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发帖数: 233 | 1 中国传统墨汁或可抗癌
健康网站 professorhealth.org 于1月23日报道称，在中国传统文化中，黑色的墨汁可
用来表现极为优美的艺术，例如中国书法和水墨画。科学家也关注墨汁的药用效果，并
尝试探讨其药理机制。
《美国化学会OMEGA刊（ACS Omega）》一篇报告说，墨汁对于癌症向淋巴结的扩散和转
移，具有非侵入性的治疗作用，也就是说墨汁是一种不会给患者造成伤害的有效抗癌药
物。
癌细胞经常会从淋巴管向病灶外转移。对此，西方医学主要使用手术切除方法进行治疗
，但是副作用大，而且无法控制复发。因此，近年来出现非侵入性光热疗法（PTT）来
抗击癌细胞转移。
该方法使用纳米材料来杀死癌细胞，但是这些纳米材料有毒、难以加工生产和价格昂贵。
但是，科学家发现中国墨汁具有类似光热疗法纳米材料的作用，却无毒且价格便宜，有
用于治疗癌症的潜力。
中国墨汁的制备原理是煤烟、松烟与明胶等混合，也就是制成碳元素、水和胶的混合物
。研究者选择胡开文墨（Hu-Kaiwen ink），对此加以分析。胡开文墨汁创于清朝乾隆
年间，距今已有近250年的生产历史。 科学家发现，这种中国传统工艺制作的黑色混合
液体含有纳米颗粒，其中碳原子形成薄层结构。胡开文墨汁在激光下加温后，温度可以
升高至55摄氏度（131华氏度）。
因此，这种墨汁经过光热疗法（PTT）所用的激光照射，能够在实验条件下杀死癌细胞
，而且墨汁颗粒具有探测癌细胞的作用。科学家希望将墨汁用于开发抗癌新疗法。
实际上，中国以墨汁为药的历史超过一千年。据宋朝开国皇帝指定修撰的药典《开宝本
草》记载，好墨可以入药。
按照中医理论，墨的药味“辛、平”，可归入心、肝和肾三个脏器所属的经络，具有止
血、消肿的功效，可用于孕妇产后血晕等疾患。
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Ancient ink for cancer treatment
January 23, 2018 (professorhealth.org/2018/01/ancient-ink-for-cancer-
treatment)
For hundreds of years, Chinese calligraphers have used a plant-based ink to
create beautiful messages and art.
Now, one group reports in ACS Omega that this ink could noninvasively and
effectively treat cancer cells that spread, or metastasize, to lymph nodes.
As cancer cells leave a tumor, they frequently make their way to lymph nodes
, which are part of the immune system. In this case, the main treatment
option is surgery, but this can result in complications.
Photothermal therapy (PTT) is an emerging noninvasive treatment option in
which nanomaterials are injected and accumulate in cancer cells.
A laser heats up the nanomaterials, and this heat kills the cells. Many of
these nanomaterials are expensive, difficult-to-make and toxic.
However, a traditional Chinese ink called Hu-Kaiwen ink (Hu-ink) has similar
properties to the nanomaterials used in PTT.
For example, they are the same color, and are both carbon-based and stable
in water. So Wuli Yang and colleagues wanted to see if Hu-ink could be a
good alternative material for PTT.
The researchers analyzed Hu-ink and found that it consists of nanoparticles
and thin layers of carbon. When Hu-ink was heated with a laser, its
temperature rose by 131 degrees Fahrenheit, much higher than current
nanomaterials.
Under PPT conditions, the Hu-ink killed cancer cells in a laboratory dish,
but under normal conditions, the ink was non-toxic. This was also the
scenario observed in mice with tumors.
The researchers also noted that Hu-ink could act as a probe to locate tumors
and metastases because it absorbs near-infrared light, which goes through
skin. |
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