h***u
发帖数: 90 | 1 Job description
The Laboratory of Dr. Housheng Hansen He at the Ontario Cancer Institute and
the University of Toronto is focused on elucidating the functional role of
epigenetic regulation in cancer development and progression, with a special
focus on interplay between epigenetic regulators and noncoding RNAs. The lab
is utilizing and developing cutting edge experimental and computational
methods based on next-generation sequencing. One computational and two
experimental postdoctoral-fellows will be recruited to take lead of research
projects. Candidates with strong background in epigenetics, genomics,
molecular biology (especially biochemistry) and bioinformatics are
encouraged to apply.
Qualifications
• Ph.D in cellular/molecular biology/bioinformatics-related studies
• Extensive experience in molecular biology or bioinformatics is
required
• Knowledge of epigenetics, genomics, genetics and cancer biology
would be an asset
• Background in next generation sequencing is a definite asset
• Demonstrated excellent publication record of scientific
achievement
• Excellent verbal and written communication skills
• Strong scientific writing and presentation skill
• Demonstrated record of interdisciplinary collaboration
For consideration, please send a CV, a brief statement of scientific/
research interests, contact information for three references and start date
availability to:
h******[email protected]
Selected publications
1. Sun T, et al. Targeting MED1, HECTD2 and RAB1A by mir-221/222 promotes
the development of androgen independency of prostate cancer cells. Oncogene
. 2013. PMID: 23770851.
2. Cai C, et al. ERG Activation of an Androgen Receptor Regulated
Enhancer in the SOX9 Gene Mediates Tumor Development in TMPRSS2:ERG Fusion
Positive Prostate Cancer. J Clin Invest. 2013. PMID: 23426182.
3. He H, et al. Differential DNase I Hypersensitivity reveals Factor-
dependent Chromatin Dynamics. Genome Research. 2012. PMID: 22508765.
4. Xu K, et al. EZH2 Oncogenic Activity in Castration Resistant Prostate
Cancer is Polycomb-Independent. Science. 2012. PMID: 23239736.
5. Cai C, et al. Androgen receptor gene expression in prostate cancer is
directly suppressed by the androgen receptor through recruitment of lysine-
specific demethylase 1. Cancer Cell. 2011. PMID: 22014572.
6. Meyer CA, et al. BINOCh: Binding Inference from Nucleosome Occupancy
Changes. Bioinformatics. 2011. PMID: 21551136.
7. He H, et al. Nucleosome Dynamics Define Transcriptional Enhancers.
Nature Genetics. 2010. PMID: 20208536.
8. He H, et al. “Mapping the C. elegans noncoding transcriptome with a
whole-genome tiling microarray”. Genome Res. 2007. PMID: 17785534.
9. He H, et al. “Profiling Caenorhabditis elegans non-coding RNA
expression with a combined microarray”. Nucleic Acids Res. 2006. PMID:
16738136. |
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