M*****1
发帖数: 371 | 1 记得step 1说其有致畸作用，但是Ck-kaplan qbank上一道题，就是选用口服
metronidazole治疗怀孕22周妇女的细菌性阴道炎。FDA把它归到categary B了。 |
d**o
发帖数: 618 | 2 methonidazole(甲硝挫)没啥teratogenicity吧，你是不是把它和methotrexate记混了？
【在 M*****1 的大作中提到】
: 记得step 1说其有致畸作用，但是Ck-kaplan qbank上一道题，就是选用口服
: metronidazole治疗怀孕22周妇女的细菌性阴道炎。FDA把它归到categary B了。
|
M*****1
发帖数: 371 | 3 FA step 1 pp190. Antibiotics to avoid in pregnancy: Metronidazole--
mutagenesis.
了？
【在 d**o 的大作中提到】
: methonidazole(甲硝挫)没啥teratogenicity吧，你是不是把它和methotrexate记混了？
|
l*****a
发帖数: 375 | 4 cross the placenta; carcinogenic in rats.
contraindicated during the first trimester. |
l********y
发帖数: 2295 | 5 this is from uptodate:
Pregnancy Implications Teratogenic effects have not been observed in animal
reproduction studies; therefore, the manufacturer classifies metronidazole
as pregnancy category B. Metronidazole crosses the placenta and rapidly
distributes into the fetal circulation. Although there have been a few
reports of facial anomalies after in utero exposure, most studies have not
found an increased risk of congenital abnormalities following maternal use
of metronidazole during the first trimester of pregnancy. In studies that
included women taking metronidazole during all trimesters of pregnancy, an
increased risk of adverse fetal and neonatal outcomes has not been observed.
Because metronidazole has been carcinogenic in some animal species, concern
has been raised whether metronidazole should be used during pregnancy;
however, a strong carcinogenic potential in humans has not been observed,
including one study of prenatal exposure.
Metronidazole pharmacokinetics are similar between pregnant and nonpregnant
patients. Bacterial vaginosis has been associated with adverse pregnancy
outcomes (including preterm labor); metronidazole is recommended for the
treatment of symptomatic bacterial vaginosis in pregnant patients. Vaginal
trichomoniasis has been also associated with adverse pregnancy outcomes (
including preterm labor). Treatment may relieve symptoms and prevent further
sexual transmission; however, metronidazole has not resulted in reduced
perinatal morbidity and should not be used solely to prevent preterm
delivery. Some clinicians consider deferring therapy in asymptomatic women
until >37 weeks gestation. Use of oral metronidazole is contraindicated
during the first trimester (per the FDA approved labeling). Consult current
CDC guidelines for appropriate use in pregnant women. |
M*****1
发帖数: 371 | 6 Make sense. No metronidazole during the first trimester, but can be used to
treat symptomatic BV later. Thanks. |
