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发帖数: 238 | 1 OAP 旗下 International Journal of Clinical Microbiology，无分非SCI哦，稿件情
况如下：
Title: Transcription regulators MarA, SoxS and Rob and CTX-M beta-lactamase
gene sequences as potential diagnostic biomarker in monitoring and
management of antibiotic treatment
Abstract:
Abstract
Extended Spectrum Beta Lactamases (ESBLs) are resistance enzymes that are
responsible for antibiotic resistance and are produced by the CTX-M beta-
lactamase gene in Gram-negative pathogens, such as antibiotic resistant
Escherichia coli. This study uses a bioinformatic approach in identifying
and understanding gene expression regulation between transcription factors
MarA, SoxS, Rob and blaCTX-M promoter as well as investigating the presence
of a consensus sequence within CTX-M groups to determine possibility of
identifying diagnostic markers. It was found through gene analysis that SoxS
and MarA has a high possibility of regulating several CTX-M genes of
different phylogeny. Therefore there is a possibility in reducing antibiotic
resistant traits or enhance antibiotic treatment efficiency against
antibiotic resistant bacterial pathogens. Furthermore, a consensus sequence
was obtained within CTX-M groups, however the length of the sequence was not
sufficient enough to create an ideal primer to target during polymerase
chain reaction to act as a diagnostic biomarker. Further research needed to
be done to widen the search range surrounding the beta-lactamase gene to
find a consensus sequence relating to the function and expression of
antibiotic resistance. In this study, we have consider the prospect of
possible potential in enhancing antibiotic resistant treatments and
diagnostics as well as measuring its progress and effectiveness in patients.
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