r*s
发帖数: 2555 | 1 摘要：
Since the SARS outbreak 18 years ago, a large number of severe acute
respiratory
syndrome-related coronaviruses (SARSr-CoV) have been discovered in their
natural
reservoir host, bats1–4。Previous studies indicated that some of those bat
SARSr-CoVs
have the potential to infect humans5–7. Here we report the identification
and
characterization of a novel coronavirus (2019-nCoV) which caused an epidemic
of
acute respiratory syndrome in humans in Wuhan, China. The epidemic, which
started
from 12 December 2019, has caused 2,050 laboratory-confirmed infections with
56
fatal cases by 26 January 2020. Full-length genome sequences were obtained
from five
patients at the early stage of the outbreak. They are almost identical to
each other and
share 79.5% sequence identify to SARS-CoV. Furthermore, it was found that
2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus.
The
pairwise protein sequence analysis of seven conserved non-structural
proteins show
that this virus belongs to the species of SARSr-CoV. The 2019-nCoV virus was
then
isolated from the bronchoalveolar lavage fluid of a critically ill patient,
which can be
neutralized by sera from several patients. Importantly, we have confirmed
that this
novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.
结论部分
The study provides the first detailed report on 2019-nCoV, the likely
etiology agent responsible for ongoing acute respiratory syndrome
epidemic in Wuhan, central China. Viral specific nucleotide positive and
viral protein seroconversion observed in all patients tested provides
evidence of an association between the disease and the presence of this
virus. However, there are still many urgent questions to be answered.
The association between the 2019-nCoV and the disease has not been
proved by animal experiments to full the Koch postulates. We don’t
know the transmission routine of this virus among hosts yet. It seems
the virus is becoming more transmissible between human-to-human.
We should closely monitor if the virus continue evolving to become
more virulent. Owing to shortage of specific treatment and considering
the relatedness between SARS-CoV and 2019-nCoV, some drugs and
pre-clinical vaccine against SARS-CoV probably can be applied to this
virus. Finally, considering the wide spread of SARSr-CoV in their natural
reservoirs, future research should be focused on active surveillance of
these viruses through a broader geographic regions. In the long-term,
broad-spectrum antiviral drugs and vaccine should be prepared for
the future emerging infectious diseases caused by this cluster of virus.
Most importantly, strict regulations against the wildlife domestication
and consuming should be implemented. | r*s
发帖数: 2555 | | r*s
发帖数: 2555 | | H********g
发帖数: 43926 | 4 跟我昨天说的一样
要对中国存在的类SARS病毒早做准备
———
Finally, considering the wide spread of SARSr-CoV in their natural
reservoirs, future research should be focused on active surveillance of
these viruses through a broader geographic regions. In the long-term,
broad-spectrum antiviral drugs and vaccine should be prepared for
the future emerging infectious diseases caused by this cluster of virus.
Most import | H********g
发帖数: 43926 | | r*s
发帖数: 2555 | 6 这次为啥在武汉爆发？国内海鲜市场不说上万也得好几千？
【在 H********g 的大作中提到】
: 跟我昨天说的一样
: 要对中国存在的类SARS病毒早做准备
: ———
: Finally, considering the wide spread of SARSr-CoV in their natural
: reservoirs, future research should be focused on active surveillance of
: these viruses through a broader geographic regions. In the long-term,
: broad-spectrum antiviral drugs and vaccine should be prepared for
: the future emerging infectious diseases caused by this cluster of virus.
: Most import
| r*s
发帖数: 2555 | 7 昨天nature在线发表
【在 H********g 的大作中提到】
: 这个好像就是上周初biorxiv上的论文吧
| H********g
发帖数: 43926 | 8 我觉得就是运气不好 下次可能换个城市
从SARS 2018猪病毒 2019nCoV 以及各种对野生动物的研究结果看 我国野外的动物
里可能存在不少冠状病毒 （不一定就只在蝙蝠里） 人和家畜从它们那里获得感染的
机会一直是存在的 所以我觉得可能这种事情以前一直都有 只是以前监测不出来真正
病因 所以不知道而已
【在 r*s 的大作中提到】
: 这次为啥在武汉爆发？国内海鲜市场不说上万也得好几千？
| H********g
发帖数: 43926 | 9 另外别的病毒的威胁也存在 比如前几天挖出来那个武汉疾控的人 就在武汉的野老鼠
里发现了一种汉滩病毒 命名为黄陂病毒 汉滩病毒导致的传染病是最早在朝鲜战争
的时候出现的 然后在70年代确认病毒
现在看起来 野生的病毒相当多 很多都可以感染人 所以研究这些病毒是很重要的
不然下次人感染上以后 仍旧会一样被动
【在 H********g 的大作中提到】
: 我觉得就是运气不好 下次可能换个城市
: 从SARS 2018猪病毒 2019nCoV 以及各种对野生动物的研究结果看 我国野外的动物
: 里可能存在不少冠状病毒 （不一定就只在蝙蝠里） 人和家畜从它们那里获得感染的
: 机会一直是存在的 所以我觉得可能这种事情以前一直都有 只是以前监测不出来真正
: 病因 所以不知道而已
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