x********e
发帖数: 2275 | 1 请发到：h******[email protected]
先谢过了！
Adrenomedullins: Therapeutic Potential in Cardiovascular Disease
Author: J. Charles, Christopher
Source: Current Hypertension Reviews, Volume 7, Number 4, December 2011 , pp
. 284-291(8)
Abstract:
Cardiovascular disease is a leading cause of death and disability and
despite advances in treatment there remains an ongoing need to develop new
therapeutic interventions. Accumulating evidence points towards an important
role for the adrenomedullin (AM) family of peptides in pressure/volume
homeostasis and indicate potential as therapeutic agents in a variety of
clinical settings including cardiovascular disease. Plasma levels of AM are
raised in cardiovascular disease in proportion to severity of cardiac
dysfunction and are useful prognostic indicators of outcome. AM
administration in both experimental and human heart failure induces a
beneficial spectrum of biological action including reduced arterial and
atrial pressures, improved cardiac output, inhibition of plasma aldosterone
and preservation or augmentation of urinary sodium excretion. Experimental
data also supports a role for AM in cardioprotection in cardiac ischemia/
reperfusion injury and in the progression of heart failure following
myocardial infarction. Thus, strategies to manipulate the AM system may
prove beneficial as adjunctive therapy in cardiovascular disease. | x********e
发帖数: 2275 | 2 Got it from the author.
pp
important
【在 x********e 的大作中提到】
: 请发到：h******[email protected]
: 先谢过了！
: Adrenomedullins: Therapeutic Potential in Cardiovascular Disease
: Author: J. Charles, Christopher
: Source: Current Hypertension Reviews, Volume 7, Number 4, December 2011 , pp
: . 284-291(8)
: Abstract:
: Cardiovascular disease is a leading cause of death and disability and
: despite advances in treatment there remains an ongoing need to develop new
: therapeutic interventions. Accumulating evidence points towards an important
|
|
