D**g
发帖数: 739 | 1 case/Control 的CASE group 违反HWE，是不是应该用BAYESIAN estimation 求
HAPLOTYPE的FREQ？ 这种情况下应该怎么样test marker-trait association? 请高手
指点一二，不胜感激 | p*****d
发帖数: 16 | 2 I guess it would be same SAS proc haplotype procedure except you specify EST
= BAYESIAN instead of using default EM algorithm. | D**g
发帖数: 739 | 3 Once you use EST=Bayesian, you can't use trait statement to conduct marker-
trait association test. What should I do? I am going to use haplotype freq
estimated by Bayesian method to creat a new data set, then use logistic
regression or chi-squre test to do the analysis. But I am not sure if it's
correct or not.
If case or control group violated HWE, how should we do association analysis
in general? Any suggestions? Thanks
EST
【在 p*****d 的大作中提到】
: I guess it would be same SAS proc haplotype procedure except you specify EST
: = BAYESIAN instead of using default EM algorithm.
| s*r
发帖数: 2757 | |
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