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发帖数: 68 | 1 现转让一篇英国皇家化学学会的杂志的稿子.
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RSC Advances
TITLE: Molecular Basis of R294K Mutation Effects of H7N9 Neuraminidases with
Drugs and cyclic peptides: An in Silico and Experimental Study
ABSTRACT:
In China, the recent outbreak of the new R294K H7N9 has infected 134 people
and killed 45 people since January 2014. Up to date Prof. Gaoet al. report
that an R294K neuraminidase (Shanghai N9: R294K mutation; Anhui N9: no R294K
mutation) results in multi-drug resistance with extreme oseltamivir
resistance (over 100 000-fold). Herein, we report the findings of molecular
simulations and computational alanine-scanning mutagenesis for the cyclic
peptide I with the neuraminidases of the Shanghai N9 and Anhui N9. A. Our
simulation results theoretically and experimentally suggest that the cyclic
peptide I can inhibit the Shanghai N9 and Anhui N9 influenza A virus
neuraminidase | l******9
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R294K
【在 f******6 的大作中提到】
: 现转让一篇英国皇家化学学会的杂志的稿子.
: 如果有相关的经验,又需要审稿,请把你的名字,单位,非个人的email发到我的邮箱.
: RSC Advances
: TITLE: Molecular Basis of R294K Mutation Effects of H7N9 Neuraminidases with
: Drugs and cyclic peptides: An in Silico and Experimental Study
: ABSTRACT:
: In China, the recent outbreak of the new R294K H7N9 has infected 134 people
: and killed 45 people since January 2014. Up to date Prof. Gaoet al. report
: that an R294K neuraminidase (Shanghai N9: R294K mutation; Anhui N9: no R294K
: mutation) results in multi-drug resistance with extreme oseltamivir
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