f******g
发帖数: 1003 | 1 Early life stress in fathers improves behavioural flexibility in their
offspring
Nature Comm.
Traumatic experiences in childhood can alter behavioural responses and
increase the risk for psychopathologies across life, not only in the exposed
individuals but also in their progeny. In some conditions, such experiences
can however be beneficial and facilitate the appraisal of adverse
environments later in life. Here we expose newborn mice to unpredictable
maternal separation combined with unpredictable maternal stress (MSUS) for 2
weeks and assess the impact on behaviour in the offspring when adult. We
show that MSUS in male mice favours goal-directed behaviours and behavioural
flexibility in the adult offspring. This effect is accompanied by
epigenetic changes involving histone post-translational modifications at the
mineralocorticoid receptor (MR) gene and decreased MR
expression in the hippocampus. Mimicking these changes pharmacologically in
vivo reproduces the behavioural phenotype. These findings highlight the
beneficial impact that early adverse experiences can have in adulthood, and
the implication of epigenetic modes of gene regulation. |
m*********D
发帖数: 1727 | |
f******g
发帖数: 1003 | 3 ::__)) hands with ters
【在 m*********D 的大作中提到】
: 嗯，博士后的儿女会得福。LOL.
|
D*a
发帖数: 6830 | |
d********0
发帖数: 534 | |
f******g
发帖数: 1003 | 6 这个结果是不是可以部分解释进化论呢
上代早起经历会通过表观遗传的方式影响下带的行为方式。 |
Z**********g
发帖数: 222 | 7 貌似要幼年受苦，估计得性腺发育成熟之前（便于跨代表观遗传），所以千老们的孙子
辈受益? |
M****l
发帖数: 416 | 8 这么长的英文，不容易
exposed
experiences
2
【在 f******g 的大作中提到】
: Early life stress in fathers improves behavioural flexibility in their
: offspring
: Nature Comm.
: Traumatic experiences in childhood can alter behavioural responses and
: increase the risk for psychopathologies across life, not only in the exposed
: individuals but also in their progeny. In some conditions, such experiences
: can however be beneficial and facilitate the appraisal of adverse
: environments later in life. Here we expose newborn mice to unpredictable
: maternal separation combined with unpredictable maternal stress (MSUS) for 2
: weeks and assess the impact on behaviour in the offspring when adult. We
|
