可以，理论上需要有和专业相关的business activity，有没有人查就不知道了。
7.2.2 What types of employment are allowed for students during an OPT STEM
extension? (New or Revised)
Students on a STEM extension can start a business and be self-employed. In
this situation, the student must register his or her business with E-Verify
and work full time. The student must be able to prove that he or she has the
proper business licenses and is actively engaged in a business related to
his or her degree program.
