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发帖数: 130 | 1 paper thanks!
Nat Immunol. 2002 Dec;3(12):1156-62. Epub 2002 Nov 11.
Indirect activation of naïve CD4+ T cells by dendritic cell-derived
exosomes.
Théry C1, Duban L, Segura E, Véron P, Lantz O, Amigorena S.
Author information
Abstract
Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes,
that bear major histocompatibility complex (MHC) and T cell costimulatory
molecules. Here, we found that injection of antigen- or peptide-bearing
exosomes induced antigen-specific naïve CD4+ T cell activation in vivo.
In vitro, exosomes did not induce antigen-dependent T cell stimulation
unless mature CD8alpha- DCs were also present in the cultures. These mature
DCs could be MHC class II-negative, but had to bear CD80 and CD86. Therefore
, in addition to carrying antigen, exosomes promote the exchange of
functional peptide-MHC complexes between DCs. Such a mechanism may increase
the number of DCs bearing a particular peptide, thus amplifying the
initiation of primary adaptive immune responses.
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