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发帖数: 1469 | 1 J Infect Dis. 1978 Mar;137(3):221-6.
Experimental infection of Tupaia belangeri (tree shrews) with herpes simplex
virus types 1 and 2.
Darai G, Schwaier A, Komitowski D, Munk K.
Abstract
The susceptibility of Tupaia belangeri (tree shrews, which are primitive
prosimian primates) to infection with herpes simplex virus (HSV) and the
pathogenesis of HSV in these animals were investigated. Juvenile (28--45
days old) and adult (150 days old) animals were inoculated intravenously,
intraperitoneally, or subcutaneously with HSV type 1 or 2 (25--10(5) plaque-
forming units per animal). Clinical illness usually appeared in juvenile
animals on the second day after inoculation, and the animals died between
two and 14 days after inoculation. High titers of infectious HSV were
recovered from liver and spleen. The histopathologic examination always
showed severe liver changes with numerous necrotic areas. The morphologic
events in the liver were designated as herpetic hepatitis. The next most
common morphologic findings were encephalitis and fibrosis in the spleen.
These results demonstrate the high pathogenicity of HSV types 1 and 2 in
juvenile T. belangeri. In contrast, adult animals did not develop acute
clinical disease and survived the HSV infection.
PMID:
204709
[PubMed - indexed for MEDLINE]
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