u****1
发帖数: 216 | 1 CrCL 的计算是默认用ibw，还是应该先计算bmi，bmi <18.5, actual weight
bmi 正常， 使用ideal body weight, 如果超重， 用 adjusted body weight.
这个在考试中会直接告诉你用什么weight 吗？多谢 | a*****8
发帖数: 2115 | 2 This is actually a controversial now regarding which body weight to use.
But for exam purpose, If actual body weight < ideal body weight, use actual
body weight, otherwise, use ideal body weight.
exam won't tell you which body weight to use. | u****1
发帖数: 216 | | j*******j
发帖数: 84 | 4 Should we use Adjusted body weight for Obese? | l******k
发帖数: 27533 | 5 It depends on the drugs and clinical trials. Some clinical trials used
actually body weight for the obesity.
For underweight patients, I follow what Ann2008 said.
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【在 j*******j 的大作中提到】
: Should we use Adjusted body weight for Obese?
| a*****8
发帖数: 2115 | 6 that's why I said it is controversial now. Originally, IBW is used even for
obese patients, however, studies have found that using IBW significantly
underestimate the creatine clearance where using TBW overestimate the
creatine clearance. alazar-Corcoran Equation is also used in some place that
factor in
height as well. Several study evaluated which equation best correlate with
creatine clearance and it appear that using lean body weight to calculate
eCrCl best correlate actual creatine clearance. However, it is
a bit difficult to calculate lean body weight, and adjusted body weight
appears to be the second best correlate with kidney function.
And also, CrCl is just a number. When making dose adjustment, also factor
the severity of disease, patient's own factors etc.
long story short, I use adjusted body weight to estimate creatine clearance.
【在 j*******j 的大作中提到】
: Should we use Adjusted body weight for Obese?
| j*******j
发帖数: 84 | 7 Thank you for sharing.
PK class in my school drove us nuts :(( | Y**i
发帖数: 24 | 8 I learned from my school is ,if actual body weight(ABW)>120% IBW, use
adjusted body weight which is IBW + 0.4(ABW-IBW), if IBW
IBW in the equation, if ABW |
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