b*******r
发帖数: 1073 | |
b*******r
发帖数: 1073 | 2 这个出版日期 : 2004: (没找到全文)
[ 英文调查报告书 ]
Structure-Guided Drug Design Rediscovering the Importance of Drug Structure
for Drug Discovery
中文要点:
基于蛋白质立体结构的药物设计，在特性面及在功效面上应该都算是最稳健的药物开发
法。由于药物的目标复杂化
的缘故，此方法的使用还是有所限制。但是从最近的成功案例来看， 此方法的使用，
的确帮助很多整体性或部分性
医药品的成功研发。
专门针对医药及生化科技领域进行市场调查的美国调查公司 Drug ＆ Market
Development Publications〈总公
司：麻州〉，调查与分析基于蛋白质立体结构的药物设计状况，并有系统地出版综合报
告书 "Structure-Guided
Drug Design: Rediscovering the Importance of Drug Structure for Drug
Discovery "。
此报告书使用包括 140 张图表、23 家企业的分析情报在内的 500 页篇 |
U******m
发帖数: 423 | 3 Currently, structure-based design is not a kind of science but a auxilliary
tool.
If you can design a compound and also synthesize it, you might have more
chances to find a job. |
b*******r
发帖数: 1073 | 4 yes. I'm trying to do this way. I got a MS in organic chem. and now doing Ph
.D. in protein NMR. But I'm worrying that my synthesis is not good as those
focus on synthesis, my structure determination/modeling is not as good as
those focus on structure.
auxilliary
【在 U******m 的大作中提到】
: Currently, structure-based design is not a kind of science but a auxilliary
: tool.
: If you can design a compound and also synthesize it, you might have more
: chances to find a job.
|
i****f
发帖数: 473 | 5 protein nmr is far from drug design ... it's probably about protein folding. for drug design you at least need to know how to use DOCKing
Ph
those
【在 b*******r 的大作中提到】
: yes. I'm trying to do this way. I got a MS in organic chem. and now doing Ph
: .D. in protein NMR. But I'm worrying that my synthesis is not good as those
: focus on synthesis, my structure determination/modeling is not as good as
: those focus on structure.
:
: auxilliary
|
w********g
发帖数: 447 | 6 abbott好像有几个人发过一堆NMR的文章，做ligand screening的
folding. for drug design you at least need to know how to use DOCKing
【在 i****f 的大作中提到】
: protein nmr is far from drug design ... it's probably about protein folding. for drug design you at least need to know how to use DOCKing
:
: Ph
: those
|
z**l
发帖数: 478 | 7 how to search these papers?
thanks a lot
【在 w********g 的大作中提到】
: abbott好像有几个人发过一堆NMR的文章，做ligand screening的
:
: folding. for drug design you at least need to know how to use DOCKing
|
b*******r
发帖数: 1073 | 8 It was patented.
【在 w********g 的大作中提到】
: abbott好像有几个人发过一堆NMR的文章，做ligand screening的
:
: folding. for drug design you at least need to know how to use DOCKing
|
b*******r
发帖数: 1073 | 9 Stephen Fesik SAR by NMR
【在 z**l 的大作中提到】
: how to search these papers?
: thanks a lot
|
U******m
发帖数: 423 | 10 It is hard for a phd major in protein NMR to find a job. It is quite
different with SBDD or LBDD. |
|
|
z**l
发帖数: 478 | 11 would you please talk a little bit more?
【在 U******m 的大作中提到】
: It is hard for a phd major in protein NMR to find a job. It is quite
: different with SBDD or LBDD.
|
w********g
发帖数: 447 | 12 见年前看到过一个C&EN的news
http://pubs.acs.org/cen/coverstory/7923/7923drugdesign.html
【在 z**l 的大作中提到】
: would you please talk a little bit more?
|
z**l
发帖数: 478 | 13 thanks a lot
总觉得protein NMR离application太遥远了。努力的使自己热爱它，不知道将来能否找
到工作。所以有读pharmD的打算。
【在 w********g 的大作中提到】
: 见年前看到过一个C&EN的news
: http://pubs.acs.org/cen/coverstory/7923/7923drugdesign.html
|
U******m
发帖数: 423 | 14
I do not know much info from industry. However, as I know, very few
companies have use protein NMR to screen ligands except Abbott. You can
search Pubmed or just search Google to see whether there are some
publications or positions involve protein NMR.
I know a guy who ever worked in a big pharma company whose major is also
protein NMR. However, the NMR division was cut in order to lower the cost.
【在 z**l 的大作中提到】
: would you please talk a little bit more?
|
z**l
发帖数: 478 | 15 maybe the only chances for protein NMR guys are seeking faculty positions.
I believe it's really powerful but have no idea how it is powerful and what
are the possible applications.
【在 U******m 的大作中提到】
:
: I do not know much info from industry. However, as I know, very few
: companies have use protein NMR to screen ligands except Abbott. You can
: search Pubmed or just search Google to see whether there are some
: publications or positions involve protein NMR.
: I know a guy who ever worked in a big pharma company whose major is also
: protein NMR. However, the NMR division was cut in order to lower the cost.
|
w********g
发帖数: 447 | 16 有三本电子书，不知道对你有用不
http://www.yourbooklib.com/ShowBook.asp?BookId=270
http://www.yourbooklib.com/ShowBook.asp?BookId=144
http://www.yourbooklib.com/ShowBook.asp?BookId=432
都可以下载
what
【在 z**l 的大作中提到】
: maybe the only chances for protein NMR guys are seeking faculty positions.
: I believe it's really powerful but have no idea how it is powerful and what
: are the possible applications.
|
z**l
发帖数: 478 | 17 thanks a lot!
now I'm a little frustrated by the current situation.
My advisor is a 2nd year professor,i'm the first student in this group. so I
can only do NMR expts when he is available. You can imagine...
【在 w********g 的大作中提到】
: 有三本电子书，不知道对你有用不
: http://www.yourbooklib.com/ShowBook.asp?BookId=270
: http://www.yourbooklib.com/ShowBook.asp?BookId=144
: http://www.yourbooklib.com/ShowBook.asp?BookId=432
: 都可以下载
:
: what
|
