数: 189 | |
c*********7
发帖数: 148 | |
|
|
F*Q
发帖数: 3259 | 61 要的不仅是投弹成功，而且要炸出蘑菇云。一旦出现蘑菇云，你会看到的。我现在需要
的是bless 炸出蘑菇云来
【在 c*********7 的大作中提到】
: 投弹成功后别忘给链接，谢谢！！
|
F*Q
发帖数: 3259 | 62 多谢!毛主席保佑你.
【在 c********r 的大作中提到】
: bless!
: 别炸到我哦~
|
l*****a
发帖数: 1431 | |
i*e
发帖数: 352 | 64 向我开炮！以包子做炮弹。
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
T******e
发帖数: 4863 | |
b*******n
发帖数: 8420 | |
j*****9
发帖数: 716 | 67 尽快 Epub ahead of print!!!哈哈哈，等包子 |
l**********1
发帖数: 5204 | 68 LZ were late from Cell already published:
please go to
//www.ncbi.nlm.nih.gov/pubmed/21414480
Cell. 2011 Mar 18;144(6):874-
It is clear that the Xenopus embryonic cell cycle can operate in
the absence of transcription. Therefore, we have regarded the
cell-cycle oscillator as only a protein circuit—proteins regulate
other proteins, but not gene expression. Nonetheless, many cellcycle
regulators in many cell types undergo periodic transcription
(Spellman et al., 1998). Indeed, in budding yeast, transcriptional
oscillations persist in the absence of CDK1 oscillations (Haase
and Reed, 1999; Orlando et al., 2008). Transcriptional regulation
undoubtedly contributes to the overall functioning of the cell-cycle
oscillator, with the protein oscillator acting as a basic core circuit
upon which additional controls have been layered.
【在 F*Q 的大作中提到】
: 要的不仅是投弹成功，而且要炸出蘑菇云。一旦出现蘑菇云，你会看到的。我现在需要
: 的是bless 炸出蘑菇云来
|
l**********1
发帖数: 5204 | 69 Continue:
Cell cycle/Budding new mechanisms cutting edge approaching:
//adsabs.harvard.edu/abs/2010arXiv1011.2435B
Beersma, D. G. M.; Broer, H. W.; Efstathiou, K.; Gargar, K. A.; Hoveijn, I.
Pacer cell response to periodic Zeitgebers (2011)
Physica D: Nonlinear Phenomena, Volume 240, Issue 19, p. 1516-
cited:
>(5) asymmetry in the observed period
and the phase delay and phase advance components of phase
response curves. Aside from these, we also now have a set
of four directly observable parameters to look at more closely
in biological systems.
Most experiments in the past have only searched for genes and proteins
responsible for the
intrinsic period τ . However, circadian clocks are also characterized by
their phase
response curves which in the simple pacer model are defined
with only three more basic parameters α, ε, η. We think that an
important predictive value of the current work is our discovery
of the mathematical relationships between these four parameters
and their contribution to various aspects of entrainment. Now,
one direction that biologists should pursue is to do extensive
experimentation to search in the complex biochemical system for
molecular components which could be responsible for the phase
delay and phase advance parameters ε and η, respectively, as
well as the intrinsic activity length α. Finally, one may say that
the model is too simple to capture the entire phase response
characteristics of whole organisms, or even of a single pacer
cell. The PRC used must be rather realistic for an individual
pacemaker cell, at least if our assumption that the behavior can
be characterized by two states (electrical activity versus rest)
is correct. The result of the interactions between the various
pacemaker cells and their response to light will eventually lead
to the known PRCs of the ensemble, in which phase delays occur
at the end of the photoperiod and advances at the beginning.
However, we must emphasize that even this very simple model
with only four parameters already captures those characteristics
mentioned above, that is, we did not use a more realistic phase
response curve [23] to simulate those characteristics. Properties
that we can see in the model such as hysteresis (see Fig. 5) and
period-halving and period-doubling cascades (see Fig. 11) remain
to be seen in experiments at the behavioral and lower levels.
【在 F*Q 的大作中提到】
: 马上要扔炸弹了，有点 anxious，有点excited ...
: 大家来bless 吧， 炸响后发包子！
|
F*Q
发帖数: 3259 | 70 You might have been misled. Sorry.
But I do appreciate your great efforts to help. You are going to receive
another Baozi too if my NUKE explodes successfully.
【在 l**********1 的大作中提到】
: LZ were late from Cell already published:
: please go to
: //www.ncbi.nlm.nih.gov/pubmed/21414480
: Cell. 2011 Mar 18;144(6):874-
: It is clear that the Xenopus embryonic cell cycle can operate in
: the absence of transcription. Therefore, we have regarded the
: cell-cycle oscillator as only a protein circuit—proteins regulate
: other proteins, but not gene expression. Nonetheless, many cellcycle
: regulators in many cell types undergo periodic transcription
: (Spellman et al., 1998). Indeed, in budding yeast, transcriptional
|
|
|
n********t
发帖数: 1079 | |
F*Q
发帖数: 3259 | 72 还没投，投之前先求求神灵保佑 :)
【在 n********t 的大作中提到】
: 核弹炸响没？Good luck!
|
c*********7
发帖数: 148 | 73 这你起码说说你的领域吧。。。否则不好follow啊。。。估计你这文章肯定是投CNS了
吧。。。
【在 F*Q 的大作中提到】
: 要的不仅是投弹成功，而且要炸出蘑菇云。一旦出现蘑菇云，你会看到的。我现在需要
: 的是bless 炸出蘑菇云来
|
F*Q
发帖数: 3259 | 74 你的好奇心好强啊。不过我会在这里随时更新的。
好好bless吧，bless越多，爆炸的威力越大，包子也越多
【在 c*********7 的大作中提到】
: 这你起码说说你的领域吧。。。否则不好follow啊。。。估计你这文章肯定是投CNS了
: 吧。。。
|
r****t
发帖数: 10904 | 75 只有大牛实验室才能重复你的实验的，想来也不是啥核弹，如果全世界有上千个实验室
能重复你的实验，而没有人想过去做，或者没有人想到你结论可能是对的，那样的算核
弹。
板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
【在 F*Q 的大作中提到】
: 似乎是的，大规模杀伤性武器。
: 有人说，我以前做东西总是不经意间把老板给杀伤了，那还只是个别杀伤。这次，老板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
|
F*Q
发帖数: 3259 | 76 管它黑蛋白蛋，只要能炸出来蘑菇云来就是好蛋！毛主席万岁！阿弥陀佛
【在 r****t 的大作中提到】
: 只有大牛实验室才能重复你的实验的，想来也不是啥核弹，如果全世界有上千个实验室
: 能重复你的实验，而没有人想过去做，或者没有人想到你结论可能是对的，那样的算核
: 弹。
:
: 板总算躲过了，但可能杀伤一片，一大片啊，血流成河！阿弥陀佛...
|
c*********7
发帖数: 148 | 77 对我来说，能有CNS就万岁了，炸谁都无所谓。Anyway，随时follow你的更新，别忘了
给包子！
Bless。。。
但愿别到4月1号的时候，你告诉我们你在开玩笑。。。
【在 F*Q 的大作中提到】
: 你的好奇心好强啊。不过我会在这里随时更新的。
: 好好bless吧，bless越多，爆炸的威力越大，包子也越多
|
s****l
发帖数: 10462 | |
h********0
发帖数: 12056 | |
F*Q
发帖数: 3259 | 80 想要的话，每天都可以是四月一号
【在 h********0 的大作中提到】
: 今年四月一日提前了？
|
