w********h
发帖数: 12367 | 1 http://www.umich.edu/~urecord/0405/Jan24_05/05.shtml
Research
Nano 'Tinkertoys' may improve cancer therapy
By Karl Leif Bates
News Service
U-M researchers have developed a faster, more efficient way to produce a wide
variety of nanoparticle drug delivery systems, using DNA molecules to bind the
particles together.
A nanoparticle assembly with folate attached on one end and a fluorescent
protein on the other is held together by complementary strands of DNA. It
selectively targets cancer cells and |
a***n
发帖数: 578 | 2 let us dig its weaknesses.
such dendrimer didn't pass FDA.
it means 5-10 years to get approval.
hehe.
wide
the
star-like
different
to
Biomedical
two
single-stranded,
of
【在 w********h 的大作中提到】
: http://www.umich.edu/~urecord/0405/Jan24_05/05.shtml
: Research
: Nano 'Tinkertoys' may improve cancer therapy
: By Karl Leif Bates
: News Service
: U-M researchers have developed a faster, more efficient way to produce a wide
: variety of nanoparticle drug delivery systems, using DNA molecules to bind the
: particles together.
: A nanoparticle assembly with folate attached on one end and a fluorescent
: protein on the other is held together by complementary strands of DNA. It
|
a***n
发帖数: 578 | 3 second,genic therapth need drug to pentrate cell membrane. obviously, it is
not easy for a dendrimer to go through.
just 1 cent. hehe
cell
using
Ruth
Biologic
are
notoriously
added
【在 a***n 的大作中提到】
: let us dig its weaknesses.
: such dendrimer didn't pass FDA.
: it means 5-10 years to get approval.
: hehe.
:
: wide
: the
: star-like
: different
: to
|
a***n
发帖数: 578 | 4 some advantage may be that ppl are eager to find new method at gene therapy
because bacterium gene therapy was reported as death path. Last year, one
person was killed by such method. The MIT professor seems to fall in a lawsuit
for that event.
bind
fluorescent
It
to
of
【在 a***n 的大作中提到】
: second,genic therapth need drug to pentrate cell membrane. obviously, it is
: not easy for a dendrimer to go through.
: just 1 cent. hehe
:
: cell
: using
: Ruth
: Biologic
: are
: notoriously
|
b**s
发帖数: 589 | 5 It's not better than a fluoresence tagged antibody and Folate receptors is
not unique for tumor cell.
One thing I was confused that Folate receptors are expressed on the cell
surface, how can the nano particles enter the cell?
wide
the
star-like
different
to
Biomedical
two
single-stranded,
of
【在 w********h 的大作中提到】
: http://www.umich.edu/~urecord/0405/Jan24_05/05.shtml
: Research
: Nano 'Tinkertoys' may improve cancer therapy
: By Karl Leif Bates
: News Service
: U-M researchers have developed a faster, more efficient way to produce a wide
: variety of nanoparticle drug delivery systems, using DNA molecules to bind the
: particles together.
: A nanoparticle assembly with folate attached on one end and a fluorescent
: protein on the other is held together by complementary strands of DNA. It
|
c***r
发帖数: 3965 | 6 there were reports that nanoparticles can go readily into living cells...
cell
using
Ruth
Biologic
are
notoriously
added
【在 b**s 的大作中提到】
: It's not better than a fluoresence tagged antibody and Folate receptors is
: not unique for tumor cell.
: One thing I was confused that Folate receptors are expressed on the cell
: surface, how can the nano particles enter the cell?
:
:
: wide
: the
: star-like
: different
|
a***n
发帖数: 578 | 7 It is right. 20-80nm surface hydrophilic NPs can pentrate into living cell.
However, its current method can't guantee the NP will not escape from living
cells at the other side.
Anyway, it is a nice paper. far away from so-called breakthrough though.
is
bind
fluorescent
It
to
of
【在 c***r 的大作中提到】
: there were reports that nanoparticles can go readily into living cells...
:
: cell
: using
: Ruth
: Biologic
: are
: notoriously
: added
|
c***r
发帖数: 3965 | 8 you can make the dedrimers pH sensitive so they can hydrolyze inside cells.
receptors
cell
a
the
bind
molecules—drugs,
【在 a***n 的大作中提到】
: It is right. 20-80nm surface hydrophilic NPs can pentrate into living cell.
: However, its current method can't guantee the NP will not escape from living
: cells at the other side.
: Anyway, it is a nice paper. far away from so-called breakthrough though.
:
: is
: bind
: fluorescent
: It
: to
|
