O*C
发帖数: 649 | 1 From Dovepress: Drug Design, Development and Therapy.
first come, first serve | Y****o
发帖数: 13 | 2 Sent to you. Many thanks! | O*C
发帖数: 649 | 3 好像不太适合你啊。。。。
Abstract在这里，做med chem或者类似的给我pm吧
Beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) on psoriasis
have been reported in rats, mice, humans, but the specific mechanisms
involved have not been well clarified. This study used the fat-1 mouse, a
transgenic model that endogenously convert n-3 PUFAs from n-6 FA to directly
determine if outcomes of psoriasis were correlated with n-3 PUFAs. Wild
type (WT) and fat-1 mice, which were treated daily with Imiquimod (IMQ)
cream or control cream on the shaved right ear and dorsal skin, were fed the
same diet. We score the severity of inflammation of the ear and dorsal skin
based on the clinical Psoriasis Area and Severity Index (PASI), epidermal
hyperplasia was measured by H&E staining. The expression of inflammatory
factors in epidermal were analyzed by immunohistochemistry. We used enzyme-
linked immunosorbent assay and flow cytometry to measure the differences of
content of inflammatory factor in blood serum and which of CD4+T cells in
spleen between IMQ-induced fat-1 mice and WT mice. Fat-1 IMQ-induced mice
exhibited significantly lower level of inflammatory cell like T helper 17
cells (Th17 cells) and higher level regulatory T cells (Treg cells) in
spleen as compared to WT IMQ-induced mice. N-3 fatty acids stimulated Th17
cells produced lower level inflammatory factors like IL-17, IL-22, IL-23 and
stimulated Treg cells produced higher anti-inflammatory like Foxp3. In
conclusion, we offer further insight into the mechanisms involved in
preventing the inflammation in psoriasis-like mice by n-3 PUFAs using a fat-
1 transgenic mouse model.
【在 Y****o 的大作中提到】
: Sent to you. Many thanks!
| l*******e
发帖数: 101 | 4 I think my background is close. sent my info.
Thanks
【在 O*C 的大作中提到】
: From Dovepress: Drug Design, Development and Therapy.
: first come, first serve
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