x**c
发帖数: 1435 | | f****o
发帖数: 2770 | 2 ginko
【在 x**c 的大作中提到】
: rt
| h**********a
发帖数: 562 | 3 ginko能起到预防和治疗作用？能展开说说吗？谢谢
【在 f****o 的大作中提到】
: ginko
| f****o
发帖数: 2770 | 4 POSSIBLY EFFECTIVE
Age-related memory impairment. Taking ginkgo leaf extract orally seems to
improve cognitive function in some elderly people with mild to moderate age-
related memory or cognitive impairment. Ginkgo leaf extract might modestly
improve some measures of cognitive function, particularly short-term visual
memory and possibly speed of cognitive processing, in non-demented patients
with age-related memory impairment (5717,6216). But taking ginkgo leaf
extract does not improve memory in people over the age of 60 with normal
mental function (5718,8586,8587,8588).
Clinical research also shows that taking a standardized ginkgo leaf extract
(Thorne Research) 240 mg daily does not reduce the risk of developing age-
related cognitive impairment in elderly patients aged 85 years and older who
have normal cognitive function (16635).
Ginkgo has also been evaluated for prevention of dementia in patients with
existing age-related cognitive impairment. Epidemiologic research shows that
taking ginkgo is not associated with a decreased risk of developing
dementia in elderly patients with memory impairment; however, it might be
associated with a decreased risk of overall mortality (14812). A large-scale
clinical trial also shows that taking ginkgo extract 120 mg twice daily
does not reduce the risk of developing all-cause dementia or Alzheimer's
disease in elderly patients with mild cognitive impairment (16634).
Cognitive function. Taking ginkgo leaf extract orally seems to improve some
measures of cognitive function in healthy young to middle-aged people.
Ginkgo might modestly improve memory and speed of cognitive processing,
including increasing speed of performance on factors assessing attention in
people with no complaints of memory impairment (6214,6215,8236,8544,8588,
9759). Lower doses of 120-240 mg per day seem to be as effective or more
effective than higher doses up to 600 mg per day (6214,8236,8588). Some
evidence suggests a combination of Panax ginseng and ginkgo is effective for
enhancing memory and that the combination might be more effective than
either product alone (8591,9759).
Dementia. Some evidence shows that taking ginkgo leaf extract orally
modestly improves symptoms of Alzheimer's, vascular, or mixed dementias.
Studies lasting from 3 months to a year show that ginkgo leaf extract can
stabilize or improve some measures of cognitive function and social
functioning in patients with multiple types of dementia (1514,1515,2665,2666
,6222,6223,6224,6225,6490,11981,16636) (17191,17717). However, due to poor
study quality, there are concerns that some of the early ginkgo studies may
not be reliable. Although most clinical trials show benefit, there are some
conflicting findings suggesting inconsistent and unpredictable potential
benefits (5720,16636,16637).
There has been some debate about whether ginkgo is more effective in
dementia patients who have neuropsychiatric symptoms. Clinical research
shows that ginkgo is not more effective in patients with neuropsychiatric
symptoms compared to those without (17717).
Most clinical studies have not compared ginkgo to conventional drugs such as
the cholinesterase inhibitors. However, in a preliminary comparative trial,
a specific ginkgo leaf extract (EGb 761, Tanakan, Ipsen) 160 mg daily seems
to be comparable to donepezil 5 mg daily for mild to moderate Alzheimer's
dementia after 24 weeks of treatment (14499). Indirect comparisons suggest
that ginkgo might be less effective than the conventional drugs donepezil (
Aricept), tacrine (Cognex), and other cholinesterase inhibitors (6224,6490,
11981).
Ginkgo has also been evaluated for prevention of dementia. Epidemiologic
research shows that taking ginkgo is not associated with a decreased risk of
developing dementia in elderly patients with memory impairment; however, it
might be associated with a decreased risk of overall mortality (14812). A
large-scale clinical trial also shows that taking ginkgo extract 120 mg
twice daily does not reduce the risk of developing all-cause dementia or
Alzheimer's disease in elderly patients with normal cognitive function or in
those with mild cognitive impairment (16634).
Most of the clinical studies on the effectiveness of ginkgo leaf for
dementia have used the standardized extracts EGb 761 (Tanakan, Ipsen) and LI
1370 (Lichtwer Pharma). These two extracts are similar and prepared to
contain approximately 24% to 25% flavone glycosides and 6% terpene lactones.
Products with similar ingredients include Ginkai (Lichtwer Pharma), Ginkgo
5 (Pharmline), Ginkgold and Ginkgo (Nature's Way), and Quanterra Mental
Sharpness (Warner-Lambert). |
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