s********9
发帖数: 132 | 1 Leibiger, I. B. and Berggren, P. O. "Regulation of glucose homeostasis using
radiogenetics and magnetogenetics in mice." Nat Med (2015)Jan. 21(1): 14-16.
they have a science paper before this one. |
m****a
发帖数: 270 | 2
using
16.
你说的这篇文章是针对同期Jeffrey Friedman实验室发表在Nat Med上文章的的评论
Remote regulation of glucose homeostasis in mice using genetically encoded
nanoparticles
http://www.nature.com/nm/journal/v21/n1/full/nm.3730.html
在这篇文章里，Friedman 先提出了adiogenetics 和 magnetogenetics的概念。
而之前发表在2012年Science上的文章也是Friedmen的
http://science.sciencemag.org/content/336/6081/604.full
最近，他们刚刚在Nature上发表了一篇新的文章首次实现了用磁场抑制神经元活动。
http://www.nature.com/nature/journal/v531/n7596/full/nature1718
【在 s********9 的大作中提到】
: Leibiger, I. B. and Berggren, P. O. "Regulation of glucose homeostasis using
: radiogenetics and magnetogenetics in mice." Nat Med (2015)Jan. 21(1): 14-16.
: they have a science paper before this one.
|
s********9
发帖数: 132 | 3 Thanks for clarifying.
I was just trying to say "只要我们有了magnetogenetics这个词。。。。。"is
technically wrong already because this word had been taken before their
discussion in the tape.
【在 m****a 的大作中提到】
:
: using
: 16.
: 你说的这篇文章是针对同期Jeffrey Friedman实验室发表在Nat Med上文章的的评论
: Remote regulation of glucose homeostasis in mice using genetically encoded
: nanoparticles
: http://www.nature.com/nm/journal/v21/n1/full/nm.3730.html
: 在这篇文章里，Friedman 先提出了adiogenetics 和 magnetogenetics的概念。
: 而之前发表在2012年Science上的文章也是Friedmen的
: http://science.sciencemag.org/content/336/6081/604.full
|
s********9
发帖数: 132 | 4 BTW, you are obviously expert on this. For curiosity, how long the Calcium-
mediated stimulation can last? Is the signal peak really sharp?
【在 m****a 的大作中提到】
:
: using
: 16.
: 你说的这篇文章是针对同期Jeffrey Friedman实验室发表在Nat Med上文章的的评论
: Remote regulation of glucose homeostasis in mice using genetically encoded
: nanoparticles
: http://www.nature.com/nm/journal/v21/n1/full/nm.3730.html
: 在这篇文章里，Friedman 先提出了adiogenetics 和 magnetogenetics的概念。
: 而之前发表在2012年Science上的文章也是Friedmen的
: http://science.sciencemag.org/content/336/6081/604.full
|
c**********n
发帖数: 177 | 5 一直好奇，谢灿的蛋白不是一个膜蛋白是怎么regulate神经元uptake钙离子的？而且，
没有Cry，MagR alone是没有磁感应能力的，Cry+MagR复合物又要光照作用下才能结合
，既然要光照，那么谢灿他们的MagR也不能实现真正意义上的non-invasive啊。 |
a*******i
发帖数: 27 | 6 看着这么些人都在吵来吵去，就没有人去好好算算这个所谓MagR活着其他实验室所谓
magnetogenetics符不符合物理所原理，
看看这个加州理工教授的批判：
人家这数学公司推来推去，算出来这些都make no sense，MagR活着所谓ferritin产生
的牛顿力不足以拉动蛋白后者激活离子通道。
http://arxiv.org/abs/1604.01359
Magnetic Magic in Nature
Markus Meister
(Submitted on 5 Apr 2016)
This is a commentary on three recent reports in Nature journals regarding
magnetism in biological systems. The first claims to have identified a
protein complex that acts like a compass needle to guide magnetic
orientation in animals (Qin et al., 2016). Two other articles report
creation of a magnetically-gated ion channel by attaching ferritin to an ion
channel and pulling on the ferritin with a magnetic field (Stanley et al.,
2015; Wheeler et al., 2016). Here I argue that these claims are in conflict
with basic laws of physics taught in college. The discrepancies are large:
from 5 to 10 log units. If the reported phenomena do in fact occur, they
must have causes entirely different from the ones proposed by the authors.
One can conveniently analyze these reports with the same back-of-the-
envelope calculations. |
m****a
发帖数: 270 | 7 要想证明ferritin在磁场中能直接打开离子通道得做一个single-channel recording.
如果不能说明存在其他机制。
【在 a*******i 的大作中提到】
: 看着这么些人都在吵来吵去，就没有人去好好算算这个所谓MagR活着其他实验室所谓
: magnetogenetics符不符合物理所原理，
: 看看这个加州理工教授的批判：
: 人家这数学公司推来推去，算出来这些都make no sense，MagR活着所谓ferritin产生
: 的牛顿力不足以拉动蛋白后者激活离子通道。
: http://arxiv.org/abs/1604.01359
: Magnetic Magic in Nature
: Markus Meister
: (Submitted on 5 Apr 2016)
: This is a commentary on three recent reports in Nature journals regarding
|
m****a
发帖数: 270 | 8 Sorry, I am not an expert. I have not read the paper in details.
【在 s********9 的大作中提到】
: BTW, you are obviously expert on this. For curiosity, how long the Calcium-
: mediated stimulation can last? Is the signal peak really sharp?
|
