p***g
发帖数: 66 | 1 我从文献中得到了一些疾病相关的SNP(single point mutations, for example,
rs85462)和对应Gene. 我想看看这些SNP都是什么类型: frameshift, missense,
nonsense etc. 该查什么database, db.snp?
然后我想作图看看mutations 分布在哪些protein domain (象附件图). 需要用什么
databases (protein domain mapping) 和什么软件. 请各位多多指点, 万分感激!
A little more information: I need to check several hundreds of SNPs for tens
of genes. Just visualize their distribution and effect on protein function/
structure. That’s why I need some software/web applications to do it. |
l*****a
发帖数: 1431 | |
K********A
发帖数: 917 | 3 这个问题问出来凸显楼主和阿三的差距，高中生都知道这个图怎么弄。。粗糙点
powerpoint都可以画 |
p***g
发帖数: 66 | 4 Thank you guys. I remember I’ve read some programs can do this, but couldn
’t find the article now. Yes, this one does look like being manually drawn.
But are there any software/websites generating such diagram automatically?
Meanwhile, the protein domain data and SNP type (frameshift, missense) must
come from some databases. What are they? Thanks a lot! |
i*******n
发帖数: 48 | 5 1)SNP database
http://www.ncbi.nlm.nih.gov/snp
domain database
http://www.ncbi.nlm.nih.gov/cdd
2)cancer mutation database
http://www.sanger.ac.uk/genetics/CGP/cosmic/
3)Map SNP to domain
http://polydoms.cchmc.org/polydoms/
4)Map SNP to structure
http://www.bioinf.org.uk/saap/
couldn
drawn.
?
must
【在 p***g 的大作中提到】
: Thank you guys. I remember I’ve read some programs can do this, but couldn
: ’t find the article now. Yes, this one does look like being manually drawn.
: But are there any software/websites generating such diagram automatically?
: Meanwhile, the protein domain data and SNP type (frameshift, missense) must
: come from some databases. What are they? Thanks a lot!
|
p***g
发帖数: 66 | 6 Thanks a lot for the detailed list. |
u**********d
发帖数: 573 | |
