b*******0
发帖数: 125 | 1 NATURE | ARTICLE
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
Yalin Zhang, Min Soo Kim, Baosen Jia, Jingqi Yan, Juan Pablo
Zuniga-Hertz, Cheng Han & Dongsheng Cai
Abstract
It has been proposed that the hypothalamus helps to control ageing, but the
mechanisms responsible remain unclear. Here we develop several mouse models
in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1
are ablated, as we observed that ageing in mice started with a substantial
loss of these hypothalamic cells. Each mouse model consistently displayed
acceleration of ageing-like physiological changes or a shortened lifespan.
Conversely, ageing retardation and lifespan extension were achieved in mid-
aged mice that were locally implanted with healthy hypothalamic stem/
progenitor cells that had been genetically engineered to survive in the
ageing-related hypothalamic inflammatory microenvironment. Mechanistically,
hypothalamic stem/progenitor cells contributed greatly to exosomal microRNAs
(miRNAs) in the cerebrospinal fluid, and these exosomal miRNAs declined
during ageing, whereas central treatment with healthy hypothalamic stem/
progenitor cell-secreted exosomes led to the slowing of ageing. In
conclusion, ageing speed is substantially controlled by hypothalamic stem
cells, partially through the release of exosomal miRNAs.
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23282.html?foxtrotcallback=true | s******y
发帖数: 17729 | 2 这种文章看摘要都是多余的，看个标题就知道tmd骗钱扯蛋
miRNAs
the
models
【在 b*******0 的大作中提到】
: NATURE | ARTICLE
: Hypothalamic stem cells control ageing speed partly through exosomal miRNAs
: Yalin Zhang, Min Soo Kim, Baosen Jia, Jingqi Yan, Juan Pablo
: Zuniga-Hertz, Cheng Han & Dongsheng Cai
: Abstract
: It has been proposed that the hypothalamus helps to control ageing, but the
: mechanisms responsible remain unclear. Here we develop several mouse models
: in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1
: are ablated, as we observed that ageing in mice started with a substantial
: loss of these hypothalamic cells. Each mouse model consistently displayed
| h*****n
发帖数: 121 | | d********m
发帖数: 3662 | 4 Partly用在标题里是个巨大进步，很耿直的告诉大家，重复不出你来咬我啊。 | b******e
发帖数: 244 | 5 据说Dongsheng Cai是一个很好的科幻作家 | D****g
发帖数: 275 | 6 不了解Dongsheng Cai, but “科幻作家”，这个词用得好。
【在 b******e 的大作中提到】
: 据说Dongsheng Cai是一个很好的科幻作家
| S**********e
发帖数: 620 | 7 人混的可威风了
【在 s******y 的大作中提到】
: 这种文章看摘要都是多余的，看个标题就知道tmd骗钱扯蛋
:
: miRNAs
: the
: models
| P****R
发帖数: 22479 | 8 哈哈
【在 D****g 的大作中提到】
: 不了解Dongsheng Cai, but “科幻作家”，这个词用得好。
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