l*****4
发帖数: 267 | 1 有牛人给讲解一下治疗乳腺癌的药物对大脑功能及行为的影响吗
给几篇review paper也行啊 谢谢了先 | w******y
发帖数: 4871 | 2 breast cancer分型分期，好多不同的化疗药的啊。
【在 l*****4 的大作中提到】
: 有牛人给讲解一下治疗乳腺癌的药物对大脑功能及行为的影响吗
: 给几篇review paper也行啊 谢谢了先
| l*****4
发帖数: 267 | 3 如果可以话给讲一下tamoxifen这种涉及到雌激素受体药对大脑功能和行为的影响
谢谢 | w******y
发帖数: 4871 | 4 I dont know.
but this is the side effect of tamoxifen:
Adverse Reactions Significant
>10%:
Cardiovascular: Vasodilation (41%), flushing (33%), hypertension (11%),
peripheral edema (11%)
Central nervous system: Mood changes (12% to 18%), pain (3% to 16%),
depression (2% to 12%)
Dermatologic: Skin changes (6% to 19%), rash (13%)
Endocrine & metabolic: Hot flashes (3% to 80%), fluid retention (32%),
altered menses (13% to 25%), amenorrhea (16%)
Gastrointestinal: Nausea (5% to 26%), weight loss (23%), vomiting (12%)
Genitourinary: Vaginal discharge (13% to 55%), vaginal bleeding (2% to 23%)
Neuromuscular & skeletal: Weakness (18%), arthritis (14%), arthralgia (11%)
Respiratory: Pharyngitis (14%)
Miscellaneous: Lymphedema (11%)
1% to 10%:
Cardiovascular: Chest pain (5%), venous thrombotic events (5%), edema (4%),
cardiovascular ischemia (3%), angina (2%), deep venous thrombus (≤2%), MI (
1%)
Central nervous system: Insomnia (9%), dizziness (8%), headache (8%),
anxiety (6%), fatigue (4%)
Dermatologic: Alopecia (≤5%)
Endocrine & metabolic: Oligomenorrhea (9%), breast pain (6%), menstrual
disorder (6%), breast neoplasm (5%), hypercholesterolemia (4%)
Gastrointestinal: Abdominal pain (9%), weight gain (9%), constipation (4% to
8%), diarrhea (7%), dyspepsia (6%), throat irritation (oral solution 5%),
abdominal cramps (1%), anorexia (1%)
Genitourinary: Urinary tract infection (10%), leukorrhea (9%), vaginal
hemorrhage (6%), vaginitis (5%), vulvovaginitis (5%), ovarian cyst (3%)
Hematologic: Thrombocytopenia (≤10%), anemia (5%)
Hepatic: AST increased (5%), serum bilirubin increased (2%)
Neuromuscular & skeletal: Back pain (10%), bone pain (6% to 10%),
osteoporosis (7%), fracture (7%), arthrosis (5%), joint disorder (5%),
myalgia (5%), paresthesia (5%), musculoskeletal pain (3%)
Ocular: Cataract (7%)
Renal: Serum creatinine increased (≤2%)
Respiratory: Cough (4% to 9%), dyspnea (8%), bronchitis (5%), sinusitis (5%)
Miscellaneous: Infection/sepsis (≤9%), diaphoresis (6%), flu-like syndrome
(6%), cyst (5%), neoplasm (5%), allergic reaction (3%)
<1 or frequency not defined (limited to important or life-threatening):
Angioedema, bullous pemphigoid, cholestasis, corneal changes, endometrial
cancer, endometrial hyperplasia, endometrial polyps, endometriosis, erythema
multiforme, fatty liver, hepatic necrosis, hepatitis, hypercalcemia,
hyperlipidemia, hypersensitivity reactions, hypertriglyceridemia, impotence
(males), interstitial pneumonitis, loss of libido (males), pancreatitis,
phlebitis, pruritus vulvae, pulmonary embolism, retinal vein thrombosis,
retinopathy, second primary tumors, Stevens-Johnson syndrome, stroke; tumor
pain and local disease flare (including increase in lesion size and erythema
) during treatment of metastatic breast cancer (generally resolves with
continuation); uterine fibroids, vaginal dryness, visual color perception
changes
【在 l*****4 的大作中提到】
: 如果可以话给讲一下tamoxifen这种涉及到雌激素受体药对大脑功能和行为的影响
: 谢谢
| w******y
发帖数: 4871 | 5 Side effects of chemotherapy — Adjuvant chemotherapy is frequently
recommended for both premenopausal and postmenopausal women. (See "Adjuvant
chemotherapy for early stage HER2-negative breast cancer".) The long-term
side effects of chemotherapy for breast cancer include:
•Premature ovarian failure
•Cardiac dysfunction
•Second cancers
•Possible cognitive dysfunction
These are discussed in detail separately. (See "Side effects of adjuvant
chemotherapy for early stage breast cancer".) What follows is a brief
overview of the important aspects of these long-term effects.
【在 l*****4 的大作中提到】
: 有牛人给讲解一下治疗乳腺癌的药物对大脑功能及行为的影响吗
: 给几篇review paper也行啊 谢谢了先
| a**e
发帖数: 5094 | 6 we call it 'Chemo brain". they do cause cognitive dysfunction
【在 l*****4 的大作中提到】
: 有牛人给讲解一下治疗乳腺癌的药物对大脑功能及行为的影响吗
: 给几篇review paper也行啊 谢谢了先
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