l*******2
发帖数: 1 | 1 Cancer Manag Res
. 2019 Jan 4;11:467-474. doi: 10.2147/CMAR.S183299. eCollection 2019.
Mindfulness-based stress reduction in patients with differentiated thyroid
cancer receiving radioactive iodine therapy: a randomized controlled trial
Tianji Liu 1, Wenqi Zhang 1, Shuai Xiao 2, Lei Xu 3, Qiang Wen 1, Lin Bai 1,
Qingjie Ma 1, Bin Ji 1
Affiliations
1Department of Nuclear Medicine, China-Japan Union Hospital of Jilin
University, Changchun, Jilin, China, [email protected]; [email protected]
com.
2Department of Nursing, China-Japan Union Hospital of Jilin University,
Changchun, Jilin, China.
3Department of Psychology and Neurology, China-Japan Union Hospital of Jilin
University, Changchun, Jilin, China.
Abstract
Objective: The aim of this study was to evaluate the efficacy of mindfulness
-based stress reduction (MBSR) on health-related quality of life (QoL),
depression, and anxiety in patients with differentiated thyroid cancer (DTC)
receiving radioactive iodine therapy (RIT).
Patients and methods: A randomized controlled trial of MBSR with 120 DTC
patients was performed. They were randomly assigned into the MBSR
intervention group and usual care (UC) group. An 8-week MBSR program was
administered to the MBSR group starting 8 weeks before RIT. Health-related
QoL, depression, and anxiety were measured immediately before the start of
MBSR (T1), immediately after RIT hospitalization was concluded (1 week after
concluding the last MBSR session, T2), and 3 months after RIT
hospitalization (T3), using the QoL Questionnaire Core 30 Items (QLQ-C30),
Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS).
Results: Fifty-three patients in the UC group and 49 patients in the MBSR
group completed the study and were analyzed. Both the UC and MBSR groups
reported low QoL and high SDS and SAS scores immediately after RIT
hospitalization. Patients randomly assigned to the MBSR group showed
significantly greater improvements in emotional function (P=0.012, d=-0.03
for T2 and d=1.17 for T3), fatigue (P=0.037, d=1.00 for T2 and d=-0.69 for
T3), global QoL (P=0.015, d=1.61 for T2 and d=1.56 for T3), depression (P=0.
027, d=-1.19 for T2 and d=-0.83 for T3), and anxiety (P=0.043, d=-1.00 for
T2 and d=-0.86 for T3).
Conclusion: An 8-week MBSR program significantly improved a wide range of
scales in health-related QoL and mitigated depression and anxiety among DTC
patients receiving RIT.
Keywords: anxiety; depression; differentiated thyroid cancer; mindfulness-
based stress reduction; quality of life; radioactive iodine therapy. |
|
