c*******n
发帖数: 1648 | 1 Intresting to me, a layman for biomaterials.
Do you know the molecular mechanism of this adsorption? It sounds mysterious
to me though, because I would treat blood as a colloid-polymer solution.
Man-made materials must repel proteins somehow, then there will be a depletion
zone (~ Rg of protein) statically speaking. If the adsorption happens whatever
it takes, there are sth to do with the dynamics of blood?
全 |
b**s
发帖数: 589 | 2 我也来胡扯两句。蛋白质在合成之后要运输到目标地点，有很多要由importer
和exporter来完成，它们识别蛋白质的目标地点是由其特定氨基酸序列决定的。而且细胞
膜是由lipid, 胆固醇和蛋白质组成的，蛋白质进入细胞膜也是靠translocatorI来识别其
特定氨基酸序列。合成材料缺乏这些功能以及messenger molecule，所以会造成蛋白质不
知道往哪里去，就吸附在壁上。
我喜欢瞎想，错了希望大家指正
mysterious
能 |
a***n
发帖数: 578 | 3 what is lipid?
man-made materials doesn't carry information that identify as own body part -
usually code in DNA. so 凝血体系 judge those are intruders and solidify to
kill those intruders. Am I right?
胞
其
不
不
【在 b**s 的大作中提到】
: 我也来胡扯两句。蛋白质在合成之后要运输到目标地点，有很多要由importer
: 和exporter来完成，它们识别蛋白质的目标地点是由其特定氨基酸序列决定的。而且细胞
: 膜是由lipid, 胆固醇和蛋白质组成的，蛋白质进入细胞膜也是靠translocatorI来识别其
: 特定氨基酸序列。合成材料缺乏这些功能以及messenger molecule，所以会造成蛋白质不
: 知道往哪里去，就吸附在壁上。
: 我喜欢瞎想，错了希望大家指正
:
: mysterious
: 能
|
a***n
发帖数: 578 | 4
thx. it sounds a membrane...
part
will those antibodies go for the man-made biomaterials?
且
识
白 |
c*******n
发帖数: 1648 | 5 hehe, DING!
mysterious
能 |
c*******n
发帖数: 1648 | 6 Forgive my simple mind, I considered things from homopolymer point of view.
You already made excellent points. Proteins are way beyond the homo or block
copolymer level in terms of energetic combinations(of conformations). However,
based on your comments, manupulating surface of man-made materials still can
lead to success unless the signal mechanism proposed by boss is right. The
first thing caught in my mind is to understand how those proteins interact
with vesell surface. Why don't they aggre |
d*****s
发帖数: 33 | 7 有一种方法是涂上刻缓慢释放的药,防止血液凝结吧?
要不弄上一层BIODEGRADABLE的材料,每天溶掉一纳米?
全 |
p*****x
发帖数: 68 | |
