m**c
发帖数: 7349 | 1 He began his prize-winning work in 1988, looking at autophagy in yeast. This
is a well-studied organism, often used by biologists to examine fundamental
cellular processes.
Unfortunately, its cells are small and to start with Dr Ohsumi could not
easily distinguish the autophagosomes within them under a microscope. He
dealt with this difficulty by disabling the manufacture of the lysosomic
digestive enzymes.
That meant autophagosomes were no longer destroyed, and accumulated to the
point where they could be seen and studied—especially if a cell was starved
, in order to encourage autophagy. | m**c
发帖数: 7349 | 2 To eluciate and illuminate the self eating process. |
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