m***n
发帖数: 266 | 1 Nature Biotechnology, Vol 21, 10, Oct 2003, 1171.
Shuguang Zhang
Fabrication of novel biomaterials through molecular self-assembly
我的看法:
1.natural or natural mimic peptide作为building block, instead of conventional
polymer, 看起来是很有前途的发展趋势. 对于Tissue engineering, cell patterning
and etc 尤其如此.
2.不知道有没有人做peptide combinatorial library,这种力气活好啊:-)
欢迎拍砖. | w********h
发帖数: 12367 | 2
conventional
不以为然。
即便crosslinked/assembled peptide胜过polymer,
对我们来说也毫无意义。
我们的基准点就在polymer，
那些工作还是由别人做比较合适。
【在 m***n 的大作中提到】
: Nature Biotechnology, Vol 21, 10, Oct 2003, 1171.
: Shuguang Zhang
: Fabrication of novel biomaterials through molecular self-assembly
: 我的看法:
: 1.natural or natural mimic peptide作为building block, instead of conventional
: polymer, 看起来是很有前途的发展趋势. 对于Tissue engineering, cell patterning
: and etc 尤其如此.
: 2.不知道有没有人做peptide combinatorial library,这种力气活好啊:-)
: 欢迎拍砖.
| w********h
发帖数: 12367 | 3 当然你把多肽当作一种大分子研究也可以接受。
不过多肽在可控性、价格、来源、免疫等角度上应该不如polymer。
patterning
【在 w********h 的大作中提到】
:
: conventional
: 不以为然。
: 即便crosslinked/assembled peptide胜过polymer,
: 对我们来说也毫无意义。
: 我们的基准点就在polymer，
: 那些工作还是由别人做比较合适。
| S*****n
发帖数: 6055 | 4
conventional
我记得Wonderlich前面有文章提到过这方面的文章，记不太清楚了。
【在 m***n 的大作中提到】
: Nature Biotechnology, Vol 21, 10, Oct 2003, 1171.
: Shuguang Zhang
: Fabrication of novel biomaterials through molecular self-assembly
: 我的看法:
: 1.natural or natural mimic peptide作为building block, instead of conventional
: polymer, 看起来是很有前途的发展趋势. 对于Tissue engineering, cell patterning
: and etc 尤其如此.
: 2.不知道有没有人做peptide combinatorial library,这种力气活好啊:-)
: 欢迎拍砖.
| c*s
发帖数: 2145 | 5
conventional
Undoubtly to fully utilize the unique assembly of biomolecules are important
in science and technology in terms of their capability to manipulate tiny
objects.
However, to realize their potential, several drawbacks should be overcome
first. 1. the reproducibility, that is, the materials through this way can not
be parallel produced. 2. the quality, ppl claimed so called "wire" can be
formed through DNA templating, as I understand, a wire is used for conducting
charges. if the w
【在 m***n 的大作中提到】
: Nature Biotechnology, Vol 21, 10, Oct 2003, 1171.
: Shuguang Zhang
: Fabrication of novel biomaterials through molecular self-assembly
: 我的看法:
: 1.natural or natural mimic peptide作为building block, instead of conventional
: polymer, 看起来是很有前途的发展趋势. 对于Tissue engineering, cell patterning
: and etc 尤其如此.
: 2.不知道有没有人做peptide combinatorial library,这种力气活好啊:-)
: 欢迎拍砖.
| c*****e
发帖数: 238 | 6 I think non natural amino acids will and can be added to the library of such
polypeptides. As for control, such method of biosynthesis should be easier to
control compared with chemical synthesis.
Personally I think using biochemical method to synthesize materials is very
promising.
【在 w********h 的大作中提到】
: 当然你把多肽当作一种大分子研究也可以接受。
: 不过多肽在可控性、价格、来源、免疫等角度上应该不如polymer。
:
: patterning
| c*****e
发帖数: 238 | 7 Probably someone could claim that first generate some stuff then find their
applications has advantages, but I always think one should know, at least sort
of, what one can use that thing for, before starting off with any assembly or
nanotubes. There are more such stuff which have not found any applications than
those which are under development. | m***n
发帖数: 266 | 8 恩，看了大家的讨论，有不少收益。
看来大家比较一致认为少点花哨，实用才行。
我个人主要觉得最开始的思路，也就是想到用天然和
模拟的多肽做砖块，以及如何巧妙去用这些砖块，很
有启发性。希望有一天也能有这种火花，呵呵。
sort
or
than
了新
纳米
很多
patterning
【在 c*****e 的大作中提到】
: Probably someone could claim that first generate some stuff then find their
: applications has advantages, but I always think one should know, at least sort
: of, what one can use that thing for, before starting off with any assembly or
: nanotubes. There are more such stuff which have not found any applications than
: those which are under development.
| a***n
发帖数: 578 | 9
use nano stuff as building block is a very old idea.
hehe. you can use anything nano as building block and make sth. then publish a
paper. that is so called watering. that is that famous young fudan master was
doing. check out his papers. hoho.
their
出
了
了
【在 m***n 的大作中提到】
: 恩，看了大家的讨论，有不少收益。
: 看来大家比较一致认为少点花哨，实用才行。
: 我个人主要觉得最开始的思路，也就是想到用天然和
: 模拟的多肽做砖块，以及如何巧妙去用这些砖块，很
: 有启发性。希望有一天也能有这种火花，呵呵。
:
: sort
: or
: than
: 了新
| w********h
发帖数: 12367 | 10 although I myself is trying to get some publiscations on top journals,
I still sniff at those words about "promising" in those conclusions from those
people with little clinical experience.
a
was
least
assembly
applications
西北的Stupp用peptide自组装做了很多nanowire的东东，今年他们用这个作base长
出
做
【在 a***n 的大作中提到】
:
: use nano stuff as building block is a very old idea.
: hehe. you can use anything nano as building block and make sth. then publish a
: paper. that is so called watering. that is that famous young fudan master was
: doing. check out his papers. hoho.
: their
: 出
: 了
: 了
| | | m***n
发帖数: 266 | 11 argon,我知道你是很牛的:-)
不过如果你看看原文,就知道那些人不是为了做出什么很酷的
而做,而是从生物相似性上在研究.
我觉得这点和其他做纳米的有很大区别.纳米生物方面
的确可以从大自然学习很多,而不是闭门造车,只求新奇.
a
was
least
assembly
applications
西北的Stupp用peptide自组装做了很多nanowire的东东，今年他们用这个作base长
出
做
【在 a***n 的大作中提到】
:
: use nano stuff as building block is a very old idea.
: hehe. you can use anything nano as building block and make sth. then publish a
: paper. that is so called watering. that is that famous young fudan master was
: doing. check out his papers. hoho.
: their
: 出
: 了
: 了
| m***n
发帖数: 266 | 12 嗯,同意.不过其中引用的一些人是和医学研究很紧密的.
Langer以前也没有临床经验,不过并不妨碍他的技术推动
了很多抗癌药物的进步.(当然Judah Folkman领他入了门)
我也听过很多医生的seminar,他们其实也很感兴趣新的材料
和技术.
搞临床的和工业届的都注重实际效果,这没问题.不过搞
sciece的是需要有点异想天开.大家也不用轻视.角度不同
而已.Personally I enjoy reading fancy ideas, hehe.
those
publish
装
也
【在 w********h 的大作中提到】
: although I myself is trying to get some publiscations on top journals,
: I still sniff at those words about "promising" in those conclusions from those
: people with little clinical experience.
:
: a
: was
: least
: assembly
: applications
: 西北的Stupp用peptide自组装做了很多nanowire的东东，今年他们用这个作base长
| w********h
发帖数: 12367 | 13 hehe...pat pat...
when I saw some people without any practical knowledge wrote some
possible promising properties in the conclusion part, I just could
not help laughing out...of course, I always do the same thing, and
I always laugh at myself...
in fact that part means:"well, my work is done; as to the rest,
whoever has interests feel free to develope, God bless u, good man"...
master
find
【在 m***n 的大作中提到】
: 嗯,同意.不过其中引用的一些人是和医学研究很紧密的.
: Langer以前也没有临床经验,不过并不妨碍他的技术推动
: 了很多抗癌药物的进步.(当然Judah Folkman领他入了门)
: 我也听过很多医生的seminar,他们其实也很感兴趣新的材料
: 和技术.
: 搞临床的和工业届的都注重实际效果,这没问题.不过搞
: sciece的是需要有点异想天开.大家也不用轻视.角度不同
: 而已.Personally I enjoy reading fancy ideas, hehe.
:
: those
| m***n
发帖数: 266 | 14 This paragraph can be used as concluding remarks when giving an oral
presentation. Americans, and me too, like this kind of humor:-)
at | a***n
发帖数: 578 | 15 no. I am nobdy.
I didn't depreciate their works because I have no idea in their fields. I just
comment there are a lot of waterings around. hoho.
publish
装
也
【在 m***n 的大作中提到】
: argon,我知道你是很牛的:-)
: 不过如果你看看原文,就知道那些人不是为了做出什么很酷的
: 而做,而是从生物相似性上在研究.
: 我觉得这点和其他做纳米的有很大区别.纳米生物方面
: 的确可以从大自然学习很多,而不是闭门造车,只求新奇.
:
: a
: was
: least
: assembly
| c*****e
发帖数: 238 | 16 That is why I prefer to work in an area with well defined problems.
In the conclusion part, you can say something like this:
Our result implies that ... can account for ... which could potentially
solve the problem of ...
For those work towards real applications, things are different.
【在 w********h 的大作中提到】
: hehe...pat pat...
: when I saw some people without any practical knowledge wrote some
: possible promising properties in the conclusion part, I just could
: not help laughing out...of course, I always do the same thing, and
: I always laugh at myself...
: in fact that part means:"well, my work is done; as to the rest,
: whoever has interests feel free to develope, God bless u, good man"...
:
: master
: find
|
|
