h*****h
发帖数: 264 | 1 我们的第一个科研成果转化是把我们发明的无荧光标记非线性拉曼成像技术[3，8]应用
在脑外科肿瘤切除手术中区分肿瘤边缘[9]。核磁成像可以看到大脑何处有肿瘤，但空
间分辨率不足以看到细胞。脑外科医生手术中需要利用更高分辨率的光学显微镜，传统
的技术是冷冻、切片，用两种染料H&E染色后光学成像，过程繁琐。而我们的快速拉曼
光学成像技术看细胞无需标记，可以大幅度加快手术中肿瘤边缘的鉴别，现在已经被产
品化并试用于脑外科医生们的手术中
核磁成像（左）能看到大脑中的肿瘤，但空间分辨率不足以区分肿瘤边界。传统光学成
像需要复杂的染色，否则不能看到单个细胞（右）：而利用无标记拉曼成像（中）脑外
科医生可以区分肿瘤（蓝，蛋白质分子为主）和正常脑组织（绿，脂肪分子为主）
诺贝尔奖已经多次授予NMR研究者：
NMR Nobel Prize Laureates
A brief historical account of the Nobel Prize Laureates clearly shows the
track of the discovery, development, and applications of NMR spectroscopy.
Otto Stern, USA: Nobel Prize in Physics 1943, "for his contribution to the
development of molecular ray method and his discovery of the magnetic moment
of the proton"
Isidor I. Rabi, USA: Nobel Prize in Physics 1944, "for his resonance method
for recording the magnetic properties of atomic nuclei"
Felix Bloch, USA and Edward M. Purcell, USA: Nobel Prize in Physics 1952, "
for their discovery of new methods for nuclear magnetic precision
measurements and discoveries in connection therewith"
Richard R. Ernst, Switzerland: Nobel Prize in Chemistry 1991, "for his
contributions to the development of the methodology of high resolution
nuclear magnetic resonance (NMR) spectroscopy
Kurt Wüthrich, Switzerland: Nobel Prize in Chemistry 2002, "for his
development of nuclear magnetic resonance spectroscopy for determining the
three-dimensional structure of biological macromolecules in solution"
Paul C. Lauterbur, USA and Peter Mansfield, United Kingdom: Nobel Prize in
Physiology or Medicine 2003, "for their discoveries concerning magnetic
resonance imaging" |
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