So far I understand that we could use thiazides in nephrogenic diabetes
insipidus.
the mechanism is working briefly like following:
Thiazides---->inhibit NaCl in Distal Tubule------>increased Na excretion----
-->ECF contraction---->decrease GFR------------>ultimately increase in Na
and water resorption in Proximal Tubule---->decrease urine output.
My question is "why we cannot treat with furosemide base on the same
mechanism?"
furosemide---->inhibit NaCl in loop of Henle------>increased Na excretion---
--->.etc
looking forward to the replies
thank you in advance
