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发帖数: 43 | 1 If your research background is in the field of ApoE and Alzheimer's disease,
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ABSTRACT: We examined interactive effects of APOE4 and diabetes risk on
later myelinating WM regions among healthy elderly at risk for AD. A sample
of 107 healthy elderly (80 APOE4-/27 APOE4+) underwent structural MRI/DTI.
DTI data were prepared using TBSS and a-priori ROIs were extracted from T1-
based WM parcellations. ROIs included later myelinating frontal/temporal/
parietal WM regions and control regions, measured by fractional anisotropy (
FA). There were no APOE group differences on DTI for any ROI. Within the
APOE4 group, we found negative relationships between HAIC/fasting glucose
and APOE4 on FA for all later myelinating WM regions, but not for early/
middle myelinating control regions. Results also showed APOE4/diabetes risk
interactions for WM underlying supramarginal, superior temporal, precuneus,
superior parietal, and superior frontal regions. Results suggest interactive
effects of APOE4 and diabetes risk on later myelinating WM regions, which
supports preclinical detection of AD among this particularly susceptible
subgroup. | c****i
发帖数: 373 | |
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