x**********o 发帖数: 142 | 1 Cell Physiol Biochem. 2013;31(1):113-22. doi: 10.1159/000343354. Epub 2013
Jan 25.
External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF-
312;B and induces cell cycle arrest and apoptosis in colorectal cancer cells.
Yan X, Shen H, Jiang H, Hu D, Wang J, Wu X.
Background/Aims: Colorectal cancer (CRC) is the second leading cause of
cancer death in the Western countries. Novel approaches of treatment are
needed for CRC. The purpose of the present study was to investigate
cytotoxic effect of external Qi of Yan Xin Qigong (YXQ-EQ) on human
colorectal cancer cells. Methods: The effect of YXQ-EQ on viability, cell
cycle progression and apoptosis in colorectal cancer HT-29 cells was
investigated. Phosphorylation of Akt and Erk1/2, activation of NF-ĸB
and the expression of proteins involved in regulation of cell cycle and
apoptosis were examined by Western blot analysis. Results: YXQ-EQ markedly
decreased viability and blocked colony formation of HT-29 cells. YXQ-EQ
downregulated cyclin D1 expression and increased accumulation of cyclin-
dependent kinase inhibitors p21(Cip1) and p27(Kip1), resulting in G1 cell
cycle arrest. YXQ-EQ induced apoptosis in HT-29 cells in association with
decreased expression of antiapoptotic proteins Bcl-xL, XIAP, survivin and
Mcl-1 and elevated expression of proapoptotic protein Bax. YXQ-EQ
significantly repressed phosphorylation of Akt and Erk1/2 and NF-ĸB
activation in HT-29 cells, suggesting that YXQ-EQ may exert cytotoxic effect
through regulating signaling pathways critical for cell proliferation and
survival. Furthermore, YXQ-EQ treated PBS and an YXQ-EQ treated plant
extract induced apoptosis in HT-29 cells. Conclusion: These findings show
that YXQ-EQ has potent cytotoxic effect on HT-29 cells and suggest that YXQ-
EQ could be potentially used for colorectal cancer treatment either directly
or indirectly via carriers. |
c**********r 发帖数: 891 | 2 IF 3,还不低呢。
通讯作者是哈佛医学院的。
还专门给“external Qi of Yanxin Qigong”弄了个缩写代号YXQ-EQ,这是为了显得更
高科技?
cells.
【在 x**********o 的大作中提到】![](/moin_static193/solenoid/img/up.png) : Cell Physiol Biochem. 2013;31(1):113-22. doi: 10.1159/000343354. Epub 2013 : Jan 25. : External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF- : 312;B and induces cell cycle arrest and apoptosis in colorectal cancer cells. : Yan X, Shen H, Jiang H, Hu D, Wang J, Wu X. : Background/Aims: Colorectal cancer (CRC) is the second leading cause of : cancer death in the Western countries. Novel approaches of treatment are : needed for CRC. The purpose of the present study was to investigate : cytotoxic effect of external Qi of Yan Xin Qigong (YXQ-EQ) on human : colorectal cancer cells. Methods: The effect of YXQ-EQ on viability, cell
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S*********s 发帖数: 304 | 3 骗international reviewer
读paper,会以为是个drug
【在 c**********r 的大作中提到】![](/moin_static193/solenoid/img/up.png) : IF 3,还不低呢。 : 通讯作者是哈佛医学院的。 : 还专门给“external Qi of Yanxin Qigong”弄了个缩写代号YXQ-EQ,这是为了显得更 : 高科技? : : cells.
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m*******n 发帖数: 387 | |
q******g 发帖数: 3858 | 5 不止一篇呢,我看到他们发了好几篇。这个实验别人根本没法重复阿。 |
q******g 发帖数: 3858 | 6 他们可以给白血病病人发功,抽出血样,看看细胞的变化,看看基因表达的变化,蛋白
的变化,如果有足够多的病人有好转,说不定能发NEJM. |
a*********n 发帖数: 2526 | 7 这怎么作control啊,如何消除placebo effect?
【在 q******g 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 他们可以给白血病病人发功,抽出血样,看看细胞的变化,看看基因表达的变化,蛋白 : 的变化,如果有足够多的病人有好转,说不定能发NEJM.
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A******u 发帖数: 61 | 8 这个杂志是同行评议的吗?如果是,reviewer为什么会同意发表这样的文章呀? |
h*d 发帖数: 19309 | 9 mayo clinic也研究喇嘛,说是打座(meditation)以后体内stem cell比例增加。
【在 q******g 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 他们可以给白血病病人发功,抽出血样,看看细胞的变化,看看基因表达的变化,蛋白 : 的变化,如果有足够多的病人有好转,说不定能发NEJM.
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c******r 发帖数: 3778 | 10 哪里来的funding?是不是那个institute of alternative medicine干的?
cells.
【在 x**********o 的大作中提到】![](/moin_static193/solenoid/img/up.png) : Cell Physiol Biochem. 2013;31(1):113-22. doi: 10.1159/000343354. Epub 2013 : Jan 25. : External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF- : 312;B and induces cell cycle arrest and apoptosis in colorectal cancer cells. : Yan X, Shen H, Jiang H, Hu D, Wang J, Wu X. : Background/Aims: Colorectal cancer (CRC) is the second leading cause of : cancer death in the Western countries. Novel approaches of treatment are : needed for CRC. The purpose of the present study was to investigate : cytotoxic effect of external Qi of Yan Xin Qigong (YXQ-EQ) on human : colorectal cancer cells. Methods: The effect of YXQ-EQ on viability, cell
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d********0 发帖数: 534 | 11 看清楚是哈佛发的,还有几个挺牛的医学研究院
【在 c******r 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 哪里来的funding?是不是那个institute of alternative medicine干的? : : cells.
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c******r 发帖数: 3778 | 12 看得很清楚
最后的acknowledgements写的,严新基金支持的研究。其他的资金来源一个字都没提。
“Acknowledgements
This work was supported in part by Yan Xin Foundation.”
引用的也全部都是他们自己的文章。
里面100%伪造数据。
好了,还有啥需要看清楚的?
【在 d********0 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 看清楚是哈佛发的,还有几个挺牛的医学研究院
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d**e 发帖数: 2420 | 13 方舟子:
王林“大师”还在玩90年代的杂耍,其前辈严新“大师”在美国已升级为生物学家了,
以第一作者的身份和其在美留学的中国信徒发了几篇研究严新气功的英文论文,还是在
SCI期刊上,最新的一篇是今年2月发的,标题翻译过来叫《严新气功外气阻止结肠直肠
癌细胞中Akt, Erk1/2和NF-?B的激活并诱导细胞周期阻滞和凋亡》http://t.itc.cn/PNM5g 。牛吧?谁想重复实验还得请严新去发功并让他当第一作者。严新的工作单位除了他自己在纽约注册的“新医学科学研究所”,怎么还有一个是重庆中医研究所?他还没被除名?"" |
d**e 发帖数: 2420 | 14 方舟子:“曾有人问严新,既然气功能治百病,为什么他还是近视?严新回答:我这不
是近视,我戴眼镜是不想让眼里的精光吓到人。” |
N******K 发帖数: 10202 | 15 你是作者之一 伪造数据的?
【在 c******r 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 看得很清楚 : 最后的acknowledgements写的,严新基金支持的研究。其他的资金来源一个字都没提。 : “Acknowledgements : This work was supported in part by Yan Xin Foundation.” : 引用的也全部都是他们自己的文章。 : 里面100%伪造数据。 : 好了,还有啥需要看清楚的?
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j*****7 发帖数: 89 | 16 充分说明了一个问题,出来显的大多是大忽悠。
真正牛逼的道家佛家的人物是不会玩这一套小把戏的。 |
l******a 发帖数: 3339 | 17 WTF,这居然不是joke,OMFG!!!
cells.
【在 x**********o 的大作中提到】![](/moin_static193/solenoid/img/up.png) : Cell Physiol Biochem. 2013;31(1):113-22. doi: 10.1159/000343354. Epub 2013 : Jan 25. : External Qi of Yan Xin Qigong inhibits activation of Akt, Erk1/2 and NF- : 312;B and induces cell cycle arrest and apoptosis in colorectal cancer cells. : Yan X, Shen H, Jiang H, Hu D, Wang J, Wu X. : Background/Aims: Colorectal cancer (CRC) is the second leading cause of : cancer death in the Western countries. Novel approaches of treatment are : needed for CRC. The purpose of the present study was to investigate : cytotoxic effect of external Qi of Yan Xin Qigong (YXQ-EQ) on human : colorectal cancer cells. Methods: The effect of YXQ-EQ on viability, cell
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P*A 发帖数: 7996 | 18 这TMD才是真正的劝退贴啊
【在 l******a 的大作中提到】![](/moin_static193/solenoid/img/up.png) : WTF,这居然不是joke,OMFG!!! : : cells.
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g*********9 发帖数: 3528 | 19 reviewer瞎了X眼了。
给杂志社发信,揭露这个气功!
上海气功研究所就挨着精神卫生中心。
【在 c******r 的大作中提到】![](/moin_static193/solenoid/img/up.png) : 看得很清楚 : 最后的acknowledgements写的,严新基金支持的研究。其他的资金来源一个字都没提。 : “Acknowledgements : This work was supported in part by Yan Xin Foundation.” : 引用的也全部都是他们自己的文章。 : 里面100%伪造数据。 : 好了,还有啥需要看清楚的?
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